Search Results - "Scaini, Denis"
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Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment
Published in ACS nano (27-11-2018)“…Graphene and its derivatives are heralded as “miracle” materials with manifold applications in different sectors of society from electronics to energy storage…”
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Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
Published in Nature communications (07-08-2020)“…TP53 missense mutations leading to the expression of mutant p53 oncoproteins are frequent driver events during tumorigenesis. p53 mutants promote tumor growth,…”
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Advances in Nano Neuroscience: From Nanomaterials to Nanotools
Published in Frontiers in neuroscience (15-01-2019)“…During the last decades, neuroscientists have increasingly exploited a variety of artificial, synthesized materials with controlled nano-sized features. For…”
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Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts
Published in Nature nanotechnology (01-02-2009)“…Carbon nanotubes have been applied in several areas of nerve tissue engineering to probe and augment cell behaviour, to label and track subcellular components,…”
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BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses
Published in Molecular brain (17-03-2020)“…Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute…”
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Mapping mechanical properties of living cells at nanoscale using intrinsic nanopipette-sample force interactions
Published in Nanoscale (07-04-2021)“…Mechanical properties of living cells determined by cytoskeletal elements play a crucial role in a wide range of biological functions. However, low-stress…”
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Adhesion to carbon nanotube conductive scaffolds forces action-potential appearance in immature rat spinal neurons
Published in PloS one (12-08-2013)“…In the last decade, carbon nanotube growth substrates have been used to investigate neurons and neuronal networks formation in vitro when guided by artificial…”
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The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein
Published in PloS one (21-11-2017)“…Humic substances (HS) are the largest constituent of soil organic matter and are considered as a key component of the terrestrial ecosystem. HS may facilitate…”
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Bidirectional Modulation of Neuronal Cells Electrical and Mechanical Properties Through Pristine and Functionalized Graphene Substrates
Published in Frontiers in neuroscience (11-01-2022)“…In recent years, the quest for surface modifications to promote neuronal cell interfacing and modulation has risen. This course is justified by the…”
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Prion protein interaction with soil humic substances: environmental implications
Published in PloS one (17-06-2014)“…Transmissible spongiform encephalopathies (TSE) are fatal neurodegenerative disorders caused by prions. Animal TSE include scrapie in sheep and goats, and…”
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Carbon Nanotubes Substrates Alleviate Pro-Calcific Evolution in Porcine Valve Interstitial Cells
Published in Nanomaterials (Basel, Switzerland) (15-10-2021)“…The quest for surfaces able to interface cells and modulate their functionality has raised, in recent years, the development of biomaterials endowed with…”
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Electron Transfer Mediating Properties of Hydrocarbons as a Function of Chain Length: A Differential Scanning Conductive Tip Atomic Force Microscopy Investigation
Published in ACS nano (01-03-2008)“…The development of novel molecular and biomolecular devices relies on the understanding of charge transport across molecule-substrate interfaces. However,…”
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13
Myoblast adhesion, proliferation and differentiation on human elastin-like polypeptide (HELP) hydrogels
Published in Journal of applied biomaterials & functional materials (26-01-2017)“…The biochemical, mechanical and topographic properties of extracellular matrix are crucially involved in determining skeletal muscle cell morphogenesis,…”
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Nanomaterials at the neural interface
Published in Current opinion in neurobiology (01-06-2018)“…•The use of electrical stimulation to treat pathological processes is termed ‘electroceuticals’.•Electrical brain stimulation is the new frontier to treat…”
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Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays
Published in ACS omega (30-06-2017)“…Early detection of cancer plays a crucial role in disease prognosis. It requires the recognition and quantification of low amounts of specific molecular…”
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Substrate roughness influence on the order of nanografted Self-Assembled Monolayers
Published in Chemical physics letters (16-09-2022)“…[Display omitted] •The role of the substrate roughness in the packing order of the Self-Assembly Monolayers is clearly identify;•Phase imaging in Atomic and…”
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Single-layer graphene modulates neuronal communication and augments membrane ion currents
Published in Nature nanotechnology (01-08-2018)“…The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed…”
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From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks
Published in Scientific reports (24-04-2015)“…To recreate in vitro 3D neuronal circuits will ultimately increase the relevance of results from cultured to whole-brain networks and will promote enabling…”
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Iron Mediated Interaction of Alpha Synuclein with Lipid Rafts in Model Membrane Systems
Published in Biophysical journal (02-02-2018)Get full text
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Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis
Published in Nature cell biology (01-01-2018)“…Tumour-associated p53 missense mutants act as driver oncogenes affecting cancer progression, metastatic potential and drug resistance (gain-of-function) 1 …”
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