Search Results - "Scardina, JM"

Formation of β -amyloid protein deposits in brains of transgenic mice by Quon, D, Wang, Y, Catalano, R, Scardina, J. Marian, Murakami, K, Cordell, B

“…Deposits of beta-amyloid are one of the main pathological characteristics of Alzheimer's disease. The beta-amyloid peptide constituent (relative molecular mass…”
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Mapping Protein-Protein Interactions by Affinity-Directed Mass Spectrometry by Zhao, Yingming, Muir, Tom W., Stephen B. H. Kent, Tischer, Ed, Scardina, Jan Marian, Chait, Brian T.

“…A precise and rapid method for identifying sites of interaction between proteins was demonstrated; the basis of the method is direct mass spectrometric readout…”
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A Combinatorial Approach to the Identification of Dipeptide Aldehyde Inhibitors of β-Amyloid Production by Higaki, Jeffrey N, Chakravarty, Sarvajit, Bryant, Carmen M, Cowart, Lisa R, Harden, Paul, Scardina, Jan Marian, Mavunkel, Babu, Luedtke, Gregory R, Cordell, Barbara

“…In an effort to rapidly identify potent inhibitors of Aβ production and to probe the amino acid sequence specificity of the protease(s) responsible for the…”
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Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease by Perry, G, Siedlak, SL, Richey, P, Kawai, M, Cras, P, Kalaria, RN, Galloway, PG, Scardina, JM, Cordell, B, Greenberg, BD

“…The major intracytoplasmic lesion of Alzheimer's disease is the neurofibrillary tangle (NFT), which is primarily composed of paired helical filaments (PHFs)…”
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Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders by Murphy, GM, Jr, Forno, LS, Higgins, L, Scardina, JM, Eng, LF, Cordell, B

“…The beta-amyloid peptide (beta AP) has been characterized by protein sequencing techniques as a 39-43 amino acid protein with heterogeneous COOH-termini…”
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