Search Results - "Scadden, D."

Hematopoietic Stem Cell and Its Bone Marrow Niche by Yu, V W C, Scadden, D T

“…Stem cells do not thrive without their niche. The bone marrow microenvironment is where hematopoietic stem cells maintain their cell state while receiving…”
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Osteoblastic cells regulate the haematopoietic stem cell niche by Scadden, D. T, Calvi, L. M, Adams, G. B, Weibrecht, K. W, Weber, J. M, Olson, D. P, Knight, M. C, Martin, R. P, Schipani, E, Divieti, P, Bringhurst, F. R, Milner, L. A, Kronenberg, H. M

“…Stem cell fate is influenced by specialized microenvironments that remain poorly defined in mammals. To explore the possibility that haematopoietic stem cells…”
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Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis by Scadden, A D J, Vitali, Patrice

“…Adenosine deaminases acting on RNA (ADARs) catalyze hyper-editing of long dsRNAs, converting up to 50% of adenosines to inosine, to form IU-dsRNAs. Now…”
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A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function by Vallet, S, Pozzi, S, Patel, K, Vaghela, N, Fulciniti, M T, Veiby, P, Hideshima, T, Santo, L, Cirstea, D, Scadden, D T, Anderson, K C, Raje, N

“…Upregulation of cytokines and chemokines is a frequent finding in multiple myeloma (MM). CCL3 (also known as MIP-1α) is a pro-inflammatory chemokine, levels of…”
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Niche initiated oncogenesis (ECTS Excellence in Research Lecture) by Scadden, D

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Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells by Weissleder, Ralph, Lewin, Maïté, Carlesso, Nadia, Tung, Ching-Hsuan, Tang, Xiao-Wu, Cory, David, Scadden, David T

“…The ability to track the distribution and differentiation of progenitor and stem cells by high-resolution in vivo imaging techniques would have significant…”
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Stem cell repopulation efficiency but not pool size is governed by p27(kip1) by Cheng, T, Rodrigues, N, Dombkowski, D, Stier, S, Scadden, D T

“…Sustained blood cell production requires preservation of a quiescent, multipotential stem cell pool that intermittently gives rise to progenitors with robust…”
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A niche opportunity for stem cell therapeutics by Adams, G B, Scadden, D T

“…The success of hematopoietic stem cell (HSC)-based therapies relies on the ability of the stem cells to both engraft and self-renew sufficiently in the bone…”
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A hostel for the hostile: the bone marrow niche in hematologic neoplasms by Krause, Daniela S, Scadden, David T

“…Our understanding of the biology of the normal hematopoietic stem cell niche has increased steadily due to improved murine models and sophisticated imaging…”
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OP 6.4 – 00096 High-efficiency CRISPR/Cas9-mediated disruption of ccr5 in human hematopoietic stem progenitor cells generates HIV-refractory immune systems by D. Claiborne, Z. Detwiler, K. Okawa, T. Bateson, T. Chen, D. Scadden, C. Boutwell, T. Allen

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Regulation of hematopoietic stem cell growth by ATTAR, E. C, SCADDEN, D. T

“…Hematopoietic stem cells (HSC) must balance self-renewal and differentiation to provide sufficient primitive cells to sustain hematopoiesis, while generating…”
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Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma by Raje, N, Hideshima, T, Mukherjee, S, Raab, M, Vallet, S, Chhetri, S, Cirstea, D, Pozzi, S, Mitsiades, C, Rooney, M, Kiziltepe, T, Podar, K, Okawa, Y, Ikeda, H, Carrasco, R, Richardson, P G, Chauhan, D, Munshi, N C, Sharma, S, Parikh, H, Chabner, B, Scadden, D, Anderson, K C

“…Cyclin D dysregulation and overexpression is noted in the majority of multiple myeloma (MM) patients, suggesting its critical role in MM pathogenesis. Here, we…”
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Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma by Gill, P S, Wernz, J, Scadden, D T, Cohen, P, Mukwaya, G M, von Roenn, J H, Jacobs, M, Kempin, S, Silverberg, I, Gonzales, G, Rarick, M U, Myers, A M, Shepherd, F, Sawka, C, Pike, M C, Ross, M E

