Search Results - "Scales, S J"

SNARE complex formation is triggered by Ca2+ and drives membrane fusion by Chen, Y A, Scales, S J, Patel, S M, Doung, Y C, Scheller, R H

“…Neurotransmitter exocytosis, a process mediated by a core complex of syntaxin, SNAP-25, and VAMP (SNAREs), is inhibited by SNARE-cleaving neurotoxins…”
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Visualization of ER-to-Golgi Transport in Living Cells Reveals a Sequential Mode of Action for COPII and COPI by Scales, Suzie J., Pepperkok, Rainer, Kreis, Thomas E.

“…Exocytic transport from the endoplasmic reticulum (ER) to the Golgi complex has been visualized in living cells using a chimera of the temperature-sensitive…”
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Sequential SNARE Assembly Underlies Priming and Triggering of Exocytosis by Chen, Yu A., Scales, Suzie J., Scheller, Richard H.

“…Changes in SNARE conformations during MgATP-dependent priming of cracked PC12 cells were probed by their altered accessibility to various inhibitors. Dominant…”
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SNAREs Contribute to the Specificity of Membrane Fusion by Scales, Suzie J., Chen, Yu A., Yoo, Bryan Y., Patel, Sejal M., Doung, Yee-Cheen, Scheller, Richard H.

“…Intracellular membrane fusion is mediated by the formation of a four-helix bundle comprised of SNARE proteins. Every cell expresses a large number of SNARE…”
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Amisyn, a Novel Syntaxin-binding Protein That May Regulate SNARE Complex Assembly by Scales, Suzie J., Hesser, Boris A., Masuda, Esteban S., Scheller, Richard H.

“…The regulation of SNARE complex assembly likely plays an important role in governing the specificity as well as the timing of membrane fusion. Here we identify…”
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Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes by Shima, David T., Scales, Suzie J., Kreis, Thomas E., Pepperkok, Rainer

“…Membrane traffic between the endoplasmic reticulum (ER) and the Golgi complex is regulated by two vesicular coat complexes, COPII and COPI. COPII has been…”
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The Ionic Layer is Required for Efficient Dissociation of the SNARE Complex by α-SNAP and NSF by Scales, Suzie J., Yoo, Bryan Y., Scheller, Richard H.

“…The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular…”
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Cell biology. Fusion without SNAREs? by Scales, S J, Finley, M F, Scheller, R H

“…Highly orchestrated molecular rearrangements are required for two membranes to fuse, as happens, for example, during neurotransmitter release into the synapse…”
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Calcium Regulation of Exocytosis in PC12 Cells by Chen, Yu A., Scales, Suzie J., Duvvuri, Vikas, Murthy, Mala, Patel, Sejal M., Schulman, Howard, Scheller, Richard H.

“…The calcium (Ca2+) regulation of neurotransmitter release is poorly understood. Here we investigated several aspects of this process in PC12 cells. We first…”
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A Discontinuous SNAP-25 C-terminal Coil Supports Exocytosis by Chen, Y A, Scales, S J, Jagath, J R, Scheller, R H

“…Membrane fusion requires the formation of four-helical bundles comprised of the SNARE proteins syntaxin, vesicle-associated membrane protein (VAMP), and the…”
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Membrane Recruitment of Coatomer and Binding to Dilysine Signals Are Separate Events by Gomez, M, Scales, S J, Kreis, T E, Perez, F

“…It has previously been shown that transport of newly synthesized proteins and the structure of the Golgi complex are affected in the Chinese hamster ovary cell…”
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A Formiminotransferase Cyclodeaminase Isoform Is Localized to the Golgi Complex and Can Mediate Interaction of Trans-Golgi Network-derived Vesicles with Microtubules by Hennig, Dagmar, Scales, Suzie J., Moreau, Anne, Murley, Laura L., De Mey, Jan, Kreis, Thomas E.

“…A protein of 60 kDa (p60) has been identified using a quantitative in vitro vesicle-microtubule binding assay. Purified p60 induces co-sedimentation with…”
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Oxidizing Potential of Endosomes and Lysosomes Limits Intracellular Cleavage of Disulfide-Based Antibody-Drug Conjugates by Austin, Cary D., Xiaohui Wen, Lewis Gazzard, Nelson, Christopher, Scheller, Richard H., Scales, Suzie J.

“…Antibody-drug conjugate therapy entails targeted killing of cancer cells with cytotoxic compounds covalently linked to tumor-specific antibodies and shows…”
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Coat proteins regulating membrane traffic by Scales, S J, Gomez, M, Kreis, T E

“…This review focuses on the roles of coat proteins in regulating the membrane traffic of eukaryotic cells. Coat proteins are recruited to the donor organelle…”
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Lipid membranes shape up by Scales, S J, Scheller, R H

“…Schmidt et al offer an exciting insight into the main pathway by which synaptic vesicles are recycled, a process called clathrin-mediated endocytosis…”
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Perspectives in cell biology: Fusion without SNAREs? by Scales, S J, Finley, MFA, Scheller, R H

“…The organization of cellular organelles depends on regulating the mixing of specific membrane compartments through modulation of membrane fusion. Nowhere is…”
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CRIg: A Macrophage Complement Receptor Required for Phagocytosis of Circulating Pathogens by Helmy, Karim Y., Katschke, Kenneth J., Gorgani, Nick N., Kljavin, Noelyn M., Elliott, J. Michael, Diehl, Lauri, Scales, Suzie J., Ghilardi, Nico, van Lookeren Campagne, Menno

“…The complement system serves an important role in clearance of pathogens, immune complexes, and apoptotic cells present in the circulation. Complement…”
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Fusion without SNAREs? by Scales, Suzie J., Michael F. A. Finley, Scheller, Richard H.

“…The organization of cellular organelles depends on regulating the mixing of specific membrane compartments through modulation of membrane fusion. All…”
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The specifics of membrane fusion by Scales, S J, Bock, J B, Scheller, R H

“…The ability to maintain a diverse set of intracellular compartments, with distinct complements of proteins, is a defining feature of eukaryotic cells…”
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SNARE Complex Formation Is Triggered by Ca super(2+) and Drives Membrane Fusion by Chen, Yu A, Scales, S J, Patel, S M, Doung, Yee-Cheen, Scheller, R H

“…Neurotransmitter exocytosis, a process mediated by a core complex of syntaxin, SNAP-25, and VAMP (SNAREs), is inhibited by SNARE-cleaving neurotoxins…”
Get full text