Search Results - "Scartoni, V."

8-azapurine nucleus: a versatile scaffold for different targets by Giorgi, I, Scartoni, V

“…-Azapurine nucleus is a bioisoster of the purine nucleus. Variously substituted 8-azapurines have been synthesised and studied for their interactions with many…”
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Studies on specific inhibition of benzodiazepine receptor binding by some C-benzoyl-1,2,3-triazole derivatives by Biagi, G, Giorgi, I, Livi, O, Lucacchini, A, Martini, C, Scartoni, V

“…Certain new (1-15) or previously described (16-25) 1,2,3-triazole derivatives, characterized by a C-benzoyl substituent, were synthesized and tested for their…”
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Synthesis of 4,6-disubstituted- and 4,5,6-trisubstituted-2-phenyl-pyrimidines and their affinity towards A1 adenosine receptors by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Lucacchini, A

“…Synthesis and assay of title compounds are reported. The results can support our hypothesis about the possibility that molecules characterized by great…”
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Specific inhibition of binding to benzodiazepine receptors by 1,2,3-triazole derivatives by Biagi, G, Livi, O, Lucacchini, A, Martini, C, Scartoni, V

“…Certain 1,2,3-triazole derivatives were prepared and tested for their ability to displace [3H]diazepam that was bound to bovine brain membrane protein. All the…”
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N(9)-Substituted 2-phenyl-N(6)-benzyl-8-azaadenines: A1 adenosine receptor affinity. A comparison with the corresponding N(6)-substituted 2-phenyl-N(9)-benzyl-8-azaadenines by Biagi, G, Giorgi, I, Livi, O, Scartoni, V

“…The synthesis and the assay of title compounds were accomplished. Biological results indicated the general lack of activity among the tested disubstituted…”
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1,2,3-Triazolo [4,5-d] pyridazines--V. Preparation and adenosine receptor binding of new 4-amino derivatives by Biagi, G, Giorgi, I, Livi, O, Manera, C, Scartoni, V, Lucacchini, A, Senatore, G

“…This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyridazine derivatives which had shown binding affinity towards…”
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New 1,2,3-triazole derivatives (ureas, amides, urethanes) with a potential biological interest by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Martinotti, E, Calderone, V

“…This paper reports the preparation of three series of 1,2,3-triazole derivatives bearing an ureido substituent (compounds 5a-h), a carboxamido substituent…”
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N(6) or N(9) substituted 2-phenyl-8-azaadenines: affinity for A1 adenosine receptors. VII by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Breschi, C, Martini, C, Scatizzi, R

“…The A1 activities shown respectively by N(6) or N(9) substituted 8-azaadenines were compared. At least in some cases, the biological results indicated the…”
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Xanthine oxidase (XO). 4(5)-aminosubstituted-5(4)-carboxyamido-1H-1,2, 3-triazoles: a new class of monocyclic triazole inhibitors by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Tonetti, I, Costantino, L

“…The 4(5)-aminosubstituted-5(4)-carboxyamido-1H-1,2,3-triazoles constitute a new class of monocyclic compounds as effective inhibitors of XO. In the past to…”
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Synthesis of new N(6)-substituted 2-phenyl-8-azaadenosines. Their affinity for adenosine A1 and A2 receptors. A comparison with the corresponding 2-phenyl-9-benzyl-8-azaadenines. VI by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Lucacchini, A, Martini, C, Tacchi, P

“…Comparison of the affinity towards adenosine receptors of 2-phenyl-8-azaadenosines, bearing a lipophilic substituent on N(6), with the corresponding…”
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A method for the synthesis of racemic and optically active 2-substituted 9-(2′,3′-dihydroxypropyl)-8-azahypoxanthines and 8-azaadenines by Barili, P. L., Biagi, G., Giorgi, I., Livi, O., Scartoni, V.

