Search Results - "Sayour, Alex Ali"
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Effect of pharmacological selectivity of SGLT2 inhibitors on cardiovascular outcomes in patients with type 2 diabetes: a meta-analysis
Published in Scientific reports (25-01-2024)“…Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce major adverse cardiovascular events (MACE) in type 2 diabetic (T2DM) patients. Pharmacological…”
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Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation
Published in Journal of translational medicine (16-04-2019)“…The sodium-glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a…”
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3
In a rat model of bypass DuraGraft ameliorates endothelial dysfunction of arterial grafts
Published in Scientific reports (02-07-2024)“…Coronary artery bypass surgery can result in endothelial dysfunction due to ischemia/reperfusion (IR) injury. Previous studies have demonstrated that DuraGraft…”
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Characterization of left ventricular myocardial sodium-glucose cotransporter 1 expression in patients with end-stage heart failure
Published in Cardiovascular diabetology (30-09-2020)“…Whereas selective sodium-glucose cotransporter 2 (SGLT2) inhibitors consistently showed cardiovascular protective effects in large outcome trials independent…”
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Effects of SGLT2 Inhibitors beyond Glycemic Control-Focus on Myocardial SGLT1
Published in International journal of molecular sciences (12-09-2021)“…Selective sodium-glucose cotransporter 2 (SGLT2) inhibitors reduced the risk of hospitalization for heart failure in patients with or without type 2 diabetes…”
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A Comparative Investigation of the Pulmonary Vasodilating Effects of Inhaled NO Gas Therapy and Inhalation of a New Drug Formulation Containing a NO Donor Metabolite (SIN-1A)
Published in International journal of molecular sciences (22-07-2024)“…Numerous research projects focused on the management of acute pulmonary hypertension as Coronavirus Disease 2019 (COVID-19) might lead to hypoxia-induced…”
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Pressure overload-induced systolic heart failure is associated with characteristic myocardial microRNA expression signature and post-transcriptional gene regulation in male rats
Published in Scientific reports (26-09-2023)“…Although systolic function characteristically shows gradual impairment in pressure overload (PO)-evoked left ventricular (LV) hypertrophy (LVH), rapid…”
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Pressure-volume analysis reveals characteristic sex-related differences in cardiac function in a rat model of aortic banding-induced myocardial hypertrophy
Published in American journal of physiology. Heart and circulatory physiology (01-09-2018)“…Sex differences in pressure overload (PO)-induced left ventricular (LV) myocardial hypertrophy (LVH) have been intensely investigated. Nevertheless,…”
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Preservation solution Custodiol containing human alpha-1-antitrypsin improves graft recovery after prolonged cold ischemic storage in a rat model of heart transplantation
Published in Frontiers in immunology (22-06-2023)“…The shortage of available donor hearts and the risk of ischemia/reperfusion injury restrict heart transplantation (HTX). Alpha-1-antitrypsin (AAT), a…”
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Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury
Published in Stem cell research & therapy (24-02-2021)“…Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to…”
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Sex-related differences of early cardiac functional and proteomic alterations in a rat model of myocardial ischemia
Published in Journal of translational medicine (11-12-2021)“…Reduced cardiovascular risk in premenopausal women has been the focus of research in recent decades. Previous hypothesis-driven experiments have highlighted…”
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Myocardial bridge: morphological factors which influence symptoms
Published in Orvosi hetilap (16-04-2023)“…Myocardial bridge is a frequently detected congenital coronary anomaly which is kept benign. It is unique because it can cause a dynamic compression during…”
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Graft Preservation Solution DuraGraft® Alleviates Vascular Dysfunction Following In Vitro Ischemia/Reperfusion Injury in Rats
Published in Pharmaceuticals (Basel, Switzerland) (09-10-2021)“…Vascular ischemia/reperfusion injury (IRI) in patients undergoing coronary artery bypass grafting can result in graft failure and the need for repeat…”
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Sex Differences in Morphological and Functional Aspects of Exercise-Induced Cardiac Hypertrophy in a Rat Model
Published in Frontiers in physiology (12-07-2019)“…Recent evidences suggest that sex hormones may be involved in the regulation of exercise-induced left ventricular (LV) hypertrophy. However, the sex-specific…”
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15
Heterotopic Abdominal Rat Heart Transplantation as a Model to Investigate Volume Dependency of Myocardial Remodeling
Published in Transplantation (01-03-2017)“…ABSTRACTHeterotopic abdominal rat heart transplantation has been extensively used to investigate ischemic-reperfusion injury, immunological consequences during…”
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Pharmacological preconditioning with gemfibrozil preserves cardiac function after heart transplantation
Published in Scientific reports (27-10-2017)“…While heart transplantation (HTX) is the definitive therapy of heart failure, donor shortage is emerging. Pharmacological activation of soluble guanylate…”
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Myocardial work index: a marker of left ventricular contractility in pressure‐ or volume overload‐induced heart failure
Published in ESC Heart Failure (01-06-2021)“…Aims While global longitudinal strain (GLS) is considered to be a sensitive marker of left ventricular (LV) function, it is significantly influenced by loading…”
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Inflammasome activation in end‐stage heart failure‐associated atrial fibrillation
Published in ESC Heart Failure (01-08-2022)“…Aims Inflammatory pathways are increasingly recognized as an important factor in the pathophysiology of both heart failure (HF) and atrial fibrillation (AF)…”
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The effects of acute and elective cardiac surgery on the anxiety traits of patients with Marfan syndrome
Published in BMC psychiatry (17-07-2017)“…Marfan syndrome is a genetic disease, presenting with dysfunction of connective tissues leading to lesions in the cardiovascular and skeletal muscle system…”
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Left Ventricular SGLT1 Protein Expression Correlates with the Extent of Myocardial Nitro-Oxidative Stress in Rats with Pressure and Volume Overload-Induced Heart Failure
Published in Antioxidants (26-07-2021)“…Myocardial sodium-glucose cotransporter 1 (SGLT1) has been shown to be upregulated in humans with heart failure (HF) with or without diabetes. In vitro studies…”
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