Search Results - "Sayers, Edward"

Cell entry of cell penetrating peptides: tales of tails wagging dogs by Jones, Arwyn T., Sayers, Edward J.

“…Cell penetrating peptides hold considerable potential for academic and pharmaceutical remits with an interest in delivering macromolecules to the insides of…”
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Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines by Patel, Sanjay G., Sayers, Edward J., He, Lin, Narayan, Rohan, Williams, Thomas L., Mills, Emily M., Allemann, Rudolf K., Luk, Louis Y. P., Jones, Arwyn T., Tsai, Yu-Hsuan

“…Protein therapy holds great promise for treating a variety of diseases. To act on intracellular targets, therapeutic proteins must cross the plasma membrane…”
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Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression by Sayers, Edward J., Peel, Samantha E., Schantz, Anna, England, Richard M., Beano, Maya, Bates, Stephanie M., Desai, Arpan S., Puri, Sanyogitta, Ashford, Marianne B., Jones, Arwyn T.

“…Lipid nanoparticles have great potential for delivering nucleic-acid-based therapeutics, but low efficiency limits their broad clinical translation…”
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Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes by Nödling, Alexander R, Mills, Emily M, Li, Xuefei, Cardella, Davide, Sayers, Edward J, Wu, Shih-Hsiung, Jones, Arwyn T, Luk, Louis Y P, Tsai, Yu-Hsuan

“…Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting…”
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Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes by Moody, Paul R, Sayers, Edward J, Magnusson, Johannes P, Alexander, Cameron, Borri, Paola, Watson, Peter, Jones, Arwyn T

“…A major unmet clinical need is a universal method for subcellular targeting of bioactive molecules to lysosomes. Delivery to this organelle enables either…”
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Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies by Aikman, Brech, Bonsignore, Riccardo, Woods, Ben, Doellerer, Daniel, Scotti, Riccardo, Schmidt, Claudia, Heidecker, Alexandra A, Pöthig, Alexander, Sayers, Edward J, Jones, Arwyn T, Casini, Angela

“…With the aim of designing new metallosupramolecular architectures for drug delivery, research has focused on porous 3-dimensional (3D)-metallacages able to…”
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Highly luminescent metallacages featuring bispyridyl ligands functionalised with BODIPY for imaging in cancer cells by Woods, Ben, Döllerer, Daniel, Aikman, Brech, Wenzel, Margot N., Sayers, Edward J., Kühn, Fritz E., Jones, Arwyn T., Casini, Angela

“…Recently, 3-dimensional supramolecular coordination complexes of the metallacage type have been shown to hold promise as drug delivery systems for different…”
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Quantitative Subcellular Analysis of Cyclic Cell-Penetrating Peptide EJP18 in Nonadherent Cells by Sayers, Edward J, Barlow, Victoria L, Tsai, Yu-Hsuan, Jones, Arwyn T

“…Cyclization of cell-penetrating peptides (CPPs) often results in improved capacity for intracellular delivery of a range of cargoes but quantitating the…”
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Cell-Penetrating Antimicrobial Peptides – Prospectives for Targeting Intracellular Infections by Bahnsen, Jesper S., Franzyk, Henrik, Sayers, Edward J., Jones, Arwyn T., Nielsen, Hanne M.

“…ABSTRACT Purpose To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides. Methods Cellular uptake of…”
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Modification of the Antibiotic, Colistin, with Dextrin Causes Enhanced Cytotoxicity and Triggers Apoptosis in Myeloid Leukemia by Rizzo, Siân, Varache, Mathieu, Sayers, Edward J, Jones, Arwyn T, Tonks, Alex, Thomas, David W, Ferguson, Elaine L

“…Acute myeloid leukemia (AML) remains difficult to treat due to its heterogeneity in molecular landscape, epigenetics and cell signaling alterations. Precision…”
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Targeted delivery and endosomal cellular uptake of DARPin-siRNA bioconjugates: Influence of linker stability on gene silencing by Lorenzer, Cornelia, Streußnig, Sonja, Tot, Emilia, Winkler, Anna-Maria, Merten, Hannes, Brandl, Fabian, Sayers, Edward J., Watson, Peter, Jones, Arwyn T., Zangemeister-Wittke, Uwe, Plückthun, Andreas, Winkler, Johannes

“…[Display omitted] Specific cell targeting and efficient intracellular delivery are major hurdles for the widespread therapeutic use of nucleic acid…”
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Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin by Birch, Ditlev, Sayers, Edward J, Christensen, Malene V, Jones, Arwyn T, Franzyk, Henrik, Nielsen, Hanne M

