Search Results - "Scannon, Patrick J."

Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS-Binding Protein in Patients with Severe Sepsis and Septic Shock by Opal, Steven M., Scannon, Patrick J., Vincent, Jean-Louis, White, Mark, Carroll, Stephen F., Palardy, John E., Parejo, Nicolas A., Pribble, John P., Lemke, Jon H.

“…Plasma endotoxin and lipopolysaccharide-binding protein (LBP) levels were measured in a group of 253 patients at the onset of severe sepsis and/or septic…”
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Pilot experience with opebacan/rBPI21 in myeloablative hematopoietic cell transplantation by Guinan, Eva, Avigan, David E, Soiffer, Robert J, Bunin, Nancy J, Brennan, Lisa L, Bergelson, Ilana, Brightman, Spencer, Ozonoff, Al, Scannon, Patrick J, Levy, Ofer

“…Bacterial infection and inflammation contribute significantly to the morbidity and mortality of myeloablative allogeneic hematopoietic cell transplantation…”
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Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders by Issafras, Hassan, Bedinger, Daniel H., Corbin, John A., Goldfine, Ira D., Bhaskar, Vinay, White, Mark L., Rubin, Paul, Scannon, Patrick J.

“…Many therapeutic monoclonal antibodies act as antagonists to receptors by targeting and blocking the natural ligand binding site (orthosteric site). In…”
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Project Recover: Extending the Applications of Unmanned Platforms and Autonomy to Support Underwater MIA Searches by Terrill, Eric J., Moline, Mark A., Scannon, Patrick J., Gallimore, Eric, Shramek, Travis, Nager, Andy, Hess, Robert, Cimino, Megan, Colin, Patrick L., Pietruszka, Andrew, Anderson, Mark R.

“…An estimated 70,000 US servicemen remain missing from World War II, with approximately two-thirds of those losses from the Pacific Theater. Many of the missing…”
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Recombinant bactericidal/permeability-increasing protein (rBPI 21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial by Levin, Michael, Quint, Peter A, Goldstein, Brahm, Barton, Phil, Bradley, John S, Shemie, SD, Yeh, Timothy, Kim, Sun Sook, Cafaro, Daniel P, Scannon, Patrick J, Giroir, Brett P

“…Endotoxin is a primary trigger of the inflammatory processes that lead to shock, multiorgan failure, and purpura fulminans in meningococcal sepsis…”
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E5 Murine Monoclonal Antiendotoxin Antibody in Gram-Negative Sepsis: A Randomized Controlled Trial by Angus, Derek C, Birmingham, Mary C, Balk, Robert A, Scannon, Patrick J, Collins, David, Kruse, James A, Graham, Donald R, Dedhia, Harakh V, Homann, Scott, MacIntyre, Neil, for the E5 Study Investigators

“…CONTEXT Knowledge and understanding of gram-negative sepsis have grown over the past 20 years, but the ability to treat severe sepsis successfully has not…”
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Bactericidal/permeability-increasing protein—Lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia by Giroir, Brett P, Scannon, Patrick J, Levin, Michael

“…OBJECTIVESTo review the scientific rationale for the clinical use of recombinant bactericidal permeability-increasing protein (rBPI21) and to discuss the…”
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Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis by Giroir, B P, Quint, P A, Barton, P, Kirsch, E A, Kitchen, L, Goldstein, B, Nelson, B J, Wedel, N J, Carroll, S F, Scannon, P J

“…Meningococcal sepsis remains an important cause of morbidity and mortality. We hypothesised that children with severe meningococcaemia might benefit from…”
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Preoperative and postoperative endotoxemia in children with congenital heart disease by Lequier, L L, Nikaidoh, H, Leonard, S R, Bokovoy, J L, White, M L, Scannon, P J, Giroir, B P

“…Recent data indicate that increases in inflammatory cytokines are seen in patients with diverse cardiac diseases. However, the primary stimulus for cytokine…”
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Therapy of patients with malignant melanoma using a monoclonal antimelanoma antibody-ricin A chain immunotoxin by SPITLER, L. E, DEL RIO, M, KAWAHATA, R. T, STOUDEMIRE, J. B, FRADKIN, L. B, BAUTISTA, E. E, SCANNON, P. J, KHENTIGAN, A, WEDEL, N. I, BROPHY, N. A, MILLER, L. L, HARKONEN, W. S, ROSENDORF, L. L, LEE, H. M, MISCHAK, R. P

“…We conducted a trial of a murine monoclonal antimelanoma antibody-ricin A chain immunotoxin (XOMAZYME-MEL) in 22 patients with metastatic malignant melanoma…”
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Treatment of Steroid-Resistant Acute Graft-vs-host Disease by In Vivo Administration of an Anti—T-Cell Ricin A Chain Immunotoxin by Kernan, Nancy A, Byers, Vera, Scannon, Patrick J, Mischak, Ronald P, Brochstein, Joel, Flomenberg, Neal, Dupont, Bo, O'Reilly, Richard J

“…The A chain of the toxin ricin has been conjugated by a disulfide bond to a murine monoclonal antibody that recognizes the CD5 (T,p67) antigen present on 95%…”
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Molecular modifications of hemoglobin by Scannon, P J

“…There are two major limitations on the use of acellular hemoglobin solutions in vivo: rapid renal clearance and increased oxygen affinity. A series of chemical…”
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Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation [version 1; peer review: 2 approved] by Guinan, Eva, Avigan, David E, Soiffer, Robert J, Bunin, Nancy J, Brennan, Lisa L, Bergelson, Ilana, Brightman, Spencer, Ozonoff, Al, Scannon, Patrick J, Levy, Ofer

