Search Results - "Scahill, RI"

Biological and clinical manifestations of Huntington’s disease in gene carriers very far from predicted onset by Zeun, P, Scahill, RI, Osborne-Crowley, K, Johnson, EB, Gregory, S, Parker, C, Lowe, J, Sampaio, C, Zhang, H

“…IntroductionCrucial to the future success of treatments in Huntington’s disease is identifying a timepoint where there is a measurable biomarker of early…”
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A15 MRI brain imaging as a potential marker for Huntington's disease by Scahill, RI

“…As disease-modifying treatment trials for HD become a realistic possibility, there is an urgent need to establish robust markers of disease progression with…”
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Mapping the Evolution of Regional Atrophy in Alzheimer's Disease: Unbiased Analysis of Fluid-Registered Serial MRI by Scahill, Rachael I., Schott, Jonathan M., Stevens, John M., Rossor, Martin N., Fox, Nick C.

“…Alzheimer's disease (AD) is characterized by progressive cerebral atrophy, which may be assessed by using volumetric MRI. We describe a voxel-based analysis of…”
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Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias by Good, Catriona D., Scahill, Rachael I., Fox, Nick C., Ashburner, John, Friston, Karl J., Chan, Dennis, Crum, William R., Rossor, Martin N., Frackowiak, Richard S.J.

“…We compared voxel-based morphometry (VBM) with independent accurate region-of-interest (ROI) measurements of temporal lobe structures in order to validate the…”
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A comparison of methods for the automated calculation of volumes and atrophy rates in the hippocampus by Barnes, J., Foster, J., Boyes, R.G., Pepple, T., Moore, E.K., Schott, J.M., Frost, C., Scahill, R.I., Fox, N.C.

“…Hippocampal atrophy rates have been used in a number of studies in Alzheimer’s disease (AD) to assess disease progression and are being increasingly utilized…”
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Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images by Fox, Nick C, Crum, William R, Scahill, Rachael I, Stevens, John M, Janssen, John C, Rossor, Martin N

“…Early diagnosis and monitoring of the progression of Alzheimer's disease is important for the development of therapeutic strategies. To detect the earliest…”
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Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease by Chan, Dennis, Fox, Nick C., Scahill, Rachael I., Crum, William R., Whitwell, Jennifer L., Leschziner, Guy, Rossor, Alex M., Stevens, John M., Cipolotti, Lisa, Rossor, Martin N.

“…Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to quantify the global and temporal lobe atrophy in semantic dementia and…”
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Assessing the onset of structural change in familial Alzheimer's disease by Schott, Jonathan M., Fox, Nick C., Frost, Chris, Scahill, Rachael I., Janssen, John C., Chan, Dennis, Jenkins, Rhian, Rossor, Martin N.

“…Regional and global cerebral atrophy are inevitable features of Alzheimer's disease (AD). We assessed volumes and atrophy rates of brain structures in patients…”
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Rates of global and regional cerebral atrophy in AD and frontotemporal dementia by CHAN, D, FOX, N. C, JENKINS, R, SCAHILL, R. I, CRUM, W. R, ROSSOR, M. N

“…Serial registered MRI provides a reproducible technique for detecting progressive cerebral atrophy in vivo and was used to determine if there were differences…”
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Correlation between rates of brain atrophy and cognitive decline in AD by FOX, N. C, SCAHILL, R. I, CRUM, W. R, ROSSOR, M. N

“…Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals…”
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OCULOMOTOR DEFICITS IN PREMANIFEST AND EARLY HUNTINGTON'S DISEASE AND THEIR STRUCTURAL BRAIN CORRELATES: THE LONGITUDINAL TRACK-HD STUDY by Hicks, S, Scahill, RI, Dumas, E, Durr, A, Blair, R, Levitt, BR, Roos, RAC, Tabrizi, SJ, Kennard, C

“…Background Oculomotor deficits are a potential predictor of Huntington's Disease (HD). Saccadic abnormalities include delayed initiation, low velocity and a…”
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Differentiating AD from aging using semiautomated measurement of hippocampal atrophy rates by Barnes, Josephine, Scahill, Rachael I., Boyes, Richard G., Frost, Chris, Lewis, Emma B., Rossor, Charlotte L., Rossor, Martin N., Fox, Nick C.

“…Manual segmentation of the hippocampus is the gold standard in volumetric hippocampal magnetic resonance imaging (MRI) analysis; however, this is difficult to…”
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J09 Cognitive functions of the putamen in Huntington's disease by Rees, EM, Hobbs, NZ, Farmer, RE, Henley, SMD, Haider, S, Scahill, RI, Tabrizi, SJ

“…BackgroundPutamen atrophy is widely assumed to be associated with several motor symptoms of HD but less so cognitive impairment. This study specifically…”
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G07 Reliability of diffusion tensor imaging measures by Cole, J, Rees, EM, Farmer, RE, Crawford, HE, Mueller, H-P, Sprengelmeyer, R, Frost, C, Durr, A, Landwehrmeyer, B, Tabrizi, SJ, Scahill, RI, Hobbs, NZ

“…BackgroundHuntington's disease (HD) has been associated with white matter (WM) abnormalities, evident using diffusion tensor imaging (DTI) analysis. However,…”
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G01 Evaluation of multi-modal, multi-site imaging measures in Huntington's disease: baseline results from the PADDINGTON study by Hobbs, NZ, Cole, J, Farmer, RE, Rees, EM, Scahill, RI, Crawford, HE, Roos, RAC, Sprengelmeyer, R, Durr, A, Landwehrmeyer, B, Tabrizi, SJ, Frost, C

“…BackgroundMacro- and micro-structural brain changes are of interest as markers of Huntington's Disease (HD) progression, which may prove useful in future…”
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Automated Hippocampal Segmentation by Regional Fluid Registration of Serial MRI: Validation and Application in Alzheimer's Disease by Crum, William R., Scahill, Rachael I., Fox, Nick C.

“…The application of voxel-level three-dimensional registration to serial magnetic resonance imaging (MRI) is described. This fluid registration determines…”
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G03 Corpus callosal atrophy in Huntington's disease by Crawford, HE, Hobbs, NZ, Cole, J, Rees, EM, Owen, G, Langbehn, DR, Frost, C, Landwehrmeyer, B, Reilmann, R, Craufurd, D, Stout, JC, Durr, A, Leavitt, B, Roos, RA, Tabrizi, SJ, Scahill, RI

“…BackgroundResearch into Huntington's disease (HD) has revealed white-matter loss in individuals more than 10 years prior to predicted disease onset, focused…”
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Does Alzheimer's disease affect hippocampal asymmetry? Evidence from a cross-sectional and longitudinal volumetric MRI study by Barnes, Josephine, Scahill, Rachael I, Schott, Jonathan M, Frost, Chris, Rossor, Martin N, Fox, Nick C

“…To determine whether Alzheimer's disease (AD) is associated with preferential atrophy of either the left or right hippocampus. We examined right-left asymmetry…”
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Improved reliability of hippocampal atrophy rate measurement in mild cognitive impairment using fluid registration by van de Pol, L.A., Barnes, J., Scahill, R.I., Frost, C., Lewis, E.B., Boyes, R.G., van Schijndel, R.A., Scheltens, P., Fox, N.C., Barkhof, F.

“…MRI-derived rates of hippocampal atrophy may serve as surrogate markers of disease progression in mild cognitive impairment (MCI). Manual delineation is the…”
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A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging by Scahill, Rachael I, Frost, Chris, Jenkins, Rhian, Whitwell, Jennifer L, Rossor, Martin N, Fox, Nick C

“…To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and…”
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