Search Results - "Sayegh, MH"

Calcineurin inhibitors: 40 years later, can't live without by Azzi, Jamil R, Sayegh, Mohamed H, Mallat, Samir G

“…Calcineurin inhibitors (CNIs) revolutionized the field of organ transplantation and remain the standard of care 40 years after the discovery of cyclosporine…”
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Delayed graft function in kidney transplantation by Perico, Norberto, Cattaneo, Dario, Sayegh, Mohamed H, Remuzzi, Giuseppe

“…Delayed graft function is a form of acute renal failure resulting in post-transplantation oliguria, increased allograft immunogenicity and risk of acute…”
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Tissue expression of PD-L1 mediates peripheral T cell tolerance by Keir, Mary E, Liang, Spencer C, Guleria, Indira, Latchman, Yvette E, Qipo, Andi, Albacker, Lee A, Koulmanda, Maria, Freeman, Gordon J, Sayegh, Mohamed H, Sharpe, Arlene H

“…Programmed death 1 (PD-1), an inhibitory receptor expressed on activated lymphocytes, regulates tolerance and autoimmunity. PD-1 has two ligands: PD-1 ligand 1…”
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Transplantation 50 Years Later — Progress, Challenges, and Promises by Sayegh, Mohamed H, Carpenter, Charles B

“…A half-century has elapsed since the first transplantation, and this procedure is now accepted as the treatment of choice for end-stage organ failure. This…”
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ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma by FRANK, Natasha Y, MARGARYAN, Armen, YING HUANG, SCHATTON, Tobias, WAAGA-GASSER, Ana Maria, GASSER, Martin, SAYEGH, Mohamed H, SADEE, Wolfgang, FRANK, Markus H

“…Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette transporters is one of several mechanisms of multidrug resistance…”
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The roles of the new negative T cell costimulatory pathways in regulating autoimmunity by Khoury, Samia J, Sayegh, Mohamed H

“…The B7 family of T cell costimulatory molecules has recently acquired several new members. Some of these are activating while others are inhibitory. In this…”
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A critical role for the programmed death ligand 1 in fetomaternal tolerance by Guleria, Indira, Khosroshahi, Arezou, Ansari, Mohammed Javeed, Habicht, Antje, Azuma, Miyuki, Yagita, Hideo, Noelle, Randolph J, Coyle, Anthony, Mellor, Andrew L, Khoury, Samia J, Sayegh, Mohamed H

“…Fetal survival during gestation implies that tolerance mechanisms suppress the maternal immune response to paternally inherited alloantigens. Here we show that…”
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T-cell costimulatory pathways in allograft rejection and tolerance by Rothstein, David M., Sayegh, Mohamed H.

“…The destiny of activated T cells is critical to the ultimate fate of immune response. After encountering antigen, naïve T cells receive signal 1 through the…”
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Memory T cells: A hurdle to immunologic tolerance by LAKKIS, Fadi G, SAYEGH, Mohamed H

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The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice by Ansari, Mohammed Javeed I, Salama, Alan D, Chitnis, Tanuja, Smith, R Neal, Yagita, Hideo, Akiba, Hisaya, Yamazaki, Tomohide, Azuma, Miyuki, Iwai, Hideyuki, Khoury, Samia J, Auchincloss, Jr, Hugh, Sayegh, Mohamed H

“…Programmed death-1 (PD-1) receptor, an inhibitory costimulatory molecule found on activated T cells, has been demonstrated to play a role in the regulation of…”
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T-cell costimulatory pathways in allograft rejection and tolerance by CLARKSON, Michael R, SAYEGH, Mohamed H

“…A key factor driving the underlying pathyphysiology of "chronic rejection" in organ transplantation is a persistent T cell-mediated alloimmune response…”
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Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis by Salama, Alan D, Chitnis, Tanuja, Imitola, Jaime, Ansari, Mohammed Javeed I, Akiba, Hisaya, Tushima, Fumihiko, Azuma, Miyuki, Yagita, Hideo, Sayegh, Mohamed H, Khoury, Samia J

“…Experimental autoimmune encephalomyelitis (EAE) is mediated by autoantigen-specific T cells dependent on critical costimulatory signals for their full…”
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Organ trafficking and transplant tourism and commercialism: the Declaration of Istanbul by Abbud, M, Al-Mousawi, M, Alobaidli, AA, Al-Rukhaimi, MN, Bagheri, A, Bakr, MA, Barbari, A, Capron, A, Chapman, JR, Couser, W, Danovitch, G, de Castro, LD, Delmonico, FL, Fazel, I, Haberal, M, Jha, V, Kobayashi, E, Lameire, N, Levin, A, Maiga, MK, Martin, D, Masri, M, Naicker, S, Noel, L, Rizvi, SAH, Rodriguez-Iturbe, B, Sayegh, MH, Shaheen, FAM, Stephan, AG, Tibell, A, Tong, MKL, Vathsala, A

“…Vulnerable populations (such as illiterate and impoverished individuals, undocumented immigrants, prisoners, and political or economic refugees) in…”
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Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance by Zheng, Xin Xiao, Sánchez-Fueyo, Alberto, Sho, Masayuki, Domenig, Christoph, Sayegh, Mohamed H, Strom, Terry B

“…Therapeutic application of broadly reactive anti-T cell antibodies can lead not only to potent immunosuppression but also to profound and long-lived T cell…”
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Homeostatic proliferation is a barrier to transplantation tolerance by Turka, Laurence A, Wu, Zihao, Bensinger, Steven J, Zhang, Jidong, Chen, Chuangqi, Yuan, Xueli, Huang, Xiaolun, Markmann, James F, Kassaee, Alireza, Rosengard, Bruce R, Hancock, Wayne W, Sayegh, Mohamed H

“…Despite the ease of inhibiting immune responses by blockade of T-cell costimulation in naive rodent models, it is difficult to suppress those responses in…”
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Regulatory functions of CD8+CD28– T cells in an autoimmune disease model by Najafian, Nader, Chitnis, Tanuja, Salama, Alan D., Zhu, Bing, Benou, Christina, Yuan, Xueli, Clarkson, Michael R., Sayegh, Mohamed H., Khoury, Samia J.

“…CD8 + T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8 –/– CD28 –/–…”
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Regulatory CD25+ T cells in human kidney transplant recipients by SALAMA, Alan D, NAJAFIAN, Nader, CLARKSON, Michael R, HARMON, William E, SAYEGH, Mohamed H

“…Recent evidence suggests that a population of professional regulatory cells, which limit immune responsiveness, exist in rodents and healthy human subjects…”
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Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment by Sykes, Megan, Wekerle, Thomas, Kurtz, Josef, Ito, Hiroshi, Ronquillo, Joseph V, Dong, Victor, Zhao, Guiling, Shaffer, Juanita, Sayegh, Mohamed H

“…Allogeneic bone marrow transplantation (in immunocompetent adults) has always required cytoreductive treatment of recipients with irradiation or cytotoxic…”
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Regulation of Progenitor Cell Fusion by ABCB5 P-glycoprotein, a Novel Human ATP-binding Cassette Transporter by Frank, Natasha Y., Pendse, Shona S., Lapchak, Peter H., Margaryan, Armen, Shlain, Debbie, Doeing, Carsten, Sayegh, Mohamed H., Frank, Markus H.

“…Cell fusion involving progenitor cells is a newly recognized phenomenon thought to contribute to tissue differentiation. The molecular mechanisms governing…”
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CD4+ T Cells Mediate Abscess Formation in Intra-abdominal Sepsis by an IL-17-Dependent Mechanism by Chung, Doo Ryeon, Kasper, Dennis L, Panzo, Ronald J, Chtinis, Tanuja, Grusby, Michael J, Sayegh, Mohamed H, Tzianabos, Arthur O

“…Abscess formation associated with intra-abdominal sepsis causes severe morbidity and can be fatal. Previous studies have implicated T cells in the pathogenesis…”
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