“…Bacterial infection and inflammation contribute significantly to the morbidity and mortality of myeloablative allogeneic hematopoietic cell transplantation…”
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A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis by Greenman, Richard L, Schein, Roland M. H, Martin, Michael A, Wenzel, Richard P, Maclntyre, Neil R, Emmanuel, George, Chmel, Herman, Kohler, Richard B, McCarthy, Mary, Plouffe, Joseph, Russell, Jane A, Hollender, Elena, Immerman, Richard, Pfaller, Michael, Sheetz, Carol, Jebson, Peter, Houston, Alison, Rehak, Dawn, Empson, Patricia, Ireland, Jill, Narain, Shakti, Rashkin, Jack E, Jacobs, Richard A, Octavio, Jacqueline, Coleman, Rebecca, Kenyon, Vicki S, Yangco, Bienvenido G, Toney, John F, Edwards, John, Crislip, Mark, Quenzer, Ronald W, Trenholme, Gordon M, Schmitt, Barbara A, Grossman, Jeffrey E, Daley, Charles L, Chambers, Henry F, Iannini, Paul B, Graziano, Thomas, Dandurand, Ronald, Schieiter, Gary, Kunkel, Mark, Pankey, George A, Mayeur, Brenda, Abadie-Kemmerly, Sandra, Zachery, James, Meadors, Michael, Coco, Jeffrey, Sanders, Charles V, George, W. Lance, Gardner, Steven, Finegold, Sydney, Bernard, Gordon R, Bogden, Paul, Bello, Erlaine, Ellrodt, A. Gray, Dauer, Jan, Riedinger, Mary S, Meyers, Burt R, Iberti, Thomas, Rissing, J. Peter, Nelson, Donald, Luu, Quyen, Campbell, G. Douglas, Olsen, Keith, Carvalho, Alex, Brown, Arthur E, Schmitt, Heinz J, Brown, Sheldon, Schentag, Jerome J, Wels, Philip B, Wing, Patricia E, Welage, Lynda S, Quintiliani, Richard, Chandrasekar, P. H, Ratzan, Kenneth R, Dunn, David L, Gorelick, Kenneth, Wedel, Nancy, Saks, Samuel, Hannigan, John, Ackerman, Samuel K, Scannon, Patrick J, Salsburg, David, Webb, C. Douglas

“…Objective.—To assess the efficacy of adjunctive monoclonal antibody antiendotoxin immunotherapy in patients with gram-negative sepsis.Design.—Double-blind,…”
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Evaluation of a CD5-specific immunotoxin for treatment of acute graft- versus-host disease after allogeneic marrow transplantation by Martin, PJ, Nelson, BJ, Appelbaum, FR, Anasetti, C, Deeg, HJ, Hansen, JA, McDonald, GB, Nash, RA, Sullivan, KM, Witherspoon, RP, Scannon, PJ, Friedmann, N, Storb, R

“…Acute graft-versus-host disease (GVHD) is most often treated with high dose glucocorticoids, but less than half of patients have durable overall improvement…”
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ASSESSMENT OF CURRENT OUTCOMES AFTER BLOOD TRANSFUSION FOR POST-TRAUMATIC HEMORRHAGE: ANALYSIS OF A PROSPECTIVE CLINICAL TRIAL by Brathwaite, Collin E.M., Moncure, Michael, Huffman, Joan, Nelson, Betty, Scannon, Patrick J.

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Phase I/II Trial of rBPI-21 (a Recombinant 21kD Fragment of Bactericidal/Permeability-Increasing Protein) in Children with Severe Meningococcemia. † 196 by Kirsch, Erica A., Quint, Peter A., Carroll, Steve F., Scannon, Patrick J., Giroir, Brett P.

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Use of an Anti-Pan T-Lymphocyte Ricin A Chain Immunotoxin in Steroid-Resistant Acute Graft-Versus-Host Disease by Byers, Vera S., Henslee, P.Jean, Kernan, Nancy A., Blazar, Bruce Ft, Gingrich, Roger, Phillips, Gordon L., LeMaistre, C.F., Gilliland, Gary, Antin, Joseph H., Martin, Paul, Tutscha, Peter J., Trown, Patrick, Ackerman, Samuel K., O'Reilly, Richard J., Scannon, Patrick J.

“…Acute steroid-resistant graft-versus-host disease (AGVHD) after allogeneic bone marrow transplantation is frequently fatal. A new treatment for this…”
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Evaluation of a CD5-Specific Immunotoxin for Treatment of Acute Graft-Versus-Host Disease After Allogeneic Marrow Transplantation by Martin, Paul J., Nelson, Betty J., Appelbaum, Frederick R., Anasetti, Claudio, Deeg, H.Joachim, Hansen, John A., McDonald, George B., Nash, Richard A., Sullivan, Keith M., Witherspoon, Robert P., Scannon, Patrick J., Friedmann, Nadav, Storb, Rainer

“…Acute graft-versus-host disease (GVHD) is most often treated with high dose glucocorticoids, but less than half of patients have durable overall improvement…”
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Mediation of reduction of spontaneous and experimental pulmonary metastases by ricin A-chain immunotoxin 45-2D9-RTA with potentiation by systemic monensin in mice by ROTH, J. A, AMES, R. S, FRY, K, LEE, H. M, SCANNON, P. J

“…We developed a model to assess the therapeutic effects of the 45-2D9-ricin A-chain immunotoxin (RTA) on pulmonary metastases. The 45-2D9 mouse monoclonal…”
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