Search Results - "Scahill, Rachael I."

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis by Byrne, Lauren M, MRes, Rodrigues, Filipe B, MD, Blennow, Kaj, Prof, Durr, Alexandra, Prof, Leavitt, Blair R, Prof, Roos, Raymund A C, Prof, Scahill, Rachael I, PhD, Tabrizi, Sarah J, Prof, Zetterberg, Henrik, Prof, Langbehn, Douglas, Prof, Wild, Edward J, Dr

“…Summary Background Blood biomarkers of neuronal damage could facilitate clinical management of and therapeutic development for Huntington's disease. We…”
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Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Owen, Gail, PhD, Durr, Alexandra, MD, Leavitt, Blair R, MDCM, Roos, Raymund A, Prof, Borowsky, Beth, PhD, Landwehrmeyer, Bernhard, Prof, Frost, Chris, Prof, Johnson, Hans, PhD, Craufurd, David, MD, Reilmann, Ralf, MD, Stout, Julie C, Prof, Langbehn, Douglas R, Prof

“…Summary Background TRACK-HD is a multinational prospective observational study of Huntington's disease (HD) that examines clinical and biological findings of…”
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Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis by Tabrizi, Sarah J, Prof, Scahill, Rachael I, PhD, Durr, Alexandra, MD, Roos, Raymund AC, MD, Leavitt, Blair R, FRCPC, Jones, Rebecca, MSc, Landwehrmeyer, G Bernhard, MD, Fox, Nick C, MD, Johnson, Hans, PhD, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Craufurd, David, FRCPsych, Frost, Chris, PhD, Langbehn, Douglas R, MD, Reilmann, Ralf, MD, Stout, Julie C, PhD

“…Summary Background TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals…”
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Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers by Politis, Marios, Lahiri, Nayana, Niccolini, Flavia, Su, Paul, Wu, Kit, Giannetti, Paolo, Scahill, Rachael I, Turkheimer, Federico E, Tabrizi, Sarah J, Piccini, Paola

“…Abstract Previous studies have shown activation of the immune system and altered immune response in Huntington's disease (HD) gene carriers. Here, we…”
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In vivo characterization of white matter pathology in premanifest huntington's disease by Zhang, Jiaying, Gregory, Sarah, Scahill, Rachael I., Durr, Alexandra, Thomas, David L., Lehericy, Stéphane, Rees, Geraint, Tabrizi, Sarah J., Zhang, Hui

“…Objective Huntington's disease (HD) is a monogenic, fully penetrant neurodegenerative disorder, providing an ideal model for understanding brain changes…”
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Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data by Tabrizi, Sarah J, Prof, Reilmann, Ralf, MD, Roos, Raymund AC, MD, Durr, Alexandra, MD, Leavitt, Blair, FRCP, Owen, Gail, PhD, Jones, Rebecca, MSc, Johnson, Hans, PhD, Craufurd, David, FRCPsych, Hicks, Stephen L, PhD, Kennard, Christopher, FRCP, Landwehrmeyer, Bernhard, MD, Stout, Julie C, PhD, Borowsky, Beth, PhD, Scahill, Rachael I, PhD, Frost, Chris, MA, Langbehn, Douglas R, PhD

“…Summary Background TRACK-HD is a prospective observational biomarker study in premanifest and early Huntington's disease (HD). In this report we define a…”
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Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data by Tabrizi, Sarah J, Langbehn, Douglas R, Leavitt, Blair R, Roos, Raymund AC, Durr, Alexandra, Craufurd, David, Kennard, Christopher, Hicks, Stephen L, Fox, Nick C, Scahill, Rachael I, Borowsky, Beth, Tobin, Allan J, Rosas, H Diana, Johnson, Hans, Reilmann, Ralf, Landwehrmeyer, Bernhard, Stout, Julie C

“…Summary Background Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in…”
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Fronto-striatal circuits for cognitive flexibility in far from onset Huntington’s disease: evidence from the Young Adult Study by Langley, Christelle, Gregory, Sarah, Osborne-Crowley, Katie, O'Callaghan, Claire, Zeun, Paul, Lowe, Jessica, Johnson, Eileanoir B, Papoutsi, Marina, Scahill, Rachael I, Rees, Geraint, Tabrizi, Sarah J, Robbins, Trevor W, Sahakian, Barbara Jacquelyn

“…ObjectivesCognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest…”
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A meta-analysis of hippocampal atrophy rates in Alzheimer's disease by Barnes, Josephine, Bartlett, Jonathan W, van de Pol, Laura A, Loy, Clement T, Scahill, Rachael I, Frost, Chris, Thompson, Paul, Fox, Nick C

“…Abstract Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD). However, cohorts and methods used to determine such…”
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Forecasting individual progression trajectories in Huntington disease enables more powered clinical trials by Koval, Igor, Dighiero-Brecht, Thomas, Tobin, Allan J., Tabrizi, Sarah J., Scahill, Rachael I., Tezenas du Montcel, Sophie, Durrleman, Stanley, Durr, Alexandra

