Search Results - "Scaglione, Giovanni"

Homologous Recombination Deficiency (HRD) Scoring, by Means of Two Different Shallow Whole-Genome Sequencing Pipelines (sWGS), in Ovarian Cancer Patients: A Comparison with Myriad MyChoice Assay by Scaglione, Giovanni L, Pignata, Sandro, Pettinato, Angela, Paolillo, Carmela, Califano, Daniela, Scandurra, Giuseppa, Lombardo, Valentina, Di Gaudio, Francesca, Pecorino, Basilio, Mereu, Liliana, Scollo, Paolo, Capoluongo, Ettore D

“…High-grade serous ovarian cancer (HGSOC) patients carrying the mutation or deficient in the homologous recombination repair system (HRD) generally benefit from…”
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One-step NGS molecular analysis of the CFTR gene on newborn dried blood spots gives a higher diagnostic sensitivity in affected and carrier subjects: A pilot study by Nunziato, Marcella, Starnone, Flavio, Giordano, Sonia, D'Antonio, Marcella, Scognamiglio, Domenico, Esposito, Maria Valeria, Correra, Antonio, Di Maggio, Federica, D'Argenio, Valeria, Scaglione, Giovanni Luca, Castaldo, Giuseppe, Salvatore, Francesco

“…Cystic fibrosis is the most common hereditary recessive disease with an incidence of about 1:2500/3000. It has long been known that the disease is caused by…”
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A Whole Germline BRCA2 Gene Deletion: How to Learn from CNV In Silico Analysis by Scaglione, Giovanni Luca, Concolino, Paola, De Bonis, Maria, De Paolis, Elisa, Minucci, Angelo, Ferrandina, Gabriella, Scambia, Giovanni, Capoluongo, Ettore

“…screening in Hereditary Breast and Ovarian Syndrome (HBOC) is an essential step for effective patients' management. Next-Generation Sequencing (NGS) can…”
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Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study by Colaneri, Marta, Fama, Federico, Fassio, Federico, Holmes, Darcy, Scaglione, Giovanni, Mariani, Chiara, Galli, Lucia, Lai, Alessia, Antinori, Spinello, Gori, Andrea, Riva, Agostino, Schiavini, Monica

“…•Early treatments against COVID-19 reduce the time to negative test results.•Early treatments against COVID-19 reduce the risk of disease progression.•COPD…”
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Understanding the burden of antibiotic resistance: a decade of carbapenem-resistant Gram-negative bacterial infections in Italian intensive care units by Scaglione, Giovanni, Perego, Matilde, Colaneri, Marta, Genovese, Camilla, Brivio, Fabio, Covizzi, Alice, Viaggi, Bruno, Bandera, Alessandra, Gori, Andrea, Finazzi, Stefano, Palomba, Emanuele

“…In patients admitted to intensive care units (ICUs), Gram-negative bacteria (GNB) infections pose significant challenges due to their contribution to…”
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Nucleophosmin C-terminal Leukemia-associated Domain Interacts with G-rich Quadruplex Forming DNA by Federici, Luca, Arcovito, Alessandro, Scaglione, Giovanni L., Scaloni, Flavio, Lo Sterzo, Carlo, Di Matteo, Adele, Falini, Brunangelo, Giardina, Bruno, Brunori, Maurizio

“…Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling phosphoprotein, mainly localized at nucleoli, that plays a key role in ribogenesis, centrosome…”
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Early administration of nirmatrelvir/ritonavir leads to faster negative SARS-CoV-2 nasal swabs than monoclonal antibodies in COVID 19 patients at high-risk for severe disease by Colaneri, Marta, Scaglione, Giovanni, Fassio, Federico, Galli, Lucia, Lai, Alessia, Bergna, Annalisa, Gabrieli, Arianna, Tarkowski, Maciej, Ventura, Carla Della, Colombo, Valeria, Cordier, Laura, Bernasconi, Davide, Corbellino, Mario, Dedivitiis, Gianfranco, Borghetti, Silvia, Visigalli, Debora, Sollima, Salvatore, Casalini, Giacomo, Rizzardini, Giuliano, Gori, Andrea, Antinori, Spinello, Riva, Agostino, Schiavini, Monica

