Search Results - "Sazonovs, A"

Rare-Variant Studies to Complement Genome-Wide Association Studies by Sazonovs, A, Barrett, J.C

“…Genome-wide association studies (GWASs) have revolutionized human disease genetics by discovering tens of thousands of associations between common variants and…”
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OP11 Exploring the potential clinical utility of NUDT15 pharmacogenetic testing in clinical practice: a ‘focused reverse phenotyping’ study in the UK IBD Bioresource by Roberts, C, Sazonovs, A, Smith, R, Bishara, M, Lin, S, Neil, C, Bewshea, C, Warden, S, Pele, L, Cocking, L, Goodhand, J, Kennedy, N, Parkes, M, Ahmad, T

“…Abstract Background In a previous study we recruited patients with inflammatory bowel disease (IBD) and a history of thiopurine induced myelosuppression (TIM)…”
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P440 Prevalence of NUDT15 polymorphisms and incidence of thiopurine-induced leukopenia in Inflammatory Bowel Disease patients: A systematic review and meta-analysis by Yu, N, Sriranganathan, D, Walker, G J, Sazonovs, A, Wilding, H, Kennedy, N A, Ahmad, T, Boyapati, R K, Segal, J P, Ding, N J S

“…Abstract Background Nudix hydrolase 15 (NUDT15) genetic polymorphisms confer an increased risk of thiopurine-induced myelosuppression (TIM). Thiopurines…”
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OP013 HLA-DQA1 contributes to the development of antibodies to anti-TNF therapy in Crohn’s disease by Sazonovs, A, Kennedy, N A, Bewshea, C, Moutsianas, L, Walker, G J, De Lange, K, Goodhand, J, Anderson, C, Barrett, J, Ahmad, T

“…Abstract Background Immunogenicity to anti-TNF therapy is a major cause of loss of response, treatment discontinuation and hypersensitivity reactions and…”
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