Search Results - "Scally, Stephen W"

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs by Murugan, Rajagopal, Scally, Stephen W., Costa, Giulia, Mustafa, Ghulam, Thai, Elaine, Decker, Tizian, Bosch, Alexandre, Prieto, Katherine, Levashina, Elena A., Julien, Jean-Philippe, Wardemann, Hedda

“…The circumsporozoite protein of the human malaria parasite Plasmodium falciparum (PfCSP) is the main target of antibodies that prevent the infection and…”
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A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis by Scally, Stephen W, Petersen, Jan, Law, Soi Cheng, Dudek, Nadine L, Nel, Hendrik J, Loh, Khai Lee, Wijeyewickrema, Lakshmi C, Eckle, Sidonia B G, van Heemst, Jurgen, Pike, Robert N, McCluskey, James, Toes, Rene E, La Gruta, Nicole L, Purcell, Anthony W, Reid, Hugh H, Thomas, Ranjeny, Rossjohn, Jamie

“…Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and…”
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The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis by Ting, Yi Tian, Petersen, Jan, Ramarathinam, Sri H., Scally, Stephen W., Loh, Khai L., Thomas, Ranjeny, Suri, Anish, Baker, Daniel G., Purcell, Anthony W., Reid, Hugh H., Rossjohn, Jamie

“…The HLA-DRB1 locus is strongly associated with rheumatoid arthritis (RA) susceptibility, whereupon citrullinated self-peptides bind to HLA-DR molecules bearing…”
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Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion by Triglia, Tony, Scally, Stephen W., Seager, Benjamin A., Pasternak, Michał, Dagley, Laura F., Cowman, Alan F.

“…Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain…”
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Biased T Cell Receptor Usage Directed against Human Leukocyte Antigen DQ8-Restricted Gliadin Peptides Is Associated with Celiac Disease by Broughton, Sophie E., Petersen, Jan, Theodossis, Alex, Scally, Stephen W., Loh, Khai Lee, Thompson, Allan, van Bergen, Jeroen, Kooy-Winkelaar, Yvonne, Henderson, Kate N., Beddoe, Travis, Tye-Din, Jason A., Mannering, Stuart I., Purcell, Anthony W., McCluskey, James, Anderson, Robert P., Koning, Frits, Reid, Hugh H., Rossjohn, Jamie

“…Celiac disease is a human leukocyte antigen (HLA)-DQ2- and/or DQ8-associated T cell-mediated disorder that is induced by dietary gluten. Although it is…”
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Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25 by Scally, Stephen W., McLeod, Brandon, Bosch, Alexandre, Miura, Kazutoyo, Liang, Qi, Carroll, Sean, Reponen, Sini, Nguyen, Ngan, Giladi, Eldar, Rämisch, Sebastian, Yusibov, Vidadi, Bradley, Allan, Lemiale, Franck, Schief, William R., Emerling, Daniel, Kellam, Paul, King, C. Richter, Julien, Jean-Philippe

“…The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies…”
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Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25 by McLeod, Brandon, Miura, Kazutoyo, Scally, Stephen W., Bosch, Alexandre, Nguyen, Ngan, Shin, Hanjun, Kim, Dongkyoon, Volkmuth, Wayne, Rämisch, Sebastian, Chichester, Jessica A., Streatfield, Stephen, Woods, Colleen, Schief, William R., Emerling, Daniel, King, C. Richter, Julien, Jean-Philippe

“…Transmission-blocking vaccines have the potential to be key contributors to malaria elimination. Such vaccines elicit antibodies that inhibit parasites during…”
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High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire by Kucharska, Iga, Binter, Špela, Murugan, Rajagopal, Scally, Stephen W, Ludwig, Julia, Prieto, Katherine, Thai, Elaine, Costa, Giulia, Li, Kan, Horn, Gillian Q, Flores-Garcia, Yevel, Bosch, Alexandre, Sicard, Taylor, Rubinstein, John L, Zavala, Fidel, Dennison, S Moses, Tomaras, Georgia D, Levashina, Elena A, Kellam, Paul, Wardemann, Hedda, Julien, Jean-Philippe

“…Antibodies targeting the human malaria parasite Plasmodium falciparum circumsporozoite protein (PfCSP) can prevent infection and disease. PfCSP contains…”
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Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model by Ludwig, Julia, Scally, Stephen W., Costa, Giulia, Hoffmann, Sandro, Murugan, Rajagopal, Lossin, Jana, Prieto, Katherine, Obraztsova, Anna, Lobeto, Nina, Franke-Fayard, Blandine, Janse, Chris J., Lebas, Celia, Collin, Nicolas, Binter, Spela, Kellam, Paul, Levashina, Elena A., Wardemann, Hedda, Julien, Jean-Philippe

“…The development of an effective and durable vaccine remains a central goal in the fight against malaria. Circumsporozoite protein (CSP) is the major surface…”
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Author Correction: Glycosylated nanoparticle-based PfCSP vaccine confers long-lasting antibody responses and sterile protection in mouse malaria model by Ludwig, Julia, Scally, Stephen W., Costa, Giulia, Hoffmann, Sandro, Murugan, Rajagopal, Lossin, Jana, Prieto, Katherine, Obraztsova, Anna, Lobeto, Nina, Franke-Fayard, Blandine, Janse, Chris J., Lebas, Celia, Collin, Nicolas, Binter, Spela, Kellam, Paul, Levashina, Elena A., Wardemann, Hedda, Julien, Jean-Philippe

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Substrate-mediated Stabilization of a Tetrameric Drug Target Reveals Achilles Heel in Anthrax by Voss, Jarrod E., Scally, Stephen W., Taylor, Nicole L., Atkinson, Sarah C., Griffin, Michael D.W., Hutton, Craig A., Parker, Michael W., Alderton, Malcolm R., Gerrard, Juliet A., Dobson, Renwick C.J., Dogovski, Con, Perugini, Matthew A.