“…Cell-penetrating peptides (CPPs), such as penetratin, are often investigated as drug delivery vectors and incorporating d-amino acids, rather than the natural…”
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Four-wave-mixing microscopy reveals non-colocalisation between gold nanoparticles and fluorophore conjugates inside cells by Giannakopoulou, Naya, Williams, Joseph B, Moody, Paul R, Sayers, Edward J, Magnusson, Johannes P, Pope, Iestyn, Payne, Lukas, Alexander, Cameron, Jones, Arwyn T, Langbein, Wolfgang, Watson, Peter, Borri, Paola

“…Gold nanoparticles have been researched for many biomedical applications in diagnostics, theranostics, and as drug delivery systems. When conjugated to…”
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Switching of Macromolecular Ligand Display by Thermoresponsive Polymers Mediates Endocytosis of Multiconjugate Nanoparticles by Sayers, Edward J, Magnusson, Johannes P, Moody, Paul R, Mastrotto, Francesca, Conte, Claudia, Brazzale, Chiara, Borri, Paola, Caliceti, Paolo, Watson, Peter, Mantovani, Giuseppe, Aylott, Jonathan, Salmaso, Stefano, Jones, Arwyn T, Alexander, Cameron

“…Ligand-mediated targeting and internalization of plasma membrane receptors is central to cellular function. These types of receptors have accordingly been…”
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Influence of Folate-Targeted Gold Nanoparticles on Subcellular Localization and Distribution into Lysosomes by Daniele, Raffaella, Brazzale, Chiara, Arpac, Busra, Tognetti, Francesco, Pesce, Cristiano, Malfanti, Alessio, Sayers, Edward, Mastrotto, Francesca, Jones, Arwyn T, Salmaso, Stefano, Caliceti, Paolo

“…The cell interaction, mechanism of cell entry and intracellular fate of surface decorated nanoparticles are known to be affected by the surface density of…”
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Co-operative Membrane Disruption Between Cell-penetrating Peptide and Cargo: Implications for the Therapeutic Use of the Bcl-2 Converter Peptide D-NuBCP-9-r8 by Watkins, Catherine L, Sayers, Edward J, Allender, Chris, Barrow, David, Fegan, Christopher, Brennan, Paul, Jones, Arwyn T

“…Delivering apoptosis inducing peptides to cells is an emerging area in cancer and molecular therapeutics. Here, we have identified an alternative mechanism of…”
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siRNA Inhibition of Endocytic Pathways to Characterize the Cellular Uptake Mechanisms of Folate-Functionalized Glycol Chitosan Nanogels by Pereira, Paula, Pedrosa, Sílvia S, Wymant, Jennifer M, Sayers, Edward, Correia, Alexandra, Vilanova, Manuel, Jones, Arwyn T, Gama, Francisco M

“…Glycol chitosan nanogels have been widely used in gene, drug, and contrast agent delivery in an effort to improve disease diagnosis and treatment. Herein, we…”
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Fluid-Phase Endocytosis and Lysosomal Degradation of Bovine Lactoferrin in Lung Cells by Sayers, Edward John, Palmer, Iwan, Hope, Lucy, Hope, Paul, Watson, Peter, Jones, Arwyn Tomos

“…The iron-binding protein lactoferrin and the cell-penetrating peptides derived from its sequence utilise endocytosis to enter different cell types. The…”
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Strategic Trastuzumab Mediated Crosslinking Driving Concomitant HER2 and HER3 Endocytosis and Degradation in Breast Cancer by Wymant, Jennifer Mary, Sayers, Edward John, Muir, Duncan, Jones, Arwyn Tomos

“…Efficacious anticancer therapies for targeting plasma membrane receptors with antibody based therapeutics are often contingent on sufficient endocytic delivery…”
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Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation by Padalino, Gilda, El-Sakkary, Nelly, Liu, Lawrence J., Liu, Chenxi, Harte, Danielle S.G., Barnes, Rachel E., Sayers, Edward, Forde-Thomas, Josephine, Whiteland, Helen, Bassetto, Marcella, Ferla, Salvatore, Johnson, George, Jones, Arwyn T., Caffrey, Conor R., Chalmers, Iain, Brancale, Andrea, Hoffmann, Karl F.

“…Schistosomiasis is a neglected disease of poverty that is caused by infection with blood fluke species contained within the genus Schistosoma. For the last 40…”
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