Search Results - "Sawyer, L"

How host genetics dictates successful viral zoonosis by Warren, Cody J, Sawyer, Sara L

“…Viruses of wild and domestic animals can infect humans in a process called zoonosis, and these events can give rise to explosive epidemics such as those caused…”
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Competition between microtubule-associated proteins directs motor transport by Monroy, Brigette Y., Sawyer, Danielle L., Ackermann, Bryce E., Borden, Melissa M., Tan, Tracy C., Ori-McKenney, Kassandra M.

“…Within cells, motor and non-motor microtubule-associated proteins (MAPs) simultaneously converge on the microtubule. How the binding activities of non-motor…”
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High-throughput DNA sequencing errors are reduced by orders of magnitude using circle sequencing by Lou, Dianne I., Hussmann, Jeffrey A., McBee, Ross M., Acevedo, Ashley, Andino, Raul, Press, William H., Sawyer, Sara L.

“…A major limitation of high-throughput DNA sequencing is the high rate of erroneous base calls produced. For instance, Illumina sequencing machines produce…”
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Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication by Zhang, Junjie, Zhao, Jun, Xu, Simin, Li, Junhua, He, Shanping, Zeng, Yi, Xie, Linshen, Xie, Na, Liu, Ting, Lee, Katie, Seo, Gil Ju, Chen, Lin, Stabell, Alex C., Xia, Zanxian, Sawyer, Sara L., Jung, Jae, Huang, Canhua, Feng, Pinghui

“…Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but some non-human primates exhibit resistance via unknown mechanisms. Innate immune…”
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Identification of a genomic reservoir for new TRIM genes in primate genomes by Han, Kyudong, Lou, Dianne I, Sawyer, Sara L

“…Tripartite Motif (TRIM) ubiquitin ligases act in the innate immune response against viruses. One of the best characterized members of this family, TRIM5α,…”
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Dual host-virus arms races shape an essential housekeeping protein by Demogines, Ann, Abraham, Jonathan, Choe, Hyeryun, Farzan, Michael, Sawyer, Sara L

“…Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also…”
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Invited review: beta-lactoglobulin: binding properties, structure, and function by Kontopidis, G, Holt, C, Sawyer, L

“…beta-Lactoglobulin (beta-LG) is the major whey protein of ruminant species and is also present in the milks of many, but not all, other species. Its amino-acid…”
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Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape by Lu, Chao, Jain, Siddhant U., Hoelper, Dominik, Bechet, Denise, Molden, Rosalynn C., Ran, Leili, Murphy, Devan, Venneti, Sriram, Hameed, Meera, Pawel, Bruce R., Wunder, Jay S., Dickson, Brendan C., Lundgren, Stefan M., Jani, Krupa S., De Jay, Nicolas, Papillon-Cavanagh, Simon, Andrulis, Irene L., Sawyer, Sarah L., Grynspan, David, Turcotte, Robert E., Nadaf, Javad, Fahiminiyah, Somayyeh, Muir, Tom W., Majewski, Jacek, Thompson, Craig B., Chi, Ping, Garcia, Benjamin A., Allis, C. David, Jabado, Nada, Lewis, Peter W.

“…Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly…”
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Two-stepping through time: mammals and viruses by Meyerson, Nicholas R, Sawyer, Sara L

“…Recent studies have identified ancient virus genomes preserved as fossils within diverse animal genomes. These fossils have led to the revelation that a broad…”
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Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation by Meyerson, Nicholas R., Zhou, Ligang, Guo, Yusong R., Zhao, Chen, Tao, Yizhi J., Krug, Robert M., Sawyer, Sara L.

“…TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response. The NS1 protein from all strains of influenza A virus binds…”
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Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins by Stabell, Alex C, Hawkins, John, Li, Manqing, Gao, Xia, David, Michael, Press, William H, Sawyer, Sara L

“…Schlafen11 (encoded by the SLFN11 gene) has been shown to inhibit the accumulation of HIV-1 proteins. We show that the SLFN11 gene is under positive selection…”
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Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype by Sawyer, Sarah L, Tian, Lei, Kähkönen, Marketta, Schwartzentruber, Jeremy, Kircher, Martin, Majewski, Jacek, Dyment, David A, Innes, A Micheil, Boycott, Kym M, Moreau, Lisa A, Moilanen, Jukka S, Greenberg, Roger A

“…Deficiency in BRCA-dependent DNA interstrand crosslink (ICL) repair is intimately connected to breast cancer susceptibility and to the rare developmental…”
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Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin by McDonell, Laura M, Kernohan, Kristin D, Boycott, Kym M, Sawyer, Sarah L

“…Receptor tyrosine kinases (RTKs) are a family of ligand-binding cell surface receptors that regulate a wide range of essential cellular activities, including…”
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Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats by DEMOGINES, Ann, FARZAN, Michael, SAWYER, Sara L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus by Burke, James M, Ripin, Nina, Ferretti, Max B, St Clair, Laura A, Worden-Sapper, Emma R, Salgado, Fernando, Sawyer, Sara L, Perera, Rushika, Lynch, Kristen W, Parker, Roy

“…The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune response to destroy host and viral RNA to ultimately reduce viral gene…”
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Long‐term efficacy of novel therapies in moderate‐to‐severe plaque psoriasis: a systematic review and network meta‐analysis of PASI response by Sawyer, L.M., Cornic, L., Levin, L.Å., Gibbons, C., Møller, A.H., Jemec, G.B.

“…Background Patients with moderate‐to‐severe psoriasis require long‐term treatment, yet few trials compare outcomes beyond a short‐term induction period…”
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Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G by Sawyer, Sara L, Emerman, Michael, Malik, Harmit S

“…Host genomes have adopted several strategies to curb the proliferation of transposable elements and viruses. A recently discovered novel primate defense…”
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How avian influenza viruses spill over to mammals by Barbachano-Guerrero, Arturo, Perez, Daniel R, Sawyer, Sara L

“…The H3N2 canine influenza virus - which originally came from birds - is evolving to become more transmissible between dogs…”
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RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses by Mamgain, Asha, Sawyer, India L, Timajo, David A M, Rizwan, Mohammed Z, Evans, Maggie C, Ancel, Caroline M, Inglis, Megan A, Anderson, Greg M

“…RF-amide related peptide 3 (RFRP-3) is a neuropeptide thought to inhibit central regulation of fertility. We investigated whether alterations in RFRP neuronal…”
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Positive Selection of Primate TRIM5α Identifies a Critical Species-Specific Retroviral Restriction Domain by Sawyer, Sara L., Wu, Lily I., Emerman, Michael, Malik, Harmit S., Groudine, Mark T.

“…Primate genomes encode a variety of innate immune strategies to defend themselves against retroviruses. One of these, TRIM5α, can restrict diverse retroviruses…”
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