“…Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax. With the increased threat of anthrax in biowarfare, there is an urgent need…”
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Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies by Triller, Gianna, Scally, Stephen W., Costa, Giulia, Pissarev, Maria, Kreschel, Cornelia, Bosch, Alexandre, Marois, Eric, Sack, Brandon K., Murugan, Rajagopal, Salman, Ahmed M., Janse, Chris J., Khan, Shahid M., Kappe, Stefan H.I., Adegnika, Ayola A., Mordmüller, Benjamin, Levashina, Elena A., Julien, Jean-Philippe, Wardemann, Hedda

“…Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from…”
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Peek-Peak-Pique: Repeating Motifs of Subtle Variance Are Targets for Potent Malaria Antibodies by Scally, Stephen W., Julien, Jean-Philippe

“…Biomedical interventions to curb malaria-causing Plasmodium falciparum (Pf) infections are critically needed. Two studies in Nature Medicine,Kisalu et al…”
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Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope by Imkeller, Katharina, Scally, Stephen W, Bosch, Alexandre, Martí, Gemma Pidelaserra, Costa, Giulia, Triller, Gianna, Murugan, Rajagopal, Renna, Valerio, Jumaa, Hassan, Kremsner, Peter G, Sim, B Kim Lee, Hoffman, Stephen L, Mordmüller, Benjamin, Levashina, Elena A, Julien, Jean-Philippe, Wardemann, Hedda

“…Affinity maturation selects B cells expressing somatically mutated antibody variants with improved antigen-binding properties to protect from invading…”
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Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection by Scally, Stephen W, Murugan, Rajagopal, Bosch, Alexandre, Triller, Gianna, Costa, Giulia, Mordmüller, Benjamin, Kremsner, Peter G, Sim, B Kim Lee, Hoffman, Stephen L, Levashina, Elena A, Wardemann, Hedda, Julien, Jean-Philippe

“…Antibodies against the central repeat of the (Pf) circumsporozoite protein (CSP) inhibit parasite activity and correlate with protection from malaria. However,…”
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A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity by Thai, Elaine, Costa, Giulia, Weyrich, Anna, Murugan, Rajagopal, Oyen, David, Flores-Garcia, Yevel, Prieto, Katherine, Bosch, Alexandre, Valleriani, Angelo, Wu, Nicholas C, Pholcharee, Tossapol, Scally, Stephen W, Wilson, Ian A, Wardemann, Hedda, Julien, Jean-Philippe, Levashina, Elena A

“…Malaria is a global health concern, and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a…”
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PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum by Scally, Stephen W., Triglia, Tony, Evelyn, Cindy, Seager, Benjamin A., Pasternak, Michał, Lim, Pailene S., Healer, Julie, Geoghegan, Niall D., Adair, Amy, Tham, Wai-Hong, Dagley, Laura F., Rogers, Kelly L., Cowman, Alan F.

“…The most severe form of malaria is caused by Plasmodium falciparum . These parasites invade human erythrocytes, and an essential step in this process involves…”
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Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis by Scally, Stephen W, Law, Soi-Cheng, Ting, Yi Tian, Heemst, Jurgen van, Sokolove, Jeremy, Deutsch, Aaron J, Bridie Clemens, E, Moustakas, Antonis K, Papadopoulos, George K, van der Woude, Diane, Smolik, Irene, Hitchon, Carol A, Robinson, David B, Ferucci, Elizabeth D, Bernstein, Charles N, Meng, Xiaobo, Anaparti, Vidyanand, Huizinga, Tom, Kedzierska, Katherine, Reid, Hugh H, Raychaudhuri, Soumya, Toes, René E, Rossjohn, Jamie, El-Gabalawy, Hani, Thomas, Ranjeny

“…The pathogenetic mechanisms by which alleles are associated with anticitrullinated peptide antibody (ACPA)-positive rheumatoid arthritis (RA) are incompletely…”
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Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs by Chamoto, Kenji, Guo, Tingxi, Scally, Stephen W, Kagoya, Yuki, Anczurowski, Mark, Wang, Chung-Hsi, Rahman, Muhammed A, Saso, Kayoko, Butler, Marcus O, Chiu, Priscilla P L, Julien, Jean-Philippe, Hirano, Naoto

“…The human invariant NK (iNK) TCR is largely composed of the invariant TCR Vα24-Jα18 chain and semivariant TCR Vβ11 chains with variable CDR3β sequences. The…”
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Correction: Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs by Chamoto, Kenji, Guo, Tingxi, Scally, Stephen W, Kagoya, Yuki, Anczurowski, Mark, Wang, Chung-Hsi, Rahman, Muhammed A, Saso, Kayoko, Butler, Marcus O, Chiu, Priscilla P L, Julien, Jean-Philippe, Hirano, Naoto

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