Search Results - "Sawyer, Jessica K."
-
1
Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration
Published in Cell (22-05-2014)“…E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of individual cells on matrix. However, its contribution to migration of…”
Get full text
Journal Article -
2
Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction
Published in The Journal of cell biology (13-07-2009)“…Cadherin-based adherens junctions (AJs) mediate cell adhesion and regulate cell shape change. The nectin-afadin complex also localizes to AJs and links to the…”
Get full text
Journal Article -
3
Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation
Published in Nature communications (20-06-2024)“…Regulation of codon optimality is an increasingly appreciated layer of cell- and tissue-specific protein expression control. Here, we use codon-modified…”
Get full text
Journal Article -
4
A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension
Published in Molecular biology of the cell (15-07-2011)“…Integrating individual cell movements to create tissue-level shape change is essential to building an animal. We explored mechanisms of adherens junction…”
Get full text
Journal Article -
5
Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut
Published in eLife (17-08-2018)“…Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue…”
Get full text
Journal Article -
6
Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm
Published in PloS one (28-10-2009)“…Tissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this…”
Get full text
Journal Article -
7
Distinct responses to rare codons in select Drosophila tissues
Published in eLife (06-05