Search Results - "Sberna, Gian"

A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems by Kaminskas, Lisa M., PhD, McLeod, Victoria M., BSc, Kelly, Brian D., PhD, Sberna, Gian, PhD, Boyd, Ben J., PhD, Williamson, Mark, PhD, Owen, David J., PhD, Porter, Christopher J.H., PhD

“…Abstract The pharmacokinetics, biodistribution, and antitumor efficacy of three doxorubicin formulations (doxorubicin in saline, conjugated to a polylysine…”
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Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor Models by Kaminskas, Lisa M, McLeod, Victoria M, Kelly, Brian D, Cullinane, Carleen, Sberna, Gian, Williamson, Mark, Boyd, Ben J, Owen, David J, Porter, Christopher J. H

“…PEGylated polylysine dendrimers show promise as novel drug delivery systems with the potential to direct site specific deposition patterns and to reduce…”
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Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease by Small, David H., Michaelson, Samantha, Sberna, Gian

“…The cholinesterases are members of the serine hydrolase family, which utilizes a serine residue at the active site. Acetylcholinesterase (AChE) is…”
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A Diketopiperazine Dimer from a Marine-Derived Isolate of Aspergillus niger by OVENDEN, Simon P. B., SBERNA, Gian, TAIT, R. Murray, WILDMAN, Howard G., PATEL, Rupal, LI, Bin, STEFFY, Kevin, NGUYEN, Natalie, MEURER-GRIMES, Barbara M.

“…The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of…”
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Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease by Mok, Su San, Sberna, Gian, Heffernan, Damien, Cappai, Roberto, Galatis, Denise, Clarris, Heidi J, Sawyer, William H, Beyreuther, Konrad, Masters, Colin L, Small, David H

“…Deletion mutagenesis studies have suggested that there are two domains within APP which bind heparan sulphate. These domains have been cloned and expressed in…”
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Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer's disease by Sáez-Valero, J, Sberna, G, McLean, C A, Masters, C L, Small, D H

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Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker by Kaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Owen, David J., Boyd, Ben J., Porter, Christopher J.H.

“…Polylysine dendrimers have potential as biodegradable vectors for the delivery of cytotoxic drugs to solid tumours. Here, the cytotoxicity, drug release and…”
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The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter by Ryan, Michael T., Herd, Susanna M., Sberna, Gian, Samuel, Melanie M., Hoogenraad, Nicholas J., Høj, Peter B.

“…Chaperonins are a class of stress-inducible molecular chaperones involved in protein folding. We report the cloning, sequencing and characterisation of the rat…”
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Assessment of a novel marker of ICU strain, the ICU Activity Index, during the COVID-19 pandemic in Victoria, Australia by Pilcher, David V, Duke, Graeme, Rosenow, Melissa, Coatsworth, Nicholas, O'Neill, Genevieve, Tobias, Tracey A, McGloughlin, Steven, Holley, Anthony, Warrillow, Steven, Cattigan, Claire, Huckson, Sue, Sberna, Gian, McClure, Jason

“…To validate a real-time Intensive Care Unit (ICU) Activity Index as a marker of ICU strain from daily data available from the Critical Health Resource…”
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Capping Methotrexate α-Carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers by Kaminskas, Lisa M, Kelly, Brian D, McLeod, Victoria M, Sberna, Gian, Boyd, Ben J, Owen, David J, Porter, Christopher J. H

“…A generation 5 PEGylated (PEG 1100) polylysine dendrimer, conjugated via a stable amide linker to OtBu protected methotrexate (MTX), was previously shown to…”
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Tuberculosis Diagnostic Tests: Sensitivity, Specificity, and Comparing Apples with Apples/From the Author by Radford, Anthony J, Rothel, James S, Jones, Stephen L, Sberna, Gian, Richeldi, Luca

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Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase by Ovenden, Simon P.B., Yu, Jin, San Wan, Soo, Sberna, Gian, Murray Tait, R., Rhodes, David, Cox, Susan, Coates, Jonathan, Walsh, Neville G., Meurer-Grimes, Barbara M.

“…The cyclolignan globoidnan A, which inhibits HIV integrase, was isolated from Eucalyptus globoidea. The structure of globoidnan A was solved by 2D NMR. An HTS…”
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Molecular Isoform Distribution and Glycosylation of Acetylcholinesterase Are Altered in Brain and Cerebrospinal Fluid of Patients with Alzheimer’s Disease by Sáez‐Valero, Javier, Sberna, Gian, McLean, Catriona A., Small, David H.

“…: The glycosylation of acetylcholinesterase (AChE) in CSF was analyzed by lectin binding. AChE from Alzheimer’s disease (AD) patients was found to bind…”
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The Amyloid β‐Protein of Alzheimer's Disease Increases Acetylcholinesterase Expression by Increasing Intracellular Calcium in Embryonal Carcinoma P19 Cells by Sberna, Gian, Sáez‐Valero, Javier, Beyreuther, Konrad, Masters, Colin L., Small, David H.

“…: One of the characteristic changes that occurs in Alzheimer's disease is the loss of acetylcholinesterase (AChE) from both cholinergic and noncholinergic…”
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Tuberculosis diagnostic tests: sensitivity, specificity, and comparing apples with apples by Radford, Anthony J, Rothel, James S, Jones, Stephen L, Sberna, Gian

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Acetylcholinesterase Is Increased in the Brains of Transgenic Mice Expressing the C‐Terminal Fragment (CT100) of the β‐Amyloid Protein Precursor of Alzheimer's Disease by Sberna, Gian, Sáez‐Valero, Javier, Li, Qiao‐Xin, Czech, Christian, Beyreuther, Konrad, Masters, Colin L., McLean, Catriona A., Small, David H.

“…: Acetylcholinesterase (AChE) expression is markedly affected in Alzheimer's disease (AD). AChE activity is lower in most regions of the AD brain, but it is…”
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Physaloside A, an acylated sucrose ester from Physalis viscosa by Ovenden, S.P.B, Yu, J, Bernays, J, Wan, S.S, Christophidis, L.J, Sberna, G, Tait, R.M, Wildman, H.G, Lebeller, D, Lowther, J

“…Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The…”
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Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1 by Ovenden, Simon P B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R Murray, Wildman, Howard G, Lebeller, Dominique, Platel, Denis, May, Tom W, Meurer-Grimes, Barbara M

“…To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their…”
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A Diketopiperazine Dimer from a Marine-Derived Isolate of Aspergillus n iger by Ovenden, Simon P. B, Sberna, Gian, Tait, R. Murray, Wildman, Howard G, Patel, Rupal, Li, Bin, Steffy, Kevin, Nguyen, Natalie, Meurer-Grimes, Barbara M

“…The new diketopiperazine dimer 1, as well as the known compounds TMC-256A1 (2), TMC-256C1 (3), and demethylkotanin (4), were isolated from a culture of…”
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Physaloside A, an Acylated Sucrose Ester from Physalis v iscosa by Ovenden, Simon P. B, Yu, Jin, Bernays, Jill, Wan, Soo San, Christophidis, Larissa J, Sberna, Gian, Tait, R. Murray, Wildman, Howard G, Lebeller, Dominique, Lowther, John, Walsh, Neville G, Meurer-Grimes, Barbara M

“…Chemical investigations of the crude MeOH extract of Physalis viscosa led to the identification of the novel acylated sucrose ester physaloside A (1). The…”
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