“…Variability in neurodegenerative disease progression poses great challenges for the evaluation of potential treatments. Identifying the persons who will…”
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Operationalizing compensation over time in neurodegenerative disease by Gregory, Sarah, Long, Jeffrey D, Klöppel, Stefan, Razi, Adeel, Scheller, Elisa, Minkova, Lora, Papoutsi, Marina, Mills, James A, Durr, Alexandra, Leavitt, Blair R, Roos, Raymund A C, Stout, Julie C, Scahill, Rachael I, Langbehn, Douglas R, Tabrizi, Sarah J, Rees, Geraint

“…In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al …”
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Brain Regions Showing White Matter Loss in Huntington’s Disease Are Enriched for Synaptic and Metabolic Genes by McColgan, Peter, Gregory, Sarah, Seunarine, Kiran K., Razi, Adeel, Papoutsi, Marina, Johnson, Eileanoir, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Holmans, Peter, Scahill, Rachael I., Clark, Chris A., Rees, Geraint, Tabrizi, Sarah J., Coleman, A., Decolongon, J., Fan, M., Petkau, T., Jauffret, C., Justo, D., Lehericy, S., Nigaud, K., Valabrègue, R., Schoonderbeek, A., ‘t Hart, E.P., Moss, D. J. Hensman, Ghosh, R., Crawford, H., Papoutsi, M., Berna, C., Mahaleskshmi, D., Reilmann, R., Weber, N., Labuschagne, I., Stout, J., Landwehrmeyer, B., Orth, M., Mayer, I., Johnson, H., Crawfurd, D.

“…The earliest white matter changes in Huntington’s disease are seen before disease onset in the premanifest stage around the striatum, within the corpus…”
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Lumbar puncture safety and tolerability in premanifest and manifest Huntington’s disease: a multi-analysis cross-sectional study by Hassan, Yara Refaat, Brogueira Rodrigues, Filipe, Zeun, Paul, Byrne, Lauren M., Estevez-Fraga, Carlos, Tortelli, Rosanna, Scahill, Rachael I., Wild, Edward J., Tabrizi, Sarah J.

“…Lumbar puncture (LP) has become increasingly common for people with Huntington’s disease (HD) both to administer intrathecal investigational medicinal products…”
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Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington’s disease by Ou, Zhen-Yi Andy, Byrne, Lauren M., Rodrigues, Filipe B., Tortelli, Rosanna, Johnson, Eileanoir B., Foiani, Martha S., Arridge, Marzena, De Vita, Enrico, Scahill, Rachael I., Heslegrave, Amanda, Zetterberg, Henrik, Wild, Edward J.

“…Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. BDNF function is reduced in Huntington’s disease (HD), possibly…”
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Cerebellar abnormalities in Huntington's disease: A role in motor and psychiatric impairment? by Rees, Elin M., Farmer, Ruth, Cole, James H., Haider, Salman, Durr, Alexandra, Landwehrmeyer, Bernhard, Scahill, Rachael I., Tabrizi, Sarah J., Hobbs, Nicola Z.

“…The cerebellum has received limited attention in Huntington's disease (HD), despite signs of possible cerebellar dysfunction, including motor incoordination…”
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The impact of occipital lobe cortical thickness on cognitive task performance: An investigation in Huntington's Disease by Johnson, Eileanoir B., Rees, Elin M., Labuschagne, Izelle, Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A.C., Reilmann, Ralf, Johnson, Hans, Hobbs, Nicola Z., Langbehn, Douglas R., Stout, Julie C., Tabrizi, Sarah J., Scahill, Rachael I.

“…The occipital lobe is an important visual processing region of the brain. Following consistent findings of early neural changes in the occipital lobe in…”
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Timing of selective basal ganglia white matter loss in premanifest Huntington’s disease by Zeun, Paul, McColgan, Peter, Dhollander, Thijs, Gregory, Sarah, Johnson, Eileanoir B., Papoutsi, Marina, Nair, Akshay, Scahill, Rachael I., Rees, Geraint, Tabrizi, Sarah J.

“…•Limbic and caudal motor cortico-striatal tracts appear to be selectively vulnerable to degeneration in the early premanifest Huntington’s disease (preHD),…”
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Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study by Klöppel, Stefan, Gregory, Sarah, Scheller, Elisa, Minkova, Lora, Razi, Adeel, Durr, Alexandra, Roos, Raymund A.C., Leavitt, Blair R., Papoutsi, Marina, Landwehrmeyer, G. Bernhard, Reilmann, Ralf, Borowsky, Beth, Johnson, Hans, Mills, James A., Owen, Gail, Stout, Julie, Scahill, Rachael I., Long, Jeffrey D., Rees, Geraint, Tabrizi, Sarah J.

“…Cognitive and motor task performance in premanifest Huntington's disease (HD) gene-carriers is often within normal ranges prior to clinical diagnosis, despite…”
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Quantification of huntingtin protein species in Huntington's disease patient leukocytes using optimised electrochemiluminescence immunoassays by Hensman Moss, Davina J, Robertson, Nicola, Farmer, Ruth, Scahill, Rachael I, Haider, Salman, Tessari, Michela A, Flynn, Geraldine, Fischer, David F, Wild, Edward J, Macdonald, Douglas, Tabrizi, Sarah J

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT)…”
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