Radiation therapy for minor salivary gland carcinoma

Radiation therapy for minor salivary gland carcinoma

Objectives/Hypothesis: To analyze the outcomes of patients treated for minor salivary gland carcinoma with radiotherapy (RT), either alone or combined with surgery. Study Design: Retrospective review. Methods: Between September 1966 and December 2006, 140 patients were treated with curative intent a...

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Published in:The Laryngoscope Vol. 119; no. 7; pp. 1334 - 1338
Main Authors: Cianchetti, Marco, Sandow, Pamela S., Scarborough, Lauren D., Morris, Christopher G., Kirwan, Jessica, Werning, John W., Mendenhall, William M.
Format: Journal Article
Language:English
Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-07-2009
Wiley-Blackwell
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Combined Modality Therapy
Female
Humans
Male
Medical sciences
Middle Aged
Minor salivary gland carcinoma
Neoplasm Staging
Otorhinolaryngology. Stomatology
radiotherapy
Retrospective Studies
Salivary Gland Neoplasms - pathology
Salivary Gland Neoplasms - radiotherapy
Salivary Gland Neoplasms - surgery
surgery
Survival Rate
Treatment Outcome
Minor salivary gland carcinoma
Carcinoma
Treatment
Surgery
ENT
Malignant tumor
Radiotherapy
Minor salivary gland
Cancer
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Summary:Objectives/Hypothesis: To analyze the outcomes of patients treated for minor salivary gland carcinoma with radiotherapy (RT), either alone or combined with surgery. Study Design: Retrospective review. Methods: Between September 1966 and December 2006, 140 patients were treated with curative intent at our institution for previously untreated minor salivary gland carcinomas (RT alone, 64 patients; combined RT and surgery, 76 patients). Median follow‐up for all patients was 5.5 years. Results: The 10‐year local control rate was 66%, and multivariate analysis revealed that treatment group (P = .0004) and T stage (P = .0001) significantly influenced this endpoint. Patients treated with RT alone had a lower local control rate than patients treated with RT and surgery. The 10‐year local‐regional control rate was 61%, and multivariate analysis revealed that treatment group (P = .0174), overall stage (P = .0004), and N stage (P = .0492) significantly influenced this endpoint. The 10‐year distant metastasis‐free survival rate was 67%, and multivariate analysis revealed that overall stage (P = .0016) significantly influenced this endpoint. The 10‐year cause‐specific survival rate was 56%, and multivariate analysis revealed that overall stage (P < .0001) significantly influenced this endpoint. The 10‐year overall survival rate was 45%, and multivariate analysis revealed that overall stage (P = .0047), N stage (P = .0173), and nerve invasion (P = .0409) significantly influenced this endpoint. Conclusions: Most patients with minor salivary gland carcinoma were cured with RT alone or combined with surgery. Treatment group, T stage, and overall stage significantly influenced the probability of cure. Patients treated with combined surgery and RT had a better prognosis, perhaps due in part to selection bias. Laryngoscope, 2009
Bibliography:The authors have no conflicts of interest to disclose.
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SourceType-Scholarly Journals-1
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content type line 23
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.20501