Search Results - "Scannell, Jack"

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis by Scannell, Jack W, Bosley, Jim

“…A striking contrast runs through the last 60 years of biopharmaceutical discovery, research, and development. Huge scientific and technological gains should…”
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Diagnosing the decline in pharmaceutical R&D efficiency by Scannell, Jack W., Blanckley, Alex, Boldon, Helen, Warrington, Brian

“…The number of new drugs approved per billion US dollars spent on research and development (R&D) has fallen around 80-fold in inflation-adjusted terms since…”
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Breaking Eroom’s Law by Ringel, Michael S., Scannell, Jack W., Baedeker, Mathias, Schulze, Ulrik

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Biopharmaceutical R&D outsourcing: Short-term gain for long-term pain? by Billette de Villemeur, Etienne, Scannell, Jack W., Versaevel, Bruno

“…•Since 1980, pharma has delivered much better financial returns than biotech despite ceding share of the pipeline and the end market for medicines.•Game theory…”
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Evidence for the effectiveness of minimum pricing of alcohol: a systematic review and assessment using the Bradford Hill criteria for causality by Boniface, Sadie, Scannell, Jack W, Marlow, Sally

“…ObjectivesTo assess the evidence for price-based alcohol policy interventions to determine whether minimum unit pricing (MUP) is likely to be…”
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Predictive validity in drug discovery: what it is, why it matters and how to improve it by Scannell, Jack W., Bosley, James, Hickman, John A., Dawson, Gerard R., Truebel, Hubert, Ferreira, Guilherme S., Richards, Duncan, Treherne, J. Mark

“…Successful drug discovery is like finding oases of safety and efficacy in chemical and biological deserts. Screens in disease models, and other decision tools…”
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Costs and Causes of Oncology Drug Attrition With the Example of Insulin-Like Growth Factor-1 Receptor Inhibitors by Jentzsch, Valerie, Osipenko, Leeza, Scannell, Jack W, Hickman, John A

“…The development of oncology drugs is expensive and beset by a high attrition rate. Analysis of the costs and causes of translational failure may help to reduce…”
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Regulatory and market influences on innovation pathways for the development of new antimicrobial drugs by Mittra, James, Bruce, Ann, Scannell, Jack W., Tait, Joyce

“…Focusing on Europe and the United States, and using policy/regulatory document analysis, qualitative interviews and quantitative cost-scenario analysis, we…”
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Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology by Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A., Carman, Christopher V., Chaff, Jake T., Heng, Anthony R., Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R., Kadam, Mahika M., Kanellias, Marianne, Kujala, Ville J., Kulkarni, Gauri, Le, Christopher Y., Lucchesi, Carolina, Manatakis, Dimitris V., Maniar, Kairav K., Quinn, Meaghan E., Ravan, Joseph S., Rizos, Ann Catherine, Sauld, John F. K., Sliz, Josiah D., Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E., Scannell, Jack W., Levner, Daniel

“…Background Conventional preclinical models often miss drug toxicities, meaning the harm these drugs pose to humans is only realized in clinical trials or when…”
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Estimating Prokaryotic Diversity and Its Limits by Curtis, Thomas P., Sloan, William T., Scannell, Jack W.

“…The absolute diversity of prokaryotes is widely held to be unknown and unknowable at any scale in any environment. However, it is not necessary to count every…”
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Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology by Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A., Carman, Christopher V., Chaff, Jake T., Heng, Anthony R., Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R., Kadam, Mahika M., Kanellias, Marianne, Kujala, Ville J., Kulkarni, Gauri, Le, Christopher Y., Lucchesi, Carolina, Manatakis, Dimitris V., Maniar, Kairav K., Quinn, Meaghan E., Ravan, Joseph S., Rizos, Ann Catherine, Sauld, John F. K., Sliz, Josiah D., Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E., Scannell, Jack W., Levner, Daniel

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Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology by Ewart, Lorna, Apostolou, Athanasia, Briggs, Skyler A., Carman, Christopher V., Chaff, Jake T., Heng, Anthony R., Jadalannagari, Sushma, Janardhanan, Jeshina, Jang, Kyung-Jin, Joshipura, Sannidhi R., Kadam, Mahika M., Kanellias, Marianne, Kujala, Ville J., Kulkarni, Gauri, Le, Christopher Y., Lucchesi, Carolina, Manatakis, Dimitris V., Maniar, Kairav K., Quinn, Meaghan E., Ravan, Joseph S., Rizos, Ann Catherine, Sauld, John F. K., Sliz, Josiah D., Tien-Street, William, Trinidad, Dennis Ramos, Velez, James, Wendell, Max, Irrechukwu, Onyi, Mahalingaiah, Prathap Kumar, Ingber, Donald E., Scannell, Jack W., Levner, Daniel

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'Maybe add something to it?': building on The Daily Mile to enhance enjoyment and engagement by Scannell, Jack, Murphy, Frances

“…The focus of this study is to investigate if a physical activity initiaitive (The Daily Mile) centred on running could be adapted to enhance primary school…”
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Prey scan at random to evade observant predators by Scannell, Jack, Roberts, Gilbert, Lazarus, John

“…Anti–predator scans by animals occur with very irregular timing, so that the initiation of scans resembles a random, Poisson–like, process. At first sight,…”
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Correlations, feature-binding and population coding in primary visual cortex by GOLLEDGE, Huw D. R, PANZERI, Stefano, FASHAN ZHENG, POLA, Gianni, SCANNELL, Jack W, GIANNIKOPOULOS, Dimitrios V, MASON, Roger J, TOVEE, Martin J, YOUNG, Malcolm P

“…To test the hypothesis that correlated neuronal activity serves as the neuronal code for visual feature binding, we applied information theory techniques to…”
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Regarding the editorial by Sau and Ng. ‘Hypertrophic cardiomyopathy risk stratification based on clinical or dynamic electrophysiological features: two sides of the same coin’ by Saumarez, Richard, Silberbauer, John, Scannell, Jack, Pytkowski, Mariusz, Peters, Nicolas

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Determining cortical landscapes by Scannell, Jack W

“…Data is presented to support Van Essen's Hypothesis about the folded surface of the cerebral cortex that is connected by a network of nerve fibers in the…”
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Patterns and Predictors of Professional Interpreter Use in the Pediatric Emergency Department by Lion, K Casey, Gritton, Jesse, Scannell, Jack, Brown, Julie C, Ebel, Beth E, Klein, Eileen J, Mangione-Smith, Rita

“…Professional interpretation for patients with limited English proficiency remains underused. Understanding predictors of use is crucial for intervention. We…”
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On imputing function to structure from the behavioural effects of brain lesions by Young, M. P., Young, Malcolm P., Hilgetag, Claus-C., Scannell, Jack W.

“…What is the link, if any, between the patterns of connections in the brain and the behavioural effects of localized brain lesions? We explored this question in…”
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Should lethal arrhythmias in hypertrophic cardiomyopathy be predicted using non-electrophysiological methods? by Saumarez, Richard, Silberbauer, John, Scannell, Jack, Pytkowski, Mariusz, Behr, Elijah R, Betts, Timothy, Della Bella, Paulo, Peters, Nicholas S

“…Abstract While sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) is due to arrhythmias, the guidelines for prediction of SCD are based solely on…”
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