Search Results - "Scarpinato, Karin"

The effect of neighboring cells on the stiffness of cancerous and non-cancerous human mammary epithelial cells by Guo, Xinyi, Bonin, Keith, Scarpinato, Karin, Guthold, Martin

“…Using an Atomic Force Microscope (AFM) with a 5.3 m diameter spherical probe, we determined mechanical properties of individual human mammary epithelial cells…”
Get full text

Analysis of single, cisplatin‐induced DNA bends by atomic force microscopy and simulations by Dutta, Samrat, Rivetti, Claudio, Gassman, Natalie R., Young, Carl G., Jones, Bradley T., Scarpinato, Karin, Guthold, Martin

“…Bent DNA, or DNA that is locally more flexible, is a recognition motif for many DNA binding proteins. These DNA conformational properties can thus influence…”
Get full text

Cooperative nuclear localization sequences lend a novel role to the N-terminal region of MSH6 by Gassman, Natalie R, Clodfelter, Jill E, McCauley, Anita K, Bonin, Keith, Salsbury, Jr, Freddie R, Scarpinato, Karin D

“…Human mismatch repair proteins MSH2-MSH6 play an essential role in maintaining genetic stability and preventing disease. While protein functions have been…”
Get full text

Diffusion and Binding of Mismatch Repair Protein, MSH2, in Breast Cancer Cells at Different Stages of Neoplastic Transformation by Sigley, Justin, Jarzen, John, Scarpinato, Karin, Guthold, Martin, Pu, Tracey, Nelli, Daniel, Low, Josiah, Bonin, Keith

“…The interior of cells is a highly complex medium, containing numerous organelles, a matrix of different fibers and a viscous, aqueous fluid of proteins and…”
Get full text

Mismatch Repair Proteins in Recurrent Prostate Cancer by Jarzen, John, Diamanduros, Andrew, Scarpinato, Karin D.

“…Normal cell function requires strict control over the repair of DNA damage, which prevents excessive mutagenesis. An enhanced accumulation of mutations results…”
Get full text

Mismatch Repair Protein Deficiency Compromises Cisplatin-induced Apoptotic Signaling by Topping, Ryan P., Wilkinson, John C., Scarpinato, Karin Drotschmann

“…Mismatch repair (MMR) proteins participate in cytotoxicity induced by certain DNA damage-inducing agents, including cisplatin…”
Get full text

The Elevated Expression of a Mismatch Repair Protein Is a Predictor for Biochemical Recurrence After Radical Prostatectomy by MORRIS, Alixanna M, GENTRY, Michael, PEEHL, Donna M, D'AGOSTINO, Ralph, SCARPINATO, Karin D

“…Purpose: The inability to predict clinical outcome of prostate cancer is a major impediment to effective treatment decisions and patient counseling. New…”
Get full text

Small molecule induction of MSH2-dependent cell death suggests a vital role of mismatch repair proteins in cell death by Vasilyeva, Aksana, Clodfelter, Jill E., Rector, Brian, Hollis, Thomas, Scarpinato, Karin D., Salsbury, Freddie R.

“…Avoidance of apoptosis is one of the hallmarks of cancer development and progression. Chemotherapeutic agents aim to initiate an apoptotic response, but often…”
Get full text

Elevated levels of the mismatch repair protein PMS2 are associated with prostate cancer by Norris, Alixanna M., Woodruff, R.D., D'Agostino Jr, Ralph B., Clodfelter, Jill E., Scarpinato, Karin Drotschmann

“…Background Defects in mismatch repair (MMR) proteins have been identified in various types of cancer. However, an association with prostate cancer has been…”
Get full text

Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response by Clodfelter, Jill E., Gerardi, Anthony R., Vasilyeva, Aksana, Scarpinato, Karin D., Salsbury, Freddie, King, S. Bruce, Gorczynski, Michael J.

“…Mismatch repair proteins modulate the cytotoxicity of several chemotherapeutic agents. We have recently proposed a “death conformation” of the MutS homologous…”
Get full text

Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6 by Holmes, Shannon F., Scarpinato, Karin Drotschmann, McCulloch, Scott D., Schaaper, Roel M., Kunkel, Thomas A.

“…The major eukaryotic mismatch repair (MMR) pathway requires Msh2–Msh6, which, like Escherichia coli MutS, binds to and participates in repair of the two most…”
Get full text

Diffusive Behavior of Mismatch Repair Protein MSH2 in Cells at Different Stages of Cancer by Bonin, Keith D., Sigley, Justin, Jarzen, John, Scarpinato, Karin, Guthold, Martin, Pu, Tracey, Nelli, Daniel, Low, Josiah

Get full text

Conformational Selectivity:Targeting the “death” Conformation of Mutsalpha by Salsbury, Freddie R., Scarpinato, Karin, Vasilyeva, Aksana

Get full text

Mismatch Repair Protein Mobility in Human Cancer Cells by Bonin, Keith D., Sigley, Justin, Guthold, Martin, Scarpinato, Karin, Jarzen, John

Get full text

Mismatch Repair Protein Deficiency Compromises Cisplatin-induced Apoptotic SignalingS by Topping, Ryan P., Wilkinson, John C., Scarpinato, Karin Drotschmann

“…Mismatch repair (MMR) proteins participate in cytotoxicity induced by certain DNA damage-inducing agents, including cisplatin ( cis…”
Get full text

Changes in the Mechanical Properties of Cells undergoing Neoplastic Transformation by Bonin, Keith D., Guthold, Martin, Macosko, Jed, Holzwarth, George, McCauley, Anita, Scarpinato, Karin, Guo, Xinyi, Sigley, Justin, Smelser, Amanda, Jarzen, John

Get full text

The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response by Salsbury, Freddie R., Clodfelter, Jill E., Gentry, Michael B., Hollis, Thomas, Scarpinato, Karin Drotschmann

“…We determined the molecular mechanism of cell death response by MutS homologs in distinction to the repair event. Key protein–DNA contacts differ in the…”
Get full text

Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas by Vageli, Dimitra, Daniil, Zoe, Dahabreh, Jubrail, Karagianni, Eleni, Vamvakopoulou, Dimitra N, Ioannou, Maria G, Scarpinato, Karin, Vamvakopoulos, Nikos C, Gourgoulianis, Konstantinos I, Koukoulis, George K

“…Abstract Background Defects in the human DNA mismatch repair genes (MMR) hMSH2 and hMLH1 are responsible for the development of sporadic and hereditary…”
Get full text

Corrigendum to “Phenotypic mismatch repair hMSH2 and hMLH1 gene expression profiles in primary non-small cell lung carcinomas” [Lung Cancer 64 (2009) 282–288] by Vageli, Dimitra, Daniil, Zoe, Dahabreh, Jubrail, Karagianni, Eleni, Vamvakopoulou, Dimitra N, Ioannou, Maria G, Scarpinato, Karin, Vamvakopoulos, Nikos C, Gourgoulianis, Konstantinos I, Koukoulis, George K

Get full text

Understanding and Predicting Faculty Success in Winning Grant Awards by Delgado, Jose, Zhu, Xingquan, Scarpinato, Karin, Hallstrom, Jason O., Hill, Terje

“…This research involves analytics to address two important questions: (1) Can machine learning help to predict the success of faculty seeking external awards?…”
Get full text