Search Results - "Sayos, J"

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM by Sayos, J, Terhorst, C, Wu, C, Morra, M, Wang, N, Zhang, X, Allen, D, van Schaik, S, Notarangelo, L, Geha, R, Roncarolo, M. G, Oettgen, H, De Vries, J. E, Aversa, G

“…In addition to triggering the activation of B- or T-cell antigen receptors, the binding of a ligand to its receptor at the cell surface can sometimes determine…”
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Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature . 1998. 395: 462-469 by Sayos, J, Wu, C, Morra, M, Wang, N, Zhang, X, Allen, D, van Schaik, S, Notarangelo, L, Geha, R, Roncarolo, M G, Oettgen, H, De Vries, J E, Aversa, G, Terhorst, C

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X-LINKED LYMPHOPROLIFERATIVE DISEASE: A Progressive Immunodeficiency by Morra, Massimo, Howie, Duncan, Grande, Maria Simarro, Sayos, Joan, Wang, Ninghai, Wu, Chengbin, Engel, Pablo, Terhorst, Cox

“…Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the last two years. The gene that is altered in the…”
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The IL‐2RG R328X nonsense mutation allows partial STAT‐5 phosphorylation and defines a critical region involved in the leaky‐SCID phenotype by Arcas‐García, A., Garcia‐Prat, M., Magallón‐Lorenz, M., Martín‐Nalda, A., Drechsel, O., Ossowski, S., Alonso, L., Rivière, J. G., Soler‐Palacín, P., Colobran, R., Sayós, J., Martínez‐Gallo, M., Franco‐Jarava, C.

“…Summary In addition to their detection in typical X‐linked severe combined immunodeficiency, hypomorphic mutations in the interleukin (IL)‐2 receptor common…”
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Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP by Sayós, Joan, Martı́n, Margarita, Chen, Alice, Simarro, Marı́a, Howie, Duncan, Morra, Massimo, Engel, Pablo, Terhorst, Cox

“…X-linked lymphoproliferative disease (XLP) is a rare immune disorder commonly triggered by infection with Epstein-Barr virus. Major disease manifestations…”
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Phosphorylation of adenosine in renal brush-border membrane vesicles by an exchange reaction catalysed by adenosine kinase by SAYOS, J, SOLSONA, C, MALLOL, J, LLUIS, C, FRANCO, R

“…Uptake of [3H]adenosine in brush-border membrane (BBM) vesicles from either rat or pig kidney leads to an accumulation of intravesicular [3H]AMP. The lack of…”
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Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4 by Sayós, Joan, Nguyen, Khuong B., Wu, Chengbin, Stepp, Susan E., Howie, Duncan, Schatzle, John D., Kumar, Vinay, Biron, Christine A., Terhorst, Cox

“…SAP, the gene that is altered or absent in the X-linked lymphoproliferative syndrome (XLP), encodes a small protein that comprises a single SH2 domain and…”
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Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition by Poy, Florence, Yaffe, Michael B, Sayos, Joan, Saxena, Kumkum, Morra, Massimo, Sumegi, Janos, Cantley, Lewis C, Terhorst, Cox, Eck, Michael J

“…SAP, the product of the gene mutated in X-linked lymphoproliferative syndrome (XLP), consists of a single SH2 domain that has been shown to bind the…”
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IREM‐1 is a novel inhibitory receptor expressed by myeloid cells by Alvarez‐Errico, Damiana, Aguilar, Helena, Kitzig, Friederike, Brckalo, Tamara, Sayós, Joan, López‐Botet, Miguel

“…Using a three‐hybrid strategy, we have identified a novel cell surface molecule which interacts with the Src homology 2 (SH2) domains of SH2 domain‐containing…”
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Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation by Howie, Duncan, Simarro, Marı́a, Sayos, Joan, Guirado, Maria, Sancho, Jaime, Terhorst, Cox

“…CD150 signaling lymphocytic activation molecule (SLAM), a T/B/dendritic cell surface glycoprotein, is a costimulatory receptor involved in T-cell activation…”
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Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells by Morra, Massimo, Lu, Jun, Poy, Florence, Martin, Margarita, Sayos, Joan, Calpe, Silvia, Gullo, Charles, Howie, Duncan, Rietdijk, Svend, Thompson, Andrew, Coyle, Anthony J., Denny, Christopher, Yaffe, Michael B., Engel, Pablo, Eck, Michael J., Terhorst, Cox

“…The T and natural killer (NK) cell‐specific gene SAP (SH2D1A) encodes a ‘free SH2 domain’ that binds a specific tyrosine motif in the cytoplasmic tail of SLAM…”
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Recruitment of C-terminal Src kinase by the leukocyte inhibitory receptor CD85j by Sayós, Joan, Martínez-Barriocanal, Agueda, Kitzig, Friederike, Bellón, Teresa, López-Botet, Miguel

“…The CD85j inhibitory receptor (also termed ILT2 or LIR-1) is a type-I transmembrane protein that belongs to the Ig superfamily and is expressed by different…”
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Molecular Characterization of a Novel Immune Receptor Restricted to the Monocytic Lineage by Aguilar, Helena, Alvarez-Errico, Damiana, Garcia-Montero, Andres C, Orfao, Alberto, Sayos, Joan, Lopez-Botet, Miguel

“…Homology basic local alignment search tool search was conducted using a sequence encoding for a novel inhibitory receptor (IREM-1) cloned in our laboratory and…”
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Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM) by Sayos, J, Centelles, J J, Mallol, J, Canela, E I, Lluis, C, Franco, R

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Mutational Analysis of Immunoreceptor Tyrosine-Based Inhibition Motifs of the Ig-Like Transcript 2 (CD85j) Leukocyte Receptor by Bellon, Teresa, Kitzig, Friederike, Sayos, Joan, Lopez-Botet, Miguel

“…The inhibitory receptor Ig-like transcript (ILT)2 (leukocyte Ig-like receptor or CD85j) is a type I transmembrane protein expressed by different leukocyte…”
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The gene defective in X-linked lymphoproliferative disease controls T cell dependent immune surveillance against Epstein–Barr virus by Howie, Duncan, Sayos, Juan, Terhorst, Cox, Morra, Massimo

“…Our understanding of the X-linked lymphoproliferative syndrome (XLP) has advanced significantly in the past two years. The gene that is aberrant in the…”
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Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1 by Kitzig, Friederike, Martinez-Barriocanal, Águeda, López-Botet, Miguel, Sayós, Joan

“…Using a three-hybrid strategy in yeast, we have cloned a new splice variant of Siglec-10, called Siglec-10 Sv3. This splice variant lacks part of exon 3, but…”
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Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease by Wu, C, Sayos, J, Wang, N, Howie, D, Coyle, A, Terhorst, C

“…X-linked lymphoproliferative (XLP) disease is a fatal immunological disorder that renders the immune system unable to respond effectively to Epstein-Barr virus…”
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Regulation of nitrobenzylthioninosine-sensitive adenosine uptake by cultured kidney cells by Sayós, J, Blanco, J, Ciruela, F, Canela, E I, Mallol, J, Lluis, C, Franco, R

“…The effect of nitrobenzylthioinosine (NBTI) on [3H]adenosine uptake and the characterization of the [3H]NBTI binding in cell (primary cultures and LLC-PK1 cell…”
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Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes by Blanco, J, Canela, E I, Sayós, J, Mallol, J, Lluis, C, Franco, R

“…Exogenous adenosine triphosphate (ATP) added to brush-border membrane vesicles was rapidly degraded mainly to inosine according to the high ecto-nucleotidase…”
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