Search Results - "Sbroggiò, Mauro"

Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality by Albers, Eliene, Sbroggiò, Mauro, Pladevall-Morera, David, Bizard, Anna H., Avram, Alexandra, Gonzalez, Patricia, Martin-Gonzalez, Javier, Hickson, Ian D., Lopez-Contreras, Andres J.

“…PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report…”
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An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress by Sorge, Matteo, Savoré, Giulia, Gallo, Andrea, Acquarone, Davide, Sbroggiò, Mauro, Velasco, Silvia, Zamporlini, Federica, Femminò, Saveria, Moiso, Enrico, Morciano, Giampaolo, Balmas, Elisa, Raimondi, Andrea, Nattenberg, Gabrielle, Stefania, Rachele, Tacchetti, Carlo, Rizzo, Angela Maria, Corsetto, Paola, Ghigo, Alessandra, Turco, Emilia, Altruda, Fiorella, Silengo, Lorenzo, Pinton, Paolo, Raffaelli, Nadia, Sniadecki, Nathan J, Penna, Claudia, Pagliaro, Pasquale, Hirsch, Emilio, Riganti, Chiara, Tarone, Guido, Bertero, Alessandro, Brancaccio, Mara

“…Defining the molecular mechanisms underlying cardiac resilience is crucial to find effective approaches to protect the heart. A physiologic level of ROS is…”
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Key role of ERK1/2 molecular scaffolds in heart pathology by Tarone, Guido, Sbroggiò, Mauro, Brancaccio, Mara

“…The ability of cardiomyocytes to detect mechanical and humoral stimuli is critical for adaptation of the myocardium in response to new conditions and for…”
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ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1 by Sbroggiò, Mauro, Bertero, Alessandro, Velasco, Silvia, Fusella, Federica, De Blasio, Emanuele, Bahou, Wadie F, Silengo, Lorenzo, Turco, Emilia, Brancaccio, Mara, Tarone, Guido

“…Extracellular signal-regulated kinase 1/2 (ERK1/2) signalling is a key pathway in cardiomyocyte hypertrophy and survival in response to many different stress…”
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IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload by Sbroggiò, Mauro, Carnevale, Daniela, Bertero, Alessandro, Cifelli, Giuseppe, De Blasio, Emanuele, Mascio, Giada, Hirsch, Emilio, Bahou, Wadie F., Turco, Emilia, Silengo, Lorenzo, Brancaccio, Mara, Lembo, Giuseppe, Tarone, Guido

“…Aims The Raf-MEK1/2-ERK1/2 (ERK1/2-extracellular signal-regulated kinases 1/2) signalling cascade is crucial in triggering cardiac responses to different…”
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Placental Growth Factor Regulates Cardiac Inflammation Through the Tissue Inhibitor of Metalloproteinases-3/Tumor Necrosis Factor-α―Converting Enzyme Axis: Crucial Role for Adaptive Cardiac Remodeling During Cardiac Pressure Overload by CARNEVALE, Daniela, CIFELLI, Giuseppe, MASCIO, Giada, MADONNA, Michele, SBROGGIO, Mauro, PERRINO, Cinzia, GRAZIA PERSICO, Maria, FRATI, Giacomo, LEMBO, Giuseppe

“…Heart failure is one of the leading causes of mortality and is primarily the final stage of several overload cardiomyopathies, preceded by an early adaptive…”
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Morgana and melusin: Two fairies chaperoning signal transduction by Ferretti, Roberta, Sbroggiò, Mauro, Di Savino, Augusta, Fusella, Federica, Bertero, Alessandro, Michowski, Wojciech, Tarone, Guido, Brancaccio, Mara

“…Chaperones and scaffold proteins are key elements involved in controlling the assembly of molecular complexes required for coordinated signal transduction…”
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A simple DNA recombination screening method by RT-PCR as an alternative to Southern blot by Albers, Eliene, Sbroggiò, Mauro, Martin-Gonzalez, Javier, Avram, Alexandra, Munk, Stephanie, Lopez-Contreras, Andres J.

“…The generation of genetically engineered mouse models (GEMMs), including knock-out (KO) and knock-in (KI) models, often requires genomic screening of many…”
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Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure by Waardenberg, Ashley J., Bernardo, Bianca C., Ng, Dominic C.H., Shepherd, Peter R., Cemerlang, Nelly, Sbroggiò, Mauro, Wells, Christine A., Dalrymple, Brian P., Brancaccio, Mara, Lin, Ruby C.Y., McMullen, Julie R.

“…Maintenance of cardiac structure and Z-disc signaling are key factors responsible for protecting the heart in a setting of stress, but how these processes are…”
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The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1 by Sbroggiò, Mauro, Ferretti, Roberta, Percivalle, Elena, Gutkowska, Malgorzata, Zylicz, Alicja, Michowski, Wojciech, Kuznicki, Jacek, Accornero, Federica, Pacchioni, Beniamina, Lanfranchi, Gerolamo, Hamm, Jorg, Turco, Emilia, Silengo, Lorenzo, Tarone, Guido, Brancaccio, Mara

“…Melusin is a mammalian muscle specific CHORD containing protein capable of activating signal transduction pathways leading to cardiomyocytes hypertrophy in…”
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Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis by Patrucco, Enrico, Domes, Katrin, Sbroggió, Mauro, Blaich, Anne, Schlossmann, Jens, Desch, Matthias, Rybalkin, Sergei D, Beavo, Joseph A, Lukowski, Robert, Hofmann, Franz

