MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

The effect of the anticonvulsant and neuroprotective agent (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) has been studied on synaptic events in the CA1 region of rat hippocampal slices. MK-801 blocked selectively the N-methyl-D-aspartate receptor-mediated compone...

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Bibliographic Details
Published in:Neuroscience letters Vol. 80; no. 1; p. 111
Main Authors: Coan, E J, Saywood, W, Collingridge, G L
Format: Journal Article
Language:English
Published: Ireland 11-09-1987
Subjects:
Animals
Dibenzocycloheptenes - pharmacology
Dizocilpine Maleate
Female
Hippocampus - drug effects
Hippocampus - physiology
In Vitro Techniques
Rats
Receptors, N-Methyl-D-Aspartate
Receptors, Neurotransmitter - physiology
Synapses - drug effects
Synapses - physiology
Synaptic Transmission - drug effects
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Summary:The effect of the anticonvulsant and neuroprotective agent (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) has been studied on synaptic events in the CA1 region of rat hippocampal slices. MK-801 blocked selectively the N-methyl-D-aspartate receptor-mediated component of synaptic transmission, which can be recorded in response to single shock stimulation of the Schaffer collateral-commissural pathway in the absence of added Mg2+ to the perfusate. MK-801 also prevented the induction of long term potentiation, which is normally produced in this pathway by high frequency stimulation in the presence of Mg2+.
ISSN:0304-3940
DOI:10.1016/0304-3940(87)90505-2