Search Results - "Sayaman, Rosalyn W."

Discriminating external and internal causes for heading changes in freely flying Drosophila by Censi, Andrea, Straw, Andrew D, Sayaman, Rosalyn W, Murray, Richard M, Dickinson, Michael H

“…As animals move through the world in search of resources, they change course in reaction to both external sensory cues and internally-generated programs…”
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications by Shan, Jingxuan, Chouchane, Aziz, Mokrab, Younes, Saad, Mohamad, Boujassoum, Salha, Sayaman, Rosalyn W, Ziv, Elad, Bouaouina, Noureddine, Remadi, Yasmine, Gabbouj, Sallouha, Roelands, Jessica, Ma, Xiaojing, Bedognetti, Davide, Chouchane, Lotfi

“…Triple-negative breast cancer (TNBC) accounts for ~15-20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other…”
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Analytic pipelines to assess the relationship between immune response and germline genetics in human tumors by Sayaman, Rosalyn W., Saad, Mohamad, Heimann, Carolina, Hu, Donglei, Kunji, Khalid, Roelands, Jessica, Wolf, Denise M., Huntsman, Scott, Ceccarelli, Michele, Thorsson, Vésteinn, Ziv, Elad, Bedognetti, Davide

“…Germline genetic variants modulate human immune response. We present analytical pipelines for assessing the contribution of hosts’ genetic background to the…”
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Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry by Roelands, Jessica, Mall, Raghvendra, Almeer, Hossam, Thomas, Remy, Mohamed, Mahmoud G., Bedri, Shahinaz, Al-Bader, Salha Bujassoum, Junejo, Kulsoom, Ziv, Elad, Sayaman, Rosalyn W., Kuppen, Peter J. K., Bedognetti, Davide, Hendrickx, Wouter, Decock, Julie

“…Breast cancer largely dominates the global cancer burden statistics; however, there are striking disparities in mortality rates across countries. While…”
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Deep proteome profiling of human mammary epithelia at lineage and age resolution by Hinz, Stefan, Manousopoulou, Antigoni, Miyano, Masaru, Sayaman, Rosalyn W., Aguilera, Kristina Y., Todhunter, Michael E., Lopez, Jennifer C., Sohn, Lydia L., Wang, Leo D., LaBarge, Mark A.

“…Age is the major risk factor in most carcinomas, yet little is known about how proteomes change with age in any human epithelium. We present comprehensive…”
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Volume-constrained microcontainers enable myoepithelial functional differentiation in highly parallel mammary organoid culture by Todhunter, Michael E., Miyano, Masaru, Moolamalla, Divya S., Filippov, Aleksandr, Sayaman, Rosalyn W., LaBarge, Mark A.

“…A long-standing constraint on organoid culture is the need to add exogenous substances to provide hydrogel matrix, which limits the study of fully human or…”
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Analysis of germline-driven ancestry-associated gene expression in cancers by Chambwe, Nyasha, Sayaman, Rosalyn W., Hu, Donglei, Huntsman, Scott, Carrot-Zhang, Jian, Berger, Ashton C., Han, Seunghun, Meyerson, Matthew, Damrauer, Jeffrey S., Hoadley, Katherine A., Felau, Ina, Demchok, John A., Mensah, Michael K.A., Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Knijnenburg, Theo A., Robertson, A. Gordon, Yau, Christina, Benz, Christopher, Huang, Kuan-lin, Newberg, Justin Y., Frampton, Garrett M., Mashl, R. Jay, Ding, Li, Romanel, Alessandro, Demichelis, Francesca, Zhou, Wanding, Laird, Peter W., Shen, Hui, Wong, Christopher K., Stuart, Joshua M., Lazar, Alexander J., Le, Xiuning, Oak, Ninad, Kemal, Anab, Caesar-Johnson, Samantha, Zenklusen, Jean C., Ziv, Elad, Beroukhim, Rameen, Cherniack, Andrew D.

“…Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to…”
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Comprehensive identification, isolation, and culture of human breast cell types by Thi, Kate, Del Toro, Katelyn, Licon-Munoz, Yamhilette, Sayaman, Rosalyn W., Hines, William C.