“…Conflicting results have been reported for the roles of cGMP and cGMP-dependent protein kinase I (cGKI) in various pathological conditions leading to cardiac…”
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Morgana/chp-1, a ROCK Inhibitor Involved in Centrosome Duplication and Tumorigenesis by Ferretti, Roberta, Palumbo, Valeria, Di Savino, Augusta, Velasco, Silvia, Sbroggiò, Mauro, Sportoletti, Paolo, Micale, Lucia, Turco, Emilia, Silengo, Lorenzo, Palumbo, Gioacchino, Hirsch, Emilio, Teruya-Feldstein, Julie, Bonaccorsi, Silvia, Pandolfi, Pier Paolo, Gatti, Maurizio, Tarone, Guido, Brancaccio, Mara

“…Centrosome abnormalities lead to genomic instability and are a common feature of many cancer cells. Here we show that mutations in morgana/chp-1 result in…”
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Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis by MacGrogan, Donal, D’Amato, Gaetano, Travisano, Stanislao, Martinez-Poveda, Beatriz, Luxán, Guillermo, del Monte-Nieto, Gonzalo, Papoutsi, Tania, Sbroggio, Mauro, Bou, Vanesa, Gomez-del Arco, Pablo, Gómez, Manuel Jose, Zhou, Bin, Redondo, Juan Miguel, Jiménez-Borreguero, Luis J, de la Pompa, José Luis

“…RATIONALE:The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial–mesenchymal transition, and NOTCH1 mutations cause…”
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PICH deficiency limits the progression of MYC-induced B-cell lymphoma by Castejón-Griñán, María, Albers, Eliene, Simón-Carrasco, Lucía, Aguilera, Paula, Sbroggio, Mauro, Pladevall-Morera, David, Ingham, Andreas, Lim, Ernest, Guillen-Benitez, Alba, Pietrini, Elena, Lisby, Michael, Hickson, Ian D., Lopez-Contreras, Andres J.

“…Plk1-interacting checkpoint helicase (PICH) is a DNA translocase involved in resolving ultrafine anaphase DNA bridges and, therefore, is important to safeguard…”
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Selective Rac-1 Inhibition Protects From Diabetes-Induced Vascular Injury by Vecchione, Carmine, Aretini, Alessandra, Marino, Gennaro, Bettarini, Umberto, Poulet, Roberta, Maffei, Angelo, Sbroggiò, Mauro, Pastore, Lucio, Gentile, Maria Teresa, Notte, Antonella, Iorio, Luca, Hirsch, Emilio, Tarone, Guido, Lembo, Giuseppe

“…Diabetes mellitus is a main risk factor for vascular diseases. Vascular injury induced by diabetes mellitus is characterized by endothelial dysfunction…”
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Cardiac Overexpression of Melusin Protects From Dilated Cardiomyopathy Due to Long-Standing Pressure Overload by De Acetis, Marika, Notte, Antonella, Accornero, Federica, Selvetella, Giulio, Brancaccio, Mara, Vecchione, Carmine, Sbroggiò, Mauro, Collino, Federica, Pacchioni, Beniamina, Lanfranchi, Gerolamo, Aretini, Alessandra, Ferretti, Roberta, Maffei, Angelo, Altruda, Fiorella, Silengo, Lorenzo, Tarone, Guido, Lembo, Giuseppe

“…We have previously shown that genetic ablation of melusin, a muscle specific β 1 integrin interacting protein, accelerates left ventricle (LV) dilation and…”
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An intrinsic mechanism of metabolic resilience influences the cardiac response to stress by Sorge, Matteo, Gallo, Andrea, Rubinetto, Cristina, Sbroggiò, Mauro, Haute, Alexandra, Moiso, Enrico, Femminò, Saveria, Zamporlini, Federica, Martini, Miriam, Ghigo, Alessandra, Raffaelli, Nadia, Penna, Claudia, Pagliaro, Pasquale, Riganti, Chiara, Tarone, Guido, Brancaccio, Mara

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Melusin: A cardioprotective chaperone able to modulate lipid metabolism and ROS production in the heart by Sorge, Matteo, Gallo, Andrea, Cavallari, Eleonora, Sbroggiò, Mauro, Rubinetto, Cristina, Cimino, James, Moiso, Enrico, Haute, Alexandra, Femminò, Saveria, Raimondi, Andrea, Penna, Claudia, Pagliaro, Pasquale, Ghigo, Alessandra, Hirsch, Emilio, Tacchetti, Carlo, Digilio, Giuseppe, Riganti, Chiara, Tarone, Guido, Brancaccio, Mara

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Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction by Unsöld, Bernhard, Kaul, Axel, Sbroggiò, Mauro, Schubert, Carola, Regitz-Zagrosek, Vera, Brancaccio, Mara, Damilano, Federico, Hirsch, Emilio, Van Bilsen, Marc, Munts, Chantal, Sipido, Karin, Bito, Virginie, Detre, Elke, Wagner, Nana Maria, Schäfer, Katrin, Seidler, Tim, Vogt, Johannes, Neef, Stefan, Bleckmann, Annalen, Maier, Lars S, Balligand, Jean Luc, Bouzin, Caroline, Ventura-Clapier, Renée, Garnier, Anne, Eschenhagen, Thomas, El-Armouche, Ali, Knöll, Ralph, Tarone, Guido, Hasenfuß, Gerd

“…Melusin is a muscle-specific chaperone protein whose expression is required for a compensatory hypertrophy response to pressure overload. Here, we evaluated…”
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Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis by Nus, Meritxell, Martínez-Poveda, Beatriz, MacGrogan, Donal, Chevre, Rafael, D'Amato, Gaetano, Sbroggio, Mauro, Rodríguez, Cristina, Martínez-González, José, Andrés, Vicente, Hidalgo, Andrés, de la Pompa, José Luis

“…To determine the role of NOTCH during the arterial injury response and the subsequent chronic arterial-wall inflammation underlying atherosclerosis. We have…”
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