Search Results - "Saxton, T M"

Signaling Networks—Do All Roads Lead to the Same Genes? by Pawson, Tony, Saxton, Tracy M

“…A significant issue in signal transduction is whether individual biochemical pathways activated in the cytoplasm induce unique, overlapping, or redundant…”
Get full text

The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development by Saxton, Tracy M, Pawson, Tony, Ciruna, Brian G, Holmyard, Doug, Kulkarni, Sarang, Harpal, Ken, Rossant, Janet

“…The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific…”
Get full text

Morphogenetic Movements at Gastrulation Require the SH2 Tyrosine Phosphatase Shp2 by Saxton, Tracy M., Pawson, Tony

“…The SH2 domain-containing tyrosine phosphatase Shp2 plays a pivotal role during the gastrulation of vertebrate embryos. However, because of the complex…”
Get full text

Evidence for a functional subclass of the RTVL-H family of human endogenous retrovirus-like sequences by WILKINSON, D. A, GOODCHILD, N. L, SAXTON, T. M, WOOD, S, MAGER, D. L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2 by Saxton, Tracy M., Henkemeyer, Mark, Gasca, Stephan, Shen, Randy, Rossi, Derrick J., Shalaby, Fouad, Feng, Gen-Sheng, Pawson, Tony

“…Shp‐1, Shp‐2 and corkscrew comprise a small family of cytoplasmic tyrosine phosphatases that possess two tandem SH2 domains. To investigate the biological…”
Get full text

Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System by Henkemeyer, Mark, Orioli, Donata, Henderson, Jeffrey T, Saxton, Tracy M, Roder, John, Pawson, Tony, Klein, Rüdiger

“…Eph family receptor tyrosine kinases have been proposed to control axon guidance and fasciculation. To address the biological functions of the Eph family…”
Get full text

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation by Cheng, Alec M, Saxton, Tracy M, Sakai, Ryuichi, Kulkarni, Sarang, Mbamalu, Geraldine, Vogel, Wolfgang, Tortorice, Christopher G, Cardiff, Robert D, Cross, James C, Muller, William J, Pawson, Tony

“…Proteins with SH2 and SH3 domains link tyrosine kinases to intracellular pathways. To investigate the biological functions of a mammalian SH2/SH3 adaptor, we…”
Get full text

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2 by Oh, Eok-Soo, Gu, Haihua, Saxton, Tracy M., Timms, John F., Hausdorff, Sharon, Frevert, Ernst U., Kahn, Barbara B., Pawson, Tony, Neel, Benjamin G., Thomas, Sheila M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Mammalian ShcB and ShcC Phosphotyrosine Docking Proteins Function in the Maturation of Sensory and Sympathetic Neurons by Sakai, Ryuichi, Henderson, Jeffrey T., O'Bryan, John P., Elia, Andrew J., Saxton, Tracy M., Pawson, Tony

“…Shc proteins possess SH2 and PTB domains and serve a scaffolding function in signaling by a variety of receptor tyrosine kinases. There are three known…”
Get full text

Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis by Saxton, Tracy M, Cheng, Alec M, Ong, Siew Hwa, Lu, Yong, Sakai, Ryuichi, Cross, James C, Pawson, Tony

“…Background: The mammalian Grb2 adaptor protein binds pTyr-X-Asn motifs through its SH2 domain, and engages downstream targets such as Sos1 and Gab1 through its…”
Get full text

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine- phosphorylated protein by Saxton, TM, van Oostveen, I, Bowtell, D, Aebersold, R, Gold, MR

“…Ligation of the B cell AgR activates p21ras (Ras). We have investigated the effects of AgR ligation on three proteins that have been implicated as regulators…”
Get full text

Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes by Gold, MR, Chiu, R, Ingham, RJ, Saxton, TM, van Oostveen, I, Watts, JD, Affolter, M, Aebersold, R

“…We show that cross-linking the B cell AgR with anti-Ig Abs activates p56lck (Lck) in both the immature B cell line WEHI-231 and mature resting B cells from…”
Get full text

Physiological and perceptual responses to upper- and lower-limb aerobic exercise in patients with peripheral arterial disease by Zwierska, I, Male, J S, Choksy, SA, Pockley, A G, Saxton, T M

“…In many patients with peripheral arterial disease, exercise tolerance is severely limited by ischemic pain, when there is an inability of the lower-limb…”
Get full text

B cell antigen receptor cross-linking induces phosphorylation of the p21 super(ras) oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein by Saxton, T M, Van Oostveen, I, Bowtell, D, Aebersold, R, Gold, M R

“…Ligation of the B cell AgR activates p21 super(ras) (Ras). We have investigated the effects of AgR ligation on three proteins that have been implicated as…”
Get full text

Activation and serine phosphorylation of the p56 super(lck) protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes by Gold, M R, Chiu, R, Ingham, R J, Saxton, T M, Van Oostveen, I, Watts, J D, Affolter, M, Aebersold, R

“…We show that cross-linking the B cell AgR with anti-Ig Abs activates p56 super(lck) (Lck) in both the immature B cell line WEHI-231 and mature resting B cells…”
Get full text