Search Results - "Scarpace, P.J"

Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats by Matheny, M., Shapiro, A., Tümer, N., Scarpace, P.J.

“…Diet-induced obesity (DIO) results in region-specific cellular leptin resistance in the arcuate nucleus (ARC) of the hypothalamus in one strain of mice and in…”
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Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction by Côté, I, Sakarya, Y, Kirichenko, N, Morgan, D, Carter, C S, Tümer, N, Scarpace, P J

“…Melanotan II (MTII) is a potent appetite suppressor that rapidly reduces body mass. Given the rapid loss of anorexic response upon chronic MTII treatment, most…”
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Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity by Zhang, Y, Rodrigues, E, Gao, Y.X, King, M, Cheng, K.Y, Erdös, B, Tümer, N, Carter, C, Scarpace, P.J

“…Abstract Short-term pharmacological melanocortin activation deters diet-induced obesity (DIO) effectively in rodents. However, whether central…”
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Simultaneous introduction of a novel high fat diet and wheel running induces anorexia by Scarpace, E.T, Matheny, M, Strehler, K.Y.E, Shapiro, A, Cheng, K.Y, Tümer, N, Scarpace, P.J

“…Abstract Voluntary wheel running (WR) is a form of physical activity in rodents that influences ingestive behavior. The present report describes an anorexic…”
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Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats by Li, G, Klein, R.L, Matheny, M, King, M.A, Meyer, E.M, Scarpace, P.J

“…Interleukin-6 (IL-6) is a multifunctional cytokine that may have a role in energy regulation. Using a recombinant adeno-associated viral vector expressing…”
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Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area by Scarpace, P.J, Matheny, M, Zhang, Y

“…Abstract Voluntary wheel running (WR) is a form of physical activity in rodents that influences ingestive behavior. This study examined the effects of WR on…”
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Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study by Dhillon, H, Kalra, S.P, Prima, V, Zolotukhin, S, Scarpace, P.J, Moldawer, L.L, Muzyczka, N, Kalra, P.S

“…The weight-reducing effects of leptin are predominantly mediated through the hypothalamus in the brain. Gene therapy strategies designed for weight control…”
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PP.19.20: HIGH FAT PLUS DIETARY FRUCTOSE IS NOT MORE DELETERIOUS THAN A HIGH FAT DIET ON CARDIOVASCULAR HEALTH by Tumer, N., Toklu, H.Z., Muller-Delp, J., Sakarya, Y., Oktay, S., Matheny, M., Kirichenko, N., Carter, C., Morgan, D., Scarpace, P.J.

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Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats by Shklyaev, S, Aslanidi, G, Tennant, M, Prima, V, Kohlbrenner, E, Kroutov, V, Campbell-Thompson, M, Crawford, J, Shek, E.W, Scarpace, P.J

“…Adiponectin (Acrp30) is a physiologically active polypeptide hormone secreted by adipose tissue that shows insulin-sensitizing, antiinflammatory, and…”
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Fructose-induced leptin resistance involves impaired AMPK but intact STAT3 signaling by Shapiro, A., Strehler, K., Ryder, D., Tumer, N., Scarpace, P.J.

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Leptin overexpression in VTA trans-activates the hypothalamus whereas prolonged leptin action in either region cross-desensitizes by Scarpace, P.J., Matheny, M., Kirichenko, N., Gao, Y.X., Tümer, N., Zhang, Y.

“…High-fat feeding or CNS leptin overexpression in chow-fed rats results in a region-specific cellular leptin resistance in medial basal hypothalamic regions and…”
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EXACERBATED AGE-RELATED OBESITY IS TEMPERED BY RENIN ANGIOTENSIN SYSTEM by Bruce, E., Carter, C.S., Sakarya, Y., Toklu, H.Z., Morgan, D., Scarpace, P.J., Tumer, N.

“…Diet-induced obesity is exacerbated in senescent compared with young rats in terms of both high-fat (HF) induced weight gain and increased food consumption…”
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Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats by Scarpace, P.J, Matheny, M, Tümer, N

“…Leptin contributes to the regulation of both food intake and energy expenditure. We previously demonstrated that the F344×BN rat, a rodent model for late-onset…”
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High dietary fructose does not exacerbate the detrimental consequences of high fat diet on basilar artery function by Toklu, H Z, Muller-Delp, J, Sakaraya, Y, Oktay, S, Kirichenko, N, Matheny, M, Carter, C S, Morgan, D, Strehler, K Y E, Tumer, N, Scarpace, P J

“…The objective of the study was to determine the effects of a high fat (HF) diet alone or with high fructose (HF/F) on functional and structural changes in the…”
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Pro-opiomelanocortin Gene Transfer to the NTS but not ARC Ameliorates Chronic Diet-Induced Obesity by Zhang, Y., Rodrigues, E., Gao, Y.X., King, M., Cheng, K.Y., Erdös, B., Tümer, N., Carter, C., Scarpace, P.J.

“…Short-term pharmacological melanocortin activation deters diet-induced obesity (DIO) effectively in rodents. However, whether central pro-opiomelanocortin…”
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Leptin increases uncoupling protein expression and energy expenditure by Scarpace, P J, Matheny, M, Pollock, B H, Tümer, N

“…In ob/ob mice, leptin increases energy expenditure and sympathetic outflow to brown adipose tissue (BAT). To test whether the mechanism of increased energy…”
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Modulation of receptors and adenylate cyclase activity during sucrose feeding, food deprivation, and cold exposure by Scarpace, P.J, Baresi, L.A, Morley, J.E

“…Thermogenesis in brown adipose tissue (BAT) serves as a regulator of body temperature and weight maintenance. Thermogenesis can be stimulated by catecholamine…”
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Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats by Scarpace, P.J., Matheny, M., Zhang, Y., Tümer, N., Frase, C.D., Shek, E.W., Hong, B., Prima, V., Zolotukhin, S.

“…The purpose of this study was to determine if long-term leptin treatment desensitizes leptin signal transduction and the subsequent downstream anorexic and…”
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Dietary vitamin A supplementation in rats: suppression of leptin and induction of UCP1 mRNA by Kumar, M.V, Sunvold, G.D, Scarpace, P.J

“…All-trans-retinoic acid (RA), an active metabolite of vitamin A, induces the gene expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) and…”
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Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression by Li, H. (Department of Veterans Affairs Medical Center, Gainesville, FL.), Matheny, M, Tumer, N, Scarpace, P.J

“…To investigate the role of aging on the fasting-induced suppression of leptin gene expression and increase in hypothalamic neuropeptide Y (NPY) gene…”
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