Search Results - "Sayers, Ian"

Epithelial cell dysfunction, a major driver of asthma development by Heijink, Irene H., Kuchibhotla, Virinchi N. S., Roffel, Mirjam P., Maes, Tania, Knight, Darryl A., Sayers, Ian, Nawijn, Martijn C.

“…Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway…”
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IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction by Barlow, Jillian L., PhD, Peel, Samantha, PhD, Fox, Jane, PhD, Panova, Veera, MRes, Hardman, Clare S., BSc, Camelo, Ana, PhD, Bucks, Christine, PhD, Wu, Xiaoying, MD, Kane, Colleen M., PhD, Neill, Daniel R., PhD, Flynn, Robin J., PhD, Sayers, Ian, PhD, Hall, Ian P., DM, McKenzie, Andrew N.J., PhD

“…Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse studies suggest their immunologic functions in type 2 immunity are…”
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Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study by Shrine, Nick, Portelli, Michael A, John, Catherine, Soler Artigas, María, Bennett, Neil, Hall, Robert, Lewis, Jon, Henry, Amanda P, Billington, Charlotte K, Ahmad, Azaz, Packer, Richard J, Shaw, Dominick, Pogson, Zara E K, Fogarty, Andrew, McKeever, Tricia M, Singapuri, Amisha, Heaney, Liam G, Mansur, Adel H, Chaudhuri, Rekha, Thomson, Neil C, Holloway, John W, Lockett, Gabrielle A, Howarth, Peter H, Djukanovic, Ratko, Hankinson, Jenny, Niven, Robert, Simpson, Angela, Chung, Kian Fan, Sterk, Peter J, Blakey, John D, Adcock, Ian M, Hu, Sile, Guo, Yike, Obeidat, Maen, Sin, Don D, van den Berge, Maarten, Nickle, David C, Bossé, Yohan, Tobin, Martin D, Hall, Ian P, Brightling, Christopher E, Wain, Louise V, Sayers, Ian

“…Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see…”
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Phenotypic and functional translation of IL33 genetics in asthma by Ketelaar, Maria E., Portelli, Michael A., Dijk, F. Nicole, Shrine, Nick, Faiz, Alen, Vermeulen, Cornelis J., Xu, Cheng J., Hankinson, Jenny, Bhaker, Sangita, Henry, Amanda P., Billington, Charlote K., Shaw, Dominick E., Johnson, Simon R., Benest, Andrew V., Pang, Vincent, Bates, David O., Pogson, Z.E.K., Fogarty, Andrew, McKeever, Tricia M., Singapuri, Amisha, Heaney, Liam G., Mansur, Adel H., Chaudhuri, Rekha, Thomson, Neil C., Holloway, John W., Lockett, Gabrielle A., Howarth, Peter H., Niven, Robert, Simpson, Angela, Tobin, Martin D., Hall, Ian P., Wain, Louise V., Blakey, John D., Brightling, Christopher E., Obeidat, Ma'en, Sin, Don D., Nickle, David C., Bossé, Yohan, Vonk, Judith M., van den Berge, Maarten, Koppelman, Gerard H., Sayers, Ian, Nawijn, Martijn C.

“…Asthma is a complex disease with multiple phenotypes that may differ in disease pathobiology and treatment response. IL33 single nucleotide polymorphisms…”
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Lung function associated gene Integrator Complex subunit 12 regulates protein synthesis pathways by Kheirallah, Alexander K, de Moor, Cornelia H, Faiz, Alen, Sayers, Ian, Hall, Ian P

“…Genetic studies of human lung function and Chronic Obstructive Pulmonary Disease have identified a highly significant and reproducible signal on 4q24. It…”
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Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank by Fawcett, Katherine A, Demidov, German, Shrine, Nick, Paynton, Megan L, Ossowski, Stephan, Sayers, Ian, Wain, Louise V, Hollox, Edward J

“…The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring…”
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Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? by Thompson, Rebecca J, Sayers, Ian, Kuokkanen, Katja, Hall, Ian P

“…Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and…”
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Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice by Liu, Bo, Henry, Amanda P, Azimi, Sheyda, Miller, Suzanne, Lee, Frank K, Lee, Jane C, Probert, Kelly, Kotlikoff, Michael I, Sayers, Ian, Hall, Ian P

“…Genome-Wide Association Studies suggest glutathione S transferase C terminal domain (GSTCD) may play a role in development of Chronic Obstructive Pulmonary…”
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Transcriptomics using lung resection material to advance our understanding of COPD and idiopathic pulmonary fibrosis pathogenesis by Rakkar, Kamini, Thakker, Dhruma, Portelli, Michael A, Hall, Ian, Schlüter, Holger, Sayers, Ian

“…https://bit.ly/3JoW73H…”
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Evidence of a genetic contribution to lung function decline in asthma by Koppelman, Gerard H., MD, PhD, Sayers, Ian, PhD

“…There has been great progress in identifying new asthma susceptibility genes. In asthmatic subjects there is variable airway remodeling that includes features…”
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Defining a role for lung function associated gene GSTCD in cell homeostasis by Henry, Amanda P, Probert, Kelly, Stewart, Ceri E, Thakker, Dhruma, Bhaker, Sangita, Azimi, Sheyda, Hall, Ian P, Sayers, Ian

