Search Results - "Sayre, Naomi L"

Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage by Sayre, Naomi L, Sifuentes, Mikaela, Holstein, Deborah, Cheng, Sheue-yann, Zhu, Xuguang, Lechleiter, James D

“…We previously demonstrated that stimulation of astrocyte mitochondrial ATP production via P2Y1 receptor agonists was neuroprotective after cerebral ischemic…”
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Inhibition of astrocyte hemichannel improves recovery from spinal cord injury by Zhang, Chao, Yan, Zhao, Maknojia, Asif, Riquelme, Manuel A, Gu, Sumin, Booher, Grant, Wallace, David J, Bartanusz, Viktor, Goswami, Akshay, Xiong, Wei, Zhang, Ningyan, Mader, Michael J, An, Zhiqiang, Sayre, Naomi L, Jiang, Jean X

“…Spinal cord injury (SCI) causes severe disability, and the current inability to restore function to the damaged spinal cord leads to lasting detrimental…”
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The Trifunctional Protein Mediates Thyroid Hormone Receptor-Dependent Stimulation of Mitochondria Metabolism by Chocron, E. Sandra, Sayre, Naomi L, Holstein, Deborah, Saelim, Nuttawut, Ibdah, Jamal A, Dong, Lily Q, Zhu, Xuguang, Cheng, Sheue-Yann, Lechleiter, James D

“…We previously demonstrated that the thyroid hormone, T3, acutely stimulates mitochondrial metabolism in a thyroid hormone receptor (TR)-dependent manner. T3…”
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Recovery from liver disease in a Niemann-Pick type C mouse model by Sayre, Naomi L., Rimkunas, Victoria M., Graham, Mark J., Crooke, Rosanne M., Liscum, Laura

“…Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C…”
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Loss of LRP1 in Adult Neural Stem Cells Impairs Migration to Ischemic Lesions by Dietert, Kristi, Mahesula, Swetha, Hegde, Sheetal, Verschelde, John, Reed, Pamela, Sprague, Shane, Kokovay, Erzsebet, Sayre, Naomi L

“…Abstract After ischemia, cells in the brain parenchyma upregulate stromal derived factor 1 (SDF1), driving chemokine receptor CXCR4-mediated migration of adult…”
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Acetazolamide Treatment Prevents Redistribution of Astrocyte Aquaporin 4 after Murine Traumatic Brain Injury by Glober, Nancy K., Sprague, Shane, Ahmad, Sadiya, Mayfield, Katherine G., Fletcher, Lauren M., Digicaylioglu, Murat H., Sayre, Naomi L.

“…After traumatic brain injury (TBI), multiple ongoing processes contribute to worsening and spreading of the primary injury to create a secondary injury. One…”
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Evaluation of an anti-tumor necrosis factor therapeutic in a mouse model of Niemann-Pick C liver disease by Vincent, Melanie, Sayre, Naomi L, Graham, Mark J, Crooke, Rosanne M, Shealy, David J, Liscum, Laura

“…Niemann-Pick type C (NPC) disease is a lysosomal storage disease characterized by the accumulation of cholesterol and glycosphingolipids. The majority of NPC…”
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Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment by Van Skike, Candice E, Jahrling, Jordan B, Olson, Angela B, Sayre, Naomi L, Hussong, Stacy A, Ungvari, Zoltan, Lechleiter, James D, Galvan, Veronica

“…An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-derived factors into the brain parenchyma. The BBB is damaged in…”
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Spinal cord injury and the human microbiome: beyond the brain-gut axis by Wallace, David J, Sayre, Naomi L, Patterson, T Tyler, Nicholson, Susannah E, Hilton, Donald, Grandhi, Ramesh

“…In addition to standard management for the treatment of the acute phase of spinal cord injury (SCI), implementation of novel neuroprotective interventions…”
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Thyroid hormones can increase astrocyte fatty acid oxidation and survival; a possible mechanism for decreased tissue necrosis after cerebral stroke by Sayre, Naomi L., Holstein, Deborah, Lechleiter, James D.

“…Abstract only Enhancement of astrocyte metabolism in mice significantly decreases lesion size after stroke. This was achieved after purinergic stimulation, but…”
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