“…Besides the well-established efficacy in preventing severe COVID-19, the impact of early treatments, namely antivirals and monoclonal antibodies (mAbs), on the…”
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Epidemiology and Clinical Insights of Catheter-Related Candidemia in Non-ICU Patients with Vascular Access Devices by Scaglione, Giovanni, Colaneri, Marta, Offer, Martina, Galli, Lucia, Borgonovo, Fabio, Genovese, Camilla, Fattore, Rebecca, Schiavini, Monica, Taino, Alba, Calloni, Maria, Casella, Francesco, Gidaro, Antonio, Fassio, Federico, Breschi, Valentina, Leoni, Jessica, Cogliati, Chiara, Gori, Andrea, Foschi, Antonella

“…Vascular access devices (VADs), namely peripheral VADs (PVADs) and central venous VADs (CVADs), are crucial in both intensive care unit (ICU) and non-ICU…”
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Nasopharyngeal Microbiome Signature in COVID-19 Positive Patients: Can We Definitively Get a Role to Fusobacterium periodonticum ? by Nardelli, Carmela, Gentile, Ivan, Setaro, Mario, Di Domenico, Carmela, Pinchera, Biagio, Buonomo, Antonio Riccardo, Zappulo, Emanuela, Scotto, Riccardo, Scaglione, Giovanni Luca, Castaldo, Giuseppe, Capoluongo, Ettore

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the pandemic Coronavirus Disease 2019 (COVID-19). This virus is highly transmissible among…”
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The healing process of diabetic ulcers correlates with changes in the cutaneous microbiota by Bruni, Emanuele, Scaglione, Giovanni Luca, Tampone, Denise, Primerano, Alessia, Bartolini, Barbara, Tenoglio, Carlo Alessio, Di Campli, Cristiana, Collina, Maria Chiara, Odorisio, Teresa, Failla, Cristina Maria

“…Skin microbiota plays an essential role in the development and function of the cutaneous immune system, in the maintenance of the skin barrier through the…”
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Enhanced NAMPT-Mediated NAD Salvage Pathway Contributes to Psoriasis Pathogenesis by Amplifying Epithelial Auto-Inflammatory Circuits by Mercurio, Laura, Morelli, Martina, Scarponi, Claudia, Scaglione, Giovanni Luca, Pallotta, Sabatino, Avitabile, Daniele, Albanesi, Cristina, Madonna, Stefania

“…Dysregulated cross-talk between immune cells and epithelial compartments is responsible for the onset and amplification of pathogenic auto-inflammatory…”
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Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA by Chiarella, Sara, De Cola, Antonella, Scaglione, Giovanni Luca, Carletti, Erminia, Graziano, Vincenzo, Barcaroli, Daniela, Lo Sterzo, Carlo, Di Matteo, Adele, Di Ilio, Carmine, Falini, Brunangelo, Arcovito, Alessandro, De Laurenzi, Vincenzo, Federici, Luca

“…Nucleophosmin (NPM1) is an abundant nucleolar protein implicated in ribosome maturation and export, centrosome duplication and response to stress stimuli. NPM1…”
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Identification of immunological patterns characterizing immune-related psoriasis reactions in oncological patients in therapy with anti-PD-1 checkpoint inhibitors by Morelli, Martina, Carbone, Maria Luigia, Scaglione, Giovanni Luca, Scarponi, Claudia, Di Francesco, Valentina, Pallotta, Sabatino, De Galitiis, Federica, Rahimi, Siavash, Madonna, Stefania, Failla, Cristina Maria, Albanesi, Cristina