“…Several 9‐(2′,3′‐O‐isopropylidene)‐ and 9‐(2′,3′‐dihydroxypropyl)‐8‐azahypoxanthines and 8‐azaadenines were synthesized by a “one pot” method starting from the…”
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Synthesis and ADA inhibitory activity of new 2-aryl-8-azaadenosines. VIII by Biagi, G, Giorgi, I, Livi, O, Scartoni, V

“…Title compounds were synthesized from the protected beta-D-ribofuranosyl-1-azide, the sodium salt of malononitrile and the suitable aroyl nitrile. The…”
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1,2,3-triazole[4,5-d]pyridazines--IV. Preparation and adenosine receptor binding of new 4 and/or 7 aminoderivatives by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Velo, S, Martini, C, Senatore, G, Barili, P L

“…This paper reports the continuation of the studies on the 4-aminosubstituted 1,2,3-triazole[4,5-d]pyridazine derivatives which had shown binding affinity…”
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2-Aryl-8-azaadenosines: structure-activity relationships in the binding with A1 and A2 receptors. A comparison with the corresponding 9-benzyl-8-azaadenines. III by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Lucacchini, A, Martini, C, Tacchi, P

“…Several title compounds were assayed to determine their relative affinity towards the adenosine receptors. Selectivity ratios (SR) showed a prevalent A1…”
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1,2,3-triazolo[1.5-a]quinazolines: synthesis, benzodiazepine receptor binding and theoretical calculations by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Velo, S, Lucacchini, A, Senatore, G, De Santis, B, Martinelli, A

“…This paper reports the synthesis of 3-substituted-1,2,3-triazolo[1,5-a]quinazolin-5-ones prepared by 1,3-dipolar cycloaddition reaction of 2-azidobenzoic acid…”
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Studies on 1,2,3-triazole derivatives as in vitro inhibitors of prostaglandin synthesis by Biagi, G, Dell'Omodarme, G, Ferretti, M, Giorgi, I, Livi, O, Scartoni, V, Tiscione, E

“…This paper reports some new structural modifications (branching and lengthening of alkanoic substituent, increase of heterocycle-carboxylate distance) on…”
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"One pot" synthesis of 2-substituted 9-(2′-hydroxy-3′-aminopropyl)-8-azahypoxanthines and 8-azaadenines (5-substituted 3-(2′-hydroxy-3′-aminopropyl) 7-amino and 7-hydroxy-3H-1,2,3-triazolo[4,5-d]pyrimidines) by Biagi, G., Franchi, M., Giorgi, I., Livi, O., Scartoni, V.

“…An example of the generalization of the synthesis of 8‐azahypoxanthines A and 8‐azaadenines B, interesting from a medicinal point of view, is presented by…”
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1,2,3-Triazole[4,5-d]pyridazines--I. Analogues of prostaglandin synthesis inhibitors by Biagi, G, Ferretti, M, Giorgi, I, Livi, O, Scartoni, V, Lucacchini, A

“…This paper reports the preparation of new triazolepyridazine derivatives bearing in the 1 position an acidic substituent, on the basis of a working hypothesis…”
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Structure-activity studies on a 1,2,3-triazole derivative, a potent in vitro inhibitor of prostaglandin synthesis: the role of the heterocyclic ring by Biagi, G, Dell'Omodarme, G, Ferretti, M, Giorgi, I, Livi, O, Scartoni, V

“…This paper reports further structural modifications concerning the 1,2,3-triazole ring of the compound A, an effective in vitro inhibitor of prostaglandin…”
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1,2,3-Triazole[4,5-d]pyridazines--II. New derivatives tested on adenosine receptors by Biagi, G, Giorgi, I, Livi, O, Scartoni, V, Martini, C, Tacchi, P, Merlino, S, Pasero, M

“…This paper reports the synthesis and biological evaluation towards A1 and A2 adenosine receptors of new 1,2,3-triazole[4,5-d]pyridazines bearing lipophilic…”
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