Search Results - "Scammells, P J"

Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics by Cook, A E, Mistry, S N, Gregory, K J, Furness, S G B, Sexton, P M, Scammells, P J, Conigrave, A D, Christopoulos, A, Leach, K

“…Background and Purpose Clinical use of cinacalcet in hyperparathyroidism is complicated by its tendency to induce hypocalcaemia, arising partly from activation…”
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The dopamine D2 and adenosine A2A receptors: past, present and future trends for the treatment of Parkinson's disease by Jorg, M, Scammells, P J, Capuano, B

“…Herein, we present an overview of the historic development of drugs for the treatment of Parkinson's disease as well as prospective novel treatment forms based…”
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1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells by Belardinelli, L, Shryock, J C, Zhang, Y, Scammells, P J, Olsson, R, Dennis, D, Milner, P, Pfister, J, Baker, S P

“…The objective of this study was to characterize the adenosine receptor (AdoR) antagonistic properties of a newly synthesized alkylxanthine,…”
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Lanasol dyes and wool fibres. Part I: model studies on the mechanism of dye fixation in a mixed solvent system by Church, J.S., Davie, A.S., Scammells, P.J., Tucker, D.J.

“…The mechanism of fixation of Lanasol dyes, which are distinguished by their α-bromoacrylamido reactive group, to the various amino acid side chain sites within…”
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A(1) adenosine receptor agonists: medicinal chemistry and therapeutic potential by Hutchinson, S A, Scammells, P J

“…Adenosine receptors are widely distributed in the body and modulate numerous physiological processes. Four receptor subtypes (termed A(1), A(2A), A(2B) and…”
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Lanasol dyes and wool fibres. part II: model studies on the mechanism of dye fixation in an aqueous system by Church, J.S., Davie, A.S., Scammells, P.J., Tucker, D.J.

“…In Part I of this study we investigated the mechanism of the fixation of Lanasol dyes to the various amino acid side chain sites within wool protein using…”
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Crystal structure of 5-(3'-acetoxypropyl)-4-iodo-7-methoxy-2-phenyl-benzo[b]furan, C20H19IO4 by Scammells P. J., Tiekink E. R. T.

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Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor by Beauglehole, A R, Baker, S P, Scammells, P J

“…FSCPX (1) has been reported to be a potent, selective, and irreversible antagonist for the A(1)-adenosine receptor (AR). To obtain an irreversible A(1)AR…”
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Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine by Harden, Fiona A, Quinn, Ronald J, Scammells, Peter J

“…Pyrazolo[3,4-d]pyrimidines are pyrazolo analogues of purines. They have been shown to be a general class of compounds which exhibit A1 adenosine receptor…”
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Photochemical N-demethylation of alkaloids by Ripper, Justin A., Tiekink, Edward R.T., Scammells, Peter J.

“…Certain alkaloids were observed to undergo N-demethylation processes under photochemical conditions. Tropine, acetyltropine, tropinone, and atropine were…”
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A novel irreversible antagonist of the A1-adenosine receptor by Srinivas, M, Shryock, J C, Scammells, P J, Ruble, J, Baker, S P, Belardinelli, L

“…We determined the effects of 8-cyclopentyl-3-[3-[[4-(fluorosulfonyl)benzoyl]oxy]propyl]-1-propylxanth ine (FSCPX), a putative irreversible antagonist of the…”
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XH-14 analogues as adenosine antagonists by Scammells, P J, Baker, S P, Beauglehole, A R

“…Analogues of the potent adenosine antagonist 5-(3'-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'- hydroxyphenyl)benzo[b]furan-3-carbaldehyde (XH-14, 1) with…”
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Adenosine receptor ligands with oxygenated N6-substituents by HUTCHINSON, S. A, BAKER, S. P, SCAMMELLS, P. J

“…A number of novel adenosine analogs bearing oxygenated substituents in the N6-position have been prepared and evaluated as A1 adenosine agonists. Improved…”
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N6-(5,6-epoxynorbornyl)adenosine analogs as a1 adenosine agonists by WRIGHT, D. M. J, BAKER, S. P, STEWART, S. G, SCAMMELLS, P. J

“…A range of related adenosines and 5'-N-ethylcarboxamidoadenosines bearing oxygenated substituents in the N6 position have been synthesised and evaluated as…”
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A new synthesis of the benzofuran adenosine antagonist XH-14 by Hutchinson, Sally A., Luetjens, Henning, Scammells, Peter J.

“…5-(3-Hydroxypropyl)-7-methoxy-2-(3′-methoxy-4′-hydroxyphenyl)benzo[ b]furan-3-carbaldehyde (XH-14, 1) has been reported to be a potent A 1 adenosine…”
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Crystal structure of 4-(3'-acetoxypropyl)-6-bromo-2-methoxyphenol, С12Н15ВrО4 by Hutchinson S. Α., Scammells P. J., Tiekink E. R. T.

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The design and synthesis of novel adenosine agonists by Scammells, P.J., Baker, S.P., Bellardinelli, L., Olsson, R.A., Russell, R.A., Knevitt, S.A.

“…The 2 R and 2 S- endo isomers of N 6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A 1 adenosine receptor. The…”
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Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies by Sahbaz, Yasemin, Nguyen, Tri-Hung, Ford, Leigh, McEvoy, Claire L, Williams, Hywel D, Scammells, Peter J, Porter, Christopher J. H

“…This study aimed to transform weakly acidic poorly water-soluble drugs (PWSD) into ionic liquids (ILs) to promote solubility in, and the utility of,…”
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Further investigation of the N-demethylation of tertiary amine alkaloids using the non-classical Polonovski reaction by Thavaneswaran, Shanti, Scammells, Peter J.

“…The iron salt-mediated Polonovski reaction efficiently N-demethylates certain opiate alkaloids. In this process, the use of the hydrochloride salt of the…”
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Fluorosulfonyl-Substituted Xanthines as Selective Irreversible Antagonists for the A1-Adenosine Receptor by Beauglehole, Anthony R, Baker, Stephen P, Scammells, Peter J

“…FSCPX (1) has been reported to be a potent, selective, and irreversible antagonist for the A1-adenosine receptor (AR). To obtain an irreversible A1AR…”
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