“…Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione…”
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Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity by Portelli, Michael A, Bhaker, Sangita, Pang, Vincent, Bates, David O, Johnson, Simon R, Mazar, Andrew P, Shaw, Dominick, Brightling, Christopher, Sayers, Ian

“…Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma…”
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Human bronchial epithelial cells from patients with asthma have an altered gene expression profile by Bhaker, Sangita, Portelli, Michael A, Rakkar, Kamini, Shaw, Dominick, Johnson, Simon, Brightling, Christopher, Sayers, Ian

“…https://bit.ly/3Cq2xKf…”
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Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls by Artigas, María Soler, Wain, Louise V, Shrine, Nick, McKeever, Tricia M, Sayers, Ian, Hall, Ian P, Tobin, Martin D

“…Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide; smoking is the main risk factor for COPD, but genetic factors are…”
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Meta-analysis of genome-wide linkage studies of asthma and related traits by Denham, Samuel, Koppelman, Gerard H, Blakey, John, Wjst, Matthias, Ferreira, Manuel A, Hall, Ian P, Sayers, Ian

“…Asthma and allergy are complex multifactorial disorders, with both genetic and environmental components determining disease expression. The use of molecular…”
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PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline by Barton, Sheila J., MSc, Koppelman, Gerard H., MD, PhD, Vonk, Judith M., PhD, Browning, Claudia A., BSc, Nolte, Ilja M., PhD, Stewart, Ceri E., PhD, Bainbridge, Sue, BSc, Mutch, Stacey, BSc, Rose-Zerilli, Matthew J., BSc, Postma, Dirkje S., MD, PhD, Maniatis, Nikolas, PhD, Henry, Amanda P., PhD, Hall, Ian P., MD, DM, Holgate, Stephen T., MD, DSc, Tighe, Patrick, PhD, Holloway, John W., PhD, Sayers, Ian, PhD

“…Background Several studies have suggested that chromosome 19q13.1-3 contains asthma susceptibility genes. Objective Linkage and association analyses using 587…”
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Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis by Guillen-Guio, Beatriz, Paynton, Megan L, Allen, Richard J, Chin, Daniel P W, Donoghue, Lauren J, Stockwell, Amy, Leavy, Olivia C, Hernandez-Beeftink, Tamara, Reynolds, Carl, Cullinan, Paul, Martinez, Fernando, Booth, Helen L, Fahy, William A, Hall, Ian P, Hart, Simon P, Hill, Mike R, Hirani, Nik, Hubbard, Richard B, McAnulty, Robin J, Millar, Ann B, Navaratnam, Vidya, Oballa, Eunice, Parfrey, Helen, Saini, Gauri, Sayers, Ian, Tobin, Martin D, Whyte, Moira K B, Adegunsoye, Ayodeji, Kaminski, Naftali, Ma, Shwu-Fan, Strek, Mary E, Zhang, Yingze, Fingerlin, Tasha E, Molina-Molina, Maria, Neighbors, Margaret, Sheng, X Rebecca, Oldham, Justin M, Maher, Toby M, Molyneaux, Philip L, Flores, Carlos, Noth, Imre, Schwartz, David A, Yaspan, Brian L, Jenkins, R Gisli, Wain, Louise V, Hollox, Edward J

“…Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have…”
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Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium by Portelli, Michael A, Dijk, F Nicole, Ketelaar, Maria E, Shrine, Nick, Hankinson, Jenny, Bhaker, Sangita, Grotenboer, Néomi S, Obeidat, Ma'en, Henry, Amanda P, Billington, Charlotte K, Shaw, Dominick, Johnson, Simon R, Pogson, Zara Ek, Fogarty, Andrew, McKeever, Tricia M, Nickle, David C, Bossé, Yohan, van den Berge, Maarten, Faiz, Alen, Brouwer, Sharon, Vonk, Judith M, de Vos, Paul, Brandsma, Corry-Anke, Vermeulen, Cornelis J, Singapuri, Amisha, Heaney, Liam G, Mansur, Adel H, Chaudhuri, Rekha, Thomson, Neil C, Holloway, John W, Lockett, Gabrielle A, Howarth, Peter H, Niven, Robert, Simpson, Angela, Blakey, John D, Tobin, Martin D, Postma, Dirkje S, Hall, Ian P, Wain, Louise V, Nawijn, Martijn C, Brightling, Christopher E, Koppelman, Gerard H, Sayers, Ian

“…The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution of single nucleotide polymorphisms (SNPs) in this locus to specific…”
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β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study by Hall, Ian P, Blakey, John D, Al Balushi, Khalid A, Wheatley, Amanda, Sayers, Ian, Pembrey, Marcus E, Ring, Susan M, McArdle, Wendy L, Strachan, David P

“…Functionally relevant polymorphisms of the β2-adrenoceptor gene ( ADRB2) are common in white populations, but their contribution to the burden of airways…”
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Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity by O'Loughlin, Jonathan, Hall, Robert J, Bhaker, Sangita, Portelli, Michael A, Henry, Amanda, Pang, Vincent, Bates, David O, Sharp, Tyson V, Sayers, Ian

“…Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently…”
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