Search Results - "Sax, Martin"

Domain Organization in Clostridium botulinum Neurotoxin Type E Is Unique: Its Implication in Faster Translocation by Kumaran, Desigan, Eswaramoorthy, Subramaniam, Furey, William, Navaza, Jorge, Sax, Martin, Swaminathan, Subramanyam

“…Clostridium botulinum produces seven antigenically distinct neurotoxins [C. botulinum neurotoxins (BoNTs) A–G] sharing a significant sequence homology. Based…”
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A Thiamin-bound, Pre-decarboxylation Reaction Intermediate Analogue in the Pyruvate Dehydrogenase E1 Subunit Induces Large Scale Disorder-to-Order Transformations in the Enzyme and Reveals Novel Structural Features in the Covalently Bound Adduct by Arjunan, Palaniappa, Sax, Martin, Brunskill, Andrew, Chandrasekhar, Krishnamoorthy, Nemeria, Natalia, Zhang, Sheng, Jordan, Frank, Furey, William

“…The crystal structure of the E1 component from the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc) has been determined with…”
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Crystal structure of staphylococcal enterotoxin B, a superantigen by Swaminathan, S, Furey, William, Pletcher, James, Sax, Martin

“…The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a super-antigen, has been determined to a resolution of 2.5 A. The…”
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Insight to the Interaction of the Dihydrolipoamide Acetyltransferase (E2) Core with the Peripheral Components in the Escherichia coli Pyruvate Dehydrogenase Complex via Multifaceted Structural Approaches by Chandrasekhar, Krishnamoorthy, Wang, Junjie, Arjunan, Palaniappa, Sax, Martin, Park, Yun-Hee, Nemeria, Natalia S., Kumaran, Sowmini, Song, Jaeyoung, Jordan, Frank, Furey, William

“…Multifaceted structural approaches were undertaken to investigate interaction of the E2 component with E3 and E1 components from the Escherichia coli pyruvate…”
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Structure of the Pyruvate Dehydrogenase Multienzyme Complex E1 Component from Escherichia coli at 1.85 Å Resolution by Arjunan, Palaniappa, Nemeria, Natalia, Brunskill, Andrew, Chandrasekhar, Krishnamoorthy, Sax, Martin, Yan, Jordan, Frank, Guest, John R, Furey, William

“…The crystal structure of the recombinant thiamin diphosphate-dependent E1 component from the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc)…”
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Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-.ANG. resolution by Dyda, Fred, Furey, William, Swaminathan, Subramanyam, Sax, Martin, Farrenkopf, Bruce, Jordan, Frank

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Structural Determinants of Enzyme Binding Affinity:  The E1 Component of Pyruvate Dehydrogenase from Escherichia coli in Complex with the Inhibitor Thiamin Thiazolone Diphosphate by Arjunan, Palaniappa, Chandrasekhar, Krishnamoorthy, Sax, Martin, Brunskill, Andrew, Nemeria, Natalia, Jordan, Frank, Furey, William

“…Thiamin thiazolone diphosphate (ThTDP), a potent inhibitor of the E1 component from the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDHc),…”
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Stereochemistry of intermediates in thiamine catalysis. 2. Crystal structure of DL-2-(.alpha.-hydroxybenzyl)thiamine chloride hydrochloride trihydrate by Pletcher, James, Sax, Martin, Blank, Gary, Wood, Mical

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Ring stacking interactions between thiamin and planar molecules as seen in the crystal structure of a thiamin picrolonate dihydrate complex by Shin, Whanchul, Pletcher, James, Blank, Gary, Sax, Martin

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Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-Å resolution by DYDA, F, FUREY, W, SUBRAMANYAM SWAMINATHAN, SAX, M, FARRENKOPF, B, JORDAN, F

“…The crystal structure of brewers' yeast pyruvate decarboxylase, a thiamin diphosphate dependent alpha-keto acid decarboxylase, has been determined to 2.4-A…”
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Thiamine Pyrophosphate Hydrochloride: Stereochemical Aspects from an X-Ray Diffraction Study by Pletcher, J, Sax, M

“…The crystal structure of thiamine pyrophosphate has been determined by a three-dimensional x-ray analysis. The conformation of the molecule in the crystalline…”
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Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 Å resolution by Arjunan, Palaniappa, Sax, Martin, Nemeria, Natalia, Jordan, Frank, Chandrasekhar, Krishnamoorthy, Furey, William

“…The first enzymatic component, E1 (EC 1.2.4.1), of the pyruvate dehydrogenase multienzyme complex (PDHc) utilizes thiamine diphosphate (ThDP) and Mg2+ as…”
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Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 Aa resolution by Arjunan, Palaniappa, Sax, Martin, Nemeria, Natalia, Jordan, Frank, Chandrasekhar, Krishnamoorthy, Furey, William

“…The first enzymatic component, E1 (EC 1.2.4.1), of the pyruvate dehydrogenase multienzyme complex (PDHc) utilizes thiamine diphosphate (ThDP) and Mg super(2+)…”
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Structure of the receptor binding fragment HC of tetanus neurotoxin by Umland, T C, Wingert, L M, Swaminathan, S, Furey, W F, Schmidt, J J, Sax, M

“…The 2.7 A structure of the tetanus neurotoxin receptor binding fragment Hc reveals a jelly-roll domain and a beta-trefoil domain. Hc retains the unique…”
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Structure of the receptor binding fragment H C of tetanus neurotoxin by Umland, Timothy C, Wingert, Lavinia M, Swaminathan, S, Furey, William F, Schmidt, James J, Sax, Martin

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Crystal Structure of a Bovine Neurophysin II Dipeptide Complex at 2.8 Å Determined from the Single-Wavelength Anomalous Scattering Signal of an Incorporated Iodine Atom by Chen, Liqing, Rose, John P., Breslow, Esther, Yang, Daniel, Chang, Wen-Rui, Furey, William F., Sax, Martin, Wang, Bi-Cheng

“…The crystal structure of a dipeptide complex of bovine neurophysin II has been solved at 2.8 Å resolution solely by using single-wavelength anomalous…”
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Residues defining Vβ specificity in staphylococcal enterotoxins by Swaminathan, S, Furey, William, Pletcher, James, Sax, Martin

“…The three-dimensional structure of staphylococcal enterotoxin C2 has been determined at 2.7 A resolution by x-ray diffraction, while the structures of…”
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Twixt form and function by Umland, Timothy C, Sax, Martin

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Accuracy of secondary structure and solvent accessibility predictions for a clostridial neurotoxin C-fragment by Lebeda, F J, Umland, T C, Sax, M, Olson, M A

“…Earlier studies used Rost and Sander's artificial neural network [(1993a), J. Mol. Biol. 232, 584-599] to predict the secondary structures [Lebeda and Olson…”
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Crystallization and preliminary X-ray analysis of tetanus neurotoxin C fragment by Umland, Timothy C., Wingert, Lavinia, Swaminathan, S., Schmidt, James J., Sax, Martin

“…Two crystal forms of recombinant tetanus neurotoxin C fragment have been obtained. The C fragment corresponds to the C‐terminal 451 amino‐acid residues of…”
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