“…Immunotherapy with biologics targeting programmed cell death protein-1 (PD-1) is highly effective in the treatment of various malignancies. Nevertheless, it is…”
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COVID-19 Vaccine: A Potential Risk Factor for Accelerating the Onset of Bullous Pemphigoid by Pira, Anna, Mariotti, Feliciana, Moro, Francesco, Didona, Biagio, Scaglione, Giovanni Luca, Panebianco, Annarita, Abeni, Damiano, Di Zenzo, Giovanni

“…Bullous pemphigoid (BP) is the most common autoimmune bullous disease, whose main autoantigens are hemidesmosomal components BP180 and BP230. Although recent…”
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Allelic Variants of HLA-C Upstream Region, PSORS1C3, MICA, TNFA and Genes Involved in Epidermal Homeostasis and Barrier Function Influence the Clinical Response to Anti-IL-12/IL-23 Treatment of Patients with Psoriasis by Morelli, Martina, Galluzzo, Marco, Scarponi, Claudia, Madonna, Stefania, Scaglione, Giovanni Luca, Girolomoni, Giampiero, Talamonti, Marina, Bianchi, Luca, Albanesi, Cristina

“…Several biologic therapies have been developed to treat moderate-to-severe psoriasis, with patients exhibiting different clinical benefits, possibly due to the…”
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PI3Kδ Sustains Keratinocyte Hyperproliferation and Epithelial Inflammation: Implications for a Topically Druggable Target in Psoriasis by Mercurio, Laura, Morelli, Martina, Scarponi, Claudia, Scaglione, Giovanni Luca, Pallotta, Sabatino, Albanesi, Cristina, Madonna, Stefania

“…The phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is aberrantly activated in psoriatic lesions and contributes to disease pathogenesis…”
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Paradoxical psoriasis induced by TNF‐α blockade shows immunological features typical of the early phase of psoriasis development by Fania, Luca, Morelli, Martina, Scarponi, Claudia, Mercurio, Laura, Scopelliti, Fernanda, Cattani, Caterina, Scaglione, Giovanni Luca, Tonanzi, Tiziano, Pilla, Maria Antonietta, Pagnanelli, Gianluca, Mazzanti, Cinzia, Girolomoni, Giampiero, Cavani, Andrea, Madonna, Stefania, Albanesi, Cristina

“…Immunomodulation with anti‐TNF‐α is highly effective in the treatment of various immune‐mediated inflammatory diseases, including hidradenitis suppurativa…”
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Case Report: Detection of a Novel Germline PALB2 Deletion in a Young Woman With Hereditary Breast Cancer: When the Patient's Phenotype History Doesn't Lie by De Angelis, Carmine, Nardelli, Carmela, Concolino, Paola, Pagliuca, Martina, Setaro, Mario, De Paolis, Elisa, De Placido, Pietro, Forestieri, Valeria, Scaglione, Giovanni Luca, Ranieri, Annalisa, Lombardo, Barbara, Pastore, Lucio, De Placido, Sabino, Capoluongo, Ettore

“…The partner and localizer of ( ) is a major binding partner that participates in homologous recombination repair in response to DNA double-strand breaks…”
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The performance of multi-gene panels for breast/ovarian cancer predisposition by Nunziato, Marcella, Scaglione, Giovanni Luca, Di Maggio, Federica, Nardelli, Carmela, Capoluongo, Ettore, Salvatore, Francesco

“…•Evaluation of performances of two different multi-gene panels methodologies.•Identification of genetic variants that may predispose to breast and/or ovarian…”
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CYP24A1 and SLC34A1 genetic defects associated with idiopathic infantile hypercalcemia: from genotype to phenotype by De Paolis, Elisa, Scaglione, Giovanni Luca, De Bonis, Maria, Minucci, Angelo, Capoluongo, Ettore

“…Loss of function mutations in the CYP24A1 gene, involved in vitamin D catabolism and in calcium homeostasis, are known to be the genetic drivers of both…”
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