Detection of clustered circulating tumour cells in early breast cancer

Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or not they manifest in early breast cancer, as their occurrence in patients with metastasis-free primary d...

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Bibliographic Details
Published in:	British journal of cancer Vol. 125; no. 1; pp. 23 - 27
Main Authors:	Krol, Ilona, Schwab, Fabienne D., Carbone, Roberta, Ritter, Mathilde, Picocci, Sabrina, De Marni, Marzia L., Stepien, Grazyna, Franchi, Gian M., Zanardi, Andrea, Rissoglio, Marco D., Covelli, Alfredo, Guidi, Guido, Scarinci, Daniele, Castro-Giner, Francesc, Mazzarella, Luca, Doglioni, Claudio, Borghi, Francesca, Milani, Paolo, Kurzeder, Christian, Weber, Walter P., Aceto, Nicola
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 06-07-2021 Nature Publishing Group
Subjects:	631/67/1347 631/67/2322 Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - pathology Breast Neoplasms - surgery Brief Communication Cancer Research Case-Control Studies Cell Line, Tumor Drug Resistance Epidemiology Female Humans Metastases Metastasis Molecular Medicine Nanostructures Neoplasm Metastasis Neoplasm Staging Neoplastic Cells, Circulating - pathology Oncology Titanium - chemistry Titanium oxide Tumors
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Summary:	Circulating tumour cell (CTC) clusters have been proposed to be major players in the metastatic spread of breast cancer, particularly during advanced disease stages. Yet, it is unclear whether or not they manifest in early breast cancer, as their occurrence in patients with metastasis-free primary disease has not been thoroughly evaluated. In this study, exploiting nanostructured titanium oxide-coated slides for shear-free CTC identification, we detect clustered CTCs in the curative setting of multiple patients with early breast cancer prior to surgical treatment, highlighting their presence already at early disease stages. These results spotlight an important aspect of metastasis biology and the possibility to intervene with anti-cluster therapeutics already during the early manifestation of breast cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-0920 1532-1827
DOI:	10.1038/s41416-021-01327-8