Search Results - "Scally, Aylwyn"

The mutation rate in human evolution and demographic inference by Scally, Aylwyn

“…The germline mutation rate has long been a major source of uncertainty in human evolutionary and demographic analyses based on genetic data, but estimates have…”
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What is ancestry? by Mathieson, Iain, Scally, Aylwyn

“…Sophisticated methods have been developed to infer and visualise these relationships. [...]it seems that both scientists and the wider public are learning more…”
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Revising the human mutation rate: implications for understanding human evolution by Scally, Aylwyn, Durbin, Richard

“…Recent measurements of the human mutation rate using next-generation sequencing have revealed a value of approximately half of that previously derived from…”
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BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data by Narasimhan, Vagheesh, Danecek, Petr, Scally, Aylwyn, Xue, Yali, Tyler-Smith, Chris, Durbin, Richard

“…Runs of homozygosity (RoHs) are genomic stretches of a diploid genome that show identical alleles on both chromosomes. Longer RoHs are unlikely to have arisen…”
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Reforming social genetics by Scally, Aylwyn

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Global clues to the nature of genomic mutations in humans by Scally, Aylwyn

“…An analysis of worldwide human genetic variation reveals the footprints of ancient changes in genomic mutation processes…”
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Inference of Candidate Germline Mutator Loci in Humans from Genome-Wide Haplotype Data by Seoighe, Cathal, Scally, Aylwyn

“…The rate of germline mutation varies widely between species but little is known about the extent of variation in the germline mutation rate between individuals…”
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Detecting archaic introgression using an unadmixed outgroup by Skov, Laurits, Hui, Ruoyun, Shchur, Vladimir, Hobolth, Asger, Scally, Aylwyn, Schierup, Mikkel Heide, Durbin, Richard

“…Human populations outside of Africa have experienced at least two bouts of introgression from archaic humans, from Neanderthals and Denisovans. In Papuans…”
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Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding by Xue, Yali, Prado-Martinez, Javier, Sudmant, Peter H., Narasimhan, Vagheesh, Ayub, Qasim, Szpak, Michal, Frandsen, Peter, Chen, Yuan, Yngvadottir, Bryndis, Cooper, David N., de Manuel, Marc, Hernandez-Rodriguez, Jessica, Lobon, Irene, Siegismund, Hans R., Pagani, Luca, Quail, Michael A., Hvilsom, Christina, Mudakikwa, Antoine, Eichler, Evan E., Cranfield, Michael R., Marques-Bonet, Tomas, Tyler-Smith, Chris, Scally, Aylwyn

“…Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and…”
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Short-range template switching in great ape genomes explored using pair hidden Markov models by Walker, Conor R, Scally, Aylwyn, De Maio, Nicola, Goldman, Nick

“…Many complex genomic rearrangements arise through template switch errors, which occur in DNA replication when there is a transient polymerase switch to an…”
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Tracing the Route of Modern Humans out of Africa by Using 225 Human Genome Sequences from Ethiopians and Egyptians by Pagani, Luca, Schiffels, Stephan, Gurdasani, Deepti, Danecek, Petr, Scally, Aylwyn, Chen, Yuan, Xue, Yali, Haber, Marc, Ekong, Rosemary, Oljira, Tamiru, Mekonnen, Ephrem, Luiselli, Donata, Bradman, Neil, Bekele, Endashaw, Zalloua, Pierre, Durbin, Richard, Kivisild, Toomas, Tyler-Smith, Chris

“…The predominantly African origin of all modern human populations is well established, but the route taken out of Africa is still unclear. Two alternative…”
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Rethinking the dispersal of Homo sapiens out of Africa by Groucutt, Huw S., Petraglia, Michael D., Bailey, Geoff, Scerri, Eleanor M. L., Parton, Ash, Clark-Balzan, Laine, Jennings, Richard P., Lewis, Laura, Blinkhorn, James, Drake, Nick A., Breeze, Paul S., Inglis, Robyn H., Devès, Maud H., Meredith-Williams, Matthew, Boivin, Nicole, Thomas, Mark G., Scally, Aylwyn

“…Current fossil, genetic, and archeological data indicate that Homo sapiens originated in Africa in the late Middle Pleistocene. By the end of the Late…”
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Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes by Narasimhan, Vagheesh M., Rahbari, Raheleh, Scally, Aylwyn, Wuster, Arthur, Mason, Dan, Xue, Yali, Wright, John, Trembath, Richard C., Maher, Eamonn R., van Heel, David A., Auton, Adam, Hurles, Matthew E., Tyler-Smith, Chris, Durbin, Richard

“…Heterozygous mutations within homozygous sequences descended from a recent common ancestor offer a way to ascertain de novo mutations across multiple…”
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A new isolation with migration model along complete genomes infers very different divergence processes among closely related great ape species by Mailund, Thomas, Halager, Anders E, Westergaard, Michael, Dutheil, Julien Y, Munch, Kasper, Andersen, Lars N, Lunter, Gerton, Prüfer, Kay, Scally, Aylwyn, Hobolth, Asger, Schierup, Mikkel H

“…We present a hidden Markov model (HMM) for inferring gradual isolation between two populations during speciation, modelled as a time interval with restricted…”
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A genome-wide survey of genetic variation in gorillas using reduced representation sequencing by Scally, Aylwyn, Yngvadottir, Bryndis, Xue, Yali, Ayub, Qasim, Durbin, Richard, Tyler-Smith, Chris

“…All non-human great apes are endangered in the wild, and it is therefore important to gain an understanding of their demography and genetic diversity. Whole…”
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Mutation rates and the evolution of germline structure by Scally, Aylwyn

“…Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities in our understanding of human germline mutation. In particular,…”
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Genomes reveal marked differences in the adaptive evolution between orangutan species by Mattle-Greminger, Maja P, Bilgin Sonay, Tugce, Nater, Alexander, Pybus, Marc, Desai, Tariq, de Valles, Guillem, Casals, Ferran, Scally, Aylwyn, Bertranpetit, Jaume, Marques-Bonet, Tomas, van Schaik, Carel P, Anisimova, Maria, Krützen, Michael

“…Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known…”
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Newfound differences between great apes by Scally, Aylwyn

“…In apes, such repetitive DNA comprises a substantial fraction of the genome. Because of these difficulties, the first greatape genome projects used the human…”
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High-quality genomes reveal new differences between the great apes by Scally, Aylwyn

“…High-quality genome sequences for some of the great apes have been assembled using state-of-the-art sequencing tools. The assemblies provide an unbiased…”
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Mutation rates and the evolution of germline structure by Scally, Aylwyn

“…Genome sequencing studies of de novo mutations in humans have revealed surprising incongruities in our understanding of human germline mutation. In particular,…”
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