“…To compare the safety and efficacy of liposomal daunorubicin (DaunoXome; NeXstar Pharmaceuticals, Inc, Boulder, CO) with a reference regimen of doxorubicin,…”
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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer by Willett, Christopher G, Jain, Rakesh K, Boucher, Yves, di Tomaso, Emmanuelle, Duda, Dan G, Munn, Lance L, Tong, Ricky T, Chung, Daniel C, Sahani, Dushyant V, Kalva, Sanjeeva P, Kozin, Sergey V, Mino, Mari, Cohen, Kenneth S, Scadden, David T, Hartford, Alan C, Fischman, Alan J, Clark, Jeffrey W, Ryan, David P, Zhu, Andrew X, Blaszkowsky, Lawrence S, Chen, Helen X, Shellito, Paul C, Lauwers, Gregory Y

“…The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single…”
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Chemotherapy for Human Immunodeficiency Virus–Associated Non-Hodgkin’s Lymphoma in Combination With Highly Active Antiretroviral Therapy by RATNER, Lee, LEE, Jeannette, HARRINGTON, William, GROCHOW, Louise, FLEXNER, Charles, TAN, Benjamin, STRAUSS, David, SHENGHUI TANG, REDDEN, David, HAMZEH, Fayez, HERNDIER, Brian, SCADDEN, David, KAPLAN, Lawrence, AMBINDER, Richard, LEVINE, Alexandra

“…This study investigated the efficacy, toxicity, and pharmacokinetic interactions resulting from simultaneous combination chemotherapy and highly active…”
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Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo by Jain, Rakesh K, Stroh, Mark, Zimmer, John P, Duda, Dan G, Levchenko, Tatyana S, Cohen, Kenneth S, Brown, Edward B, Scadden, David T, Torchilin, Vladimir P, Bawendi, Moungi G, Fukumura, Dai

“…A solid tumor is an organ composed of cancer and host cells embedded in an extracellular matrix and nourished by blood vessels. A prerequisite to understanding…”
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CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells by Shen, Hongmei, Cheng, Tao, Olszak, Ivona, Garcia-Zepeda, Eduardo, Lu, Zhijian, Herrmann, Steven, Fallon, Robert, Luster, Andrew D, Scadden, David T

“…The chemokine stroma-derived factor (SDF)-1, and its receptor, CXCR-4, have been shown to be essential for the translocation of hemopoietic stem cells from the…”
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Lipid availability determines fate of skeletal progenitor cells via SOX9 by van Gastel, Nick, Stegen, Steve, Eelen, Guy, Schoors, Sandra, Carlier, Aurélie, Daniëls, Veerle W., Baryawno, Ninib, Przybylski, Dariusz, Depypere, Maarten, Stiers, Pieter-Jan, Lambrechts, Dennis, Van Looveren, Riet, Torrekens, Sophie, Sharda, Azeem, Agostinis, Patrizia, Lambrechts, Diether, Maes, Frederik, Swinnen, Johan V., Geris, Liesbet, Van Oosterwyck, Hans, Thienpont, Bernard, Carmeliet, Peter, Scadden, David T., Carmeliet, Geert

“…The avascular nature of cartilage makes it a unique tissue 1 – 4 , but whether and how the absence of nutrient supply regulates chondrogenesis remain unknown…”
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The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity by Kook, S H, Cho, J S, Morrison, A, Wiener, E, Lee, S B, Scadden, D, Lee, B-C

“…In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences…”
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The PTB interacting protein raver1 regulates α-tropomyosin alternative splicing by Gromak, Natalia, Rideau, Alexis, Southby, Justine, Scadden, A. D. J., Gooding, Clare, Hüttelmaier, Stefan, Singer, Robert H., Smith, Christopher W. J.

“…Regulated switching of the mutually exclusive exons 2 and 3 of α‐tropomyosin (TM) involves repression of exon 3 in smooth muscle cells. Polypyrimidine…”
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