Search Results - "Sbisà, Elisabetta"

Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer? by Valletti, Alessio, Marzano, Flaviana, Pesole, Graziano, Sbisà, Elisabetta, Tullo, Apollonia

“…Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended…”
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Complexity and Dynamics of the Winemaking Bacterial Communities in Berries, Musts, and Wines from Apulian Grape Cultivars through Time and Space by Marzano, Marinella, Fosso, Bruno, Manzari, Caterina, Grieco, Francesco, Intranuovo, Marianna, Cozzi, Giuseppe, Mulè, Giuseppina, Scioscia, Gaetano, Valiente, Gabriel, Tullo, Apollonia, Sbisà, Elisabetta, Pesole, Graziano, Santamaria, Monica

“…Currently, there is very little information available regarding the microbiome associated with the wine production chain. Here, we used an amplicon sequencing…”
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Emerging Roles of TRIM8 in Health and Disease by Marzano, Flaviana, Guerrini, Luisa, Pesole, Graziano, Sbisà, Elisabetta, Tullo, Apollonia

“…The superfamily of TRIM (TRIpartite Motif-containing) proteins is one of the largest groups of E3 ubiquitin ligases. Among them, interest in TRIM8 has greatly…”
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Identification and functional characterization of two new transcriptional variants of the human p63 gene by Mangiulli, Marina, Valletti, Alessio, Caratozzolo, Mariano Francesco, Tullo, Apollonia, Sbisà, Elisabetta, Pesole, Graziano, D'Erchia, Anna Maria

“…p63 belongs to a family of transcription factors, which, while demonstrating striking conservation of functional domains, regulate distinct biological…”
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Whole-Exome and Transcriptome Sequencing Expands the Genotype of Majewski Osteodysplastic Primordial Dwarfism Type II by Marzano, Flaviana, Chiara, Matteo, Consiglio, Arianna, D'Amato, Gabriele, Gentile, Mattia, Mirabelli, Valentina, Piane, Maria, Savio, Camilla, Fabiani, Marco, D'Elia, Domenica, Sbisà, Elisabetta, Scarano, Gioacchino, Lonardo, Fortunato, Tullo, Apollonia, Pesole, Graziano, Faienza, Maria Felicia

“…Microcephalic Osteodysplastic Primordial Dwarfism type II (MOPDII) represents the most common form of primordial dwarfism. MOPD clinical features include…”
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The Underestimated Role of the p53 Pathway in Renal Cancer by Amendolare, Alessandra, Marzano, Flaviana, Petruzzella, Vittoria, Vacca, Rosa Anna, Guerrini, Luisa, Pesole, Graziano, Sbisà, Elisabetta, Tullo, Apollonia

“…The TP53 tumor suppressor gene is known as the guardian of the genome, playing a pivotal role in controlling genome integrity, and its functions are lost in…”
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Editor's Note: p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes by Lefkimmiatis, Konstantinos, Caratozzolo, Mariano Francesco, Merlo, Paola, D'Erchia, Anna Maria, Navarro, Beatriz, Levrero, Massimo, Sbisa', Elisabetta, Tullo, Apollonia

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TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours by Mastropasqua, Francesca, Marzano, Flaviana, Valletti, Alessio, Aiello, Italia, Di Tullio, Giuseppe, Morgano, Annalisa, Liuni, Sabino, Ranieri, Elena, Guerrini, Luisa, Gasparre, Giuseppe, Sbisà, Elisabetta, Pesole, Graziano, Moschetta, Antonio, Caratozzolo, Mariano Francesco, Tullo, Apollonia

“…TRIM8 plays a key role in controlling the p53 molecular switch that sustains the transcriptional activation of cell cycle arrest genes and response to…”
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Plant miRNAs Reduce Cancer Cell Proliferation by Targeting MALAT1 and NEAT1: A Beneficial Cross-Kingdom Interaction by Marzano, Flaviana, Caratozzolo, Mariano Francesco, Consiglio, Arianna, Licciulli, Flavio, Liuni, Sabino, Sbisà, Elisabetta, D’Elia, Domenica, Tullo, Apollonia, Catalano, Domenico

“…MicroRNAs (miRNAs) are ubiquitous regulators of gene expression, evolutionarily conserved in plants and mammals. In recent years, although a growing number of…”
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TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance by Marzano, Flaviana, Caratozzolo, Mariano Francesco, Pesole, Graziano, Sbisà, Elisabetta, Tullo, Apollonia

“…Colorectal cancer (CRC) represents one of the most widespread forms of cancer in the population and, as all malignant tumors, often develops resistance to…”
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Tissue-specific mtDNA abundance from exome data and its correlation with mitochondrial transcription, mass and respiratory activity by D'Erchia, Anna Maria, Atlante, Anna, Gadaleta, Gemma, Pavesi, Giulio, Chiara, Matteo, De Virgilio, Caterina, Manzari, Caterina, Mastropasqua, Francesca, Prazzoli, Gian Marco, Picardi, Ernesto, Gissi, Carmela, Horner, David, Reyes, Aurelio, Sbisà, Elisabetta, Tullo, Apollonia, Pesole, Graziano

“…Eukaryotic cells contain a population of mitochondria, variable in number and shape, which in turn contain multiple copies of a tiny compact genome (mtDNA)…”
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Connecting p63 to Cellular Proliferation: The Example of the Adenosine Deaminase Target Gene by Sbisà, Elisabetta, Mastropasqua, Giuseppe, Lefkimmiatis, Kostantinos, Caratozzolo, Mariano Francesco, D'Erchia, Anna Maria, Tullo, Apollonia

“…An unresolved issue regards the role of p73 and p63, the two homologs of the p53 oncosuppressor gene, in normal cells and in tumour development. Specific…”
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Rapha Myr ® , a Blend of Sulforaphane and Myrosinase, Exerts Antitumor and Anoikis-Sensitizing Effects on Human Astrocytoma Cells Modulating Sirtuins and DNA Methylation by Tomasello, Barbara, Di Mauro, Maria Domenica, Malfa, Giuseppe Antonio, Acquaviva, Rosaria, Sinatra, Fulvia, Spampinato, Giorgia, Laudani, Samuele, Villaggio, Giusy, Bielak-Zmijewska, Anna, Grabowska, Wioleta, Barbagallo, Ignazio Alberto, Liuzzo, Maria Teresa, Sbisà, Elisabetta, Forte, Maria Grazia, Di Giacomo, Claudia, Bonucci, Massimo, Renis, Marcella

“…Brain and other nervous system cancers are the 10th leading cause of death worldwide. Genome instability, cell cycle deregulation, epigenetic mechanisms,…”
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TRIM8: Making the Right Decision between the Oncogene and Tumour Suppressor Role by Caratozzolo, Mariano Francesco, Marzano, Flaviana, Mastropasqua, Francesca, Sbisà, Elisabetta, Tullo, Apollonia

“…The TRIM8/GERP protein is a member of the TRIM family defined by the presence of a common domain structure composed of a tripartite motif including a…”
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Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target by TULLO, Apollonia, MASTROPASQUA, Giuseppe, BOURDON, Jean Christophe, CENTONZE, Paola, GOSTISSA, Monica, COSTANZO, Antonio, LEVRERO, Massimo, DEL SAL, Giannino, SACCONE, Cecilia, SBISA, Elisabetta

“…The discovery of the p73 and p63 genes, homologous to p53 tumor suppressor has uncovered a family of transcription factors and widened the scenario of cell…”
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TRIM8 modulates p53 activity to dictate cell cycle arrest by Caratozzolo, Mariano Francesco, Micale, Lucia, Turturo, Maria Giuseppina, Cornacchia, Silvia, Fusco, Carmela, Marzano, Flaviana, Augello, Bartolomeo, D'Erchia, Anna Maria, Guerrini, Luisa, Pesole, Graziano, Sbisà, Elisabetta, Merla, Giuseppe, Tullo, Apollonia

“…p53 is a central hub in controlling cell proliferation. To maintain genome integrity in response to cellular stress, p53 directly regulates the transcription…”
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Lineage specificity of the evolutionary dynamics of the mtDNA D-loop region in rodents by Larizza, Alessandra, Pesole, Graziano, Reyes, Aurelio, Sbisà, Elisabetta, Saccone, Cecilia

“…This paper reports an intraorder study on the D-loop-containing region of the mitochondrial DNA in rodents. A complete multialignment of this region is not…”
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TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background by Caratozzolo, Mariano Francesco, Marzano, Flaviana, Abbrescia, Daniela Isabel, Mastropasqua, Francesca, Petruzzella, Vittoria, Calabrò, Viola, Pesole, Graziano, Sbisà, Elisabetta, Guerrini, Luisa, Tullo, Apollonia

“…The p53 gene family network plays a pivotal role in the control of many biological processes and therefore the right balance between the pro-apoptotic and…”
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TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma by Caratozzolo, Mariano Francesco, Valletti, Alessio, Gigante, Margherita, Aiello, Italia, Mastropasqua, Francesca, Marzano, Flaviana, Ditonno, Pasquale, Carrieri, Giuseppe, Simonnet, Hélène, D'Erchia, Anna Maria, Ranieri, Elena, Pesole, Graziano, Sbisà, Elisabetta, Tullo, Apollonia

“…In some tumours, despite a wild-type p53 gene, the p53 pathway is inactivated by alterations in its regulators or by unknown mechanisms, leading to resistance…”
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The Fatty Acid Synthase Gene is a Conserved p53 Family Target Gene from Worm to Human by D'Erchia, Anna Maria, Tullo, Apollonia, Lefkimmiatis, Konstantinos, Saccone, Cecilia, Sbisà, Elisabetta

“…The discovery that the p53 family consists of three members (p53, p63 and p73) in vertebrates and of a single homolog in invertebrates has raised the challenge…”
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