“…Tissues are formed and shaped by cells of many different types and are orchestrated through countless interactions. Deciphering a tissue’s biological…”
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Loss of epigenetic suppression of retrotransposons with oncogenic potential in aging mammary luminal epithelial cells by Senapati, Parijat, Miyano, Masaru, Sayaman, Rosalyn W, Basam, Mudaser, Leung, Amy, LaBarge, Mark A, Schones, Dustin E

“…A primary function of DNA methylation in mammalian genomes is to repress transposable elements (TEs). The widespread methylation loss that is commonly observed…”
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Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer by Carrot-Zhang, Jian, Chambwe, Nyasha, Damrauer, Jeffrey S., Knijnenburg, Theo A., Robertson, A. Gordon, Yau, Christina, Zhou, Wanding, Berger, Ashton C., Huang, Kuan-lin, Newberg, Justin Y., Mashl, R. Jay, Romanel, Alessandro, Sayaman, Rosalyn W., Demichelis, Francesca, Felau, Ina, Frampton, Garrett M., Han, Seunghun, Hoadley, Katherine A., Kemal, Anab, Laird, Peter W., Lazar, Alexander J., Le, Xiuning, Oak, Ninad, Shen, Hui, Wong, Christopher K., Zenklusen, Jean C., Ziv, Elad, Aguet, Francois, Ding, Li, Demchok, John A., Mensah, Michael K.A., Caesar-Johnson, Samantha, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Alfoldi, Jessica, Karczewski, Konrad J., MacArthur, Daniel G., Meyerson, Matthew, Benz, Christopher, Stuart, Joshua M., Cherniack, Andrew D., Beroukhim, Rameen

“…We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA expression among 10,678 patients across 33 cancer types from The Cancer…”
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Germline genetic contribution to the immune landscape of cancer by Sayaman, Rosalyn W., Saad, Mohamad, Thorsson, Vésteinn, Hu, Donglei, Hendrickx, Wouter, Roelands, Jessica, Porta-Pardo, Eduard, Mokrab, Younes, Farshidfar, Farshad, Kirchhoff, Tomas, Sweis, Randy F., Bathe, Oliver F., Heimann, Carolina, Campbell, Michael J., Stretch, Cynthia, Huntsman, Scott, Graff, Rebecca E., Syed, Najeeb, Radvanyi, Laszlo, Shelley, Simon, Wolf, Denise, Marincola, Francesco M., Ceccarelli, Michele, Galon, Jérôme, Ziv, Elad, Bedognetti, Davide

“…Understanding the contribution of the host’s genetic background to cancer immunity may lead to improved stratification for immunotherapy and to the…”
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Tissue aging: the integration of collective and variant responses of cells to entropic forces over time by Todhunter, Michael E, Sayaman, Rosalyn W, Miyano, Masaru, LaBarge, Mark A

“…Aging is driven by unavoidable entropic forces, physicochemical in nature, that damage the raw materials that constitute biological systems. Single cells…”
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An integrated tumor, immune and microbiome atlas of colon cancer by Roelands, Jessica, Kuppen, Peter J. K., Ahmed, Eiman I., Mall, Raghvendra, Masoodi, Tariq, Singh, Parul, Monaco, Gianni, Raynaud, Christophe, de Miranda, Noel F.C.C., Ferraro, Luigi, Carneiro-Lobo, Tatiana C., Syed, Najeeb, Rawat, Arun, Awad, Amany, Decock, Julie, Mifsud, William, Miller, Lance D., Sherif, Shimaa, Mohamed, Mahmoud G., Rinchai, Darawan, Van den Eynde, Marc, Sayaman, Rosalyn W., Ziv, Elad, Bertucci, Francois, Petkar, Mahir Abdulla, Lorenz, Stephan, Mathew, Lisa Sara, Wang, Kun, Murugesan, Selvasankar, Chaussabel, Damien, Vahrmeijer, Alexander L., Wang, Ena, Ceccarelli, Anna, Fakhro, Khalid A., Zoppoli, Gabriele, Ballestrero, Alberto, Tollenaar, Rob A.E.M., Marincola, Francesco M., Galon, Jérôme, Khodor, Souhaila Al, Ceccarelli, Michele, Hendrickx, Wouter, Bedognetti, Davide

“…The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this…”
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Clinical significance and biology of circulating tumor DNA in high-risk early-stage HER2-negative breast cancer receiving neoadjuvant chemotherapy by Magbanua, Mark Jesus M., Brown Swigart, Lamorna, Ahmed, Ziad, Sayaman, Rosalyn W., Renner, Derrick, Kalashnikova, Ekaterina, Hirst, Gillian L., Yau, Christina, Wolf, Denise M., Li, Wen, Delson, Amy L., Asare, Smita, Liu, Minetta C., Albain, Kathy, Chien, A. Jo, Forero-Torres, Andres, Isaacs, Claudine, Nanda, Rita, Tripathy, Debu, Rodriguez, Angel, Sethi, Himanshu, Aleshin, Alexey, Rabinowitz, Matthew, Perlmutter, Jane, Symmans, W. Fraser, Yee, Douglas, Hylton, Nola M., Esserman, Laura J., DeMichele, Angela M., Rugo, Hope S., van ’t Veer, Laura J.

“…Circulating tumor DNA (ctDNA) analysis may improve early-stage breast cancer treatment via non-invasive tumor burden assessment. To investigate…”
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Changes in Immune Cell Types with Age in Breast are Consistent with a Decline in Immune Surveillance and Increased Immunosuppression by Zirbes, Arrianna, Joseph, Jesuchristopher, Lopez, Jennifer C., Sayaman, Rosalyn W., Basam, Mudaser, Seewaldt, Victoria L., LaBarge, Mark A.

“…A majority of breast cancers (BC) are age-related and we seek to determine what cellular and molecular changes occur in breast tissue with age that make women…”
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Cell-free DNA Concentration as a Biomarker of Response and Recurrence in HER2-Negative Breast Cancer Receiving Neoadjuvant Chemotherapy by Magbanua, Mark Jesus M, Ahmed, Ziad, Sayaman, Rosalyn W, Brown Swigart, Lamorna, Hirst, Gillian L, Yau, Christina, Wolf, Denise M, Li, Wen, Delson, Amy L, Perlmutter, Jane, Pohlmann, Paula, Symmans, W Fraser, Yee, Douglas, Hylton, Nola M, Esserman, Laura J, DeMichele, Angela M, Rugo, Hope S, van 't Veer, Laura J

“…We previously demonstrated the clinical significance of circulating tumor DNA (ctDNA) in patients with HER2-negative breast cancer receiving neoadjuvant…”
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Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation by Miyano, Masaru, Sayaman, Rosalyn W, Shalabi, Sundus F, Senapati, Parijat, Lopez, Jennifer C, Angarola, Brittany Lynn, Hinz, Stefan, Zirbes, Arrianna, Anczukow, Olga, Yee, Lisa D, Sedrak, Mina S, Stampfer, Martha R, Seewaldt, Victoria L, LaBarge, Mark A

“…A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of , a transcription factor…”
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Ancestry-specific predisposing germline variants in cancer by Oak, Ninad, Cherniack, Andrew D, Mashl, R Jay, Hirsch, Fred R, Ding, Li, Beroukhim, Rameen, Gümüş, Zeynep H, Plon, Sharon E, Huang, Kuan-Lin

“…Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of…”
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Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells by Miyano, Masaru, Sayaman, Rosalyn W, Stoiber, Marcus H, Lin, Chun-Han, Stampfer, Martha R, Brown, James B, LaBarge, Mark A

“…Luminal epithelial cells in the breast gradually alter gene and protein expression with age, appearing to lose lineage-specificity by acquiring…”
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Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations by Shalabi, Sundus F, Miyano, Masaru, Sayaman, Rosalyn W, Lopez, Jennifer C, Jokela, Tiina A, Todhunter, Michael E, Hinz, Stefan, Garbe, James C, Stampfer, Martha R, Kessenbrock, Kai, Seewaldt, Victoria E, LaBarge, Mark A

“…During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed in myoepithelial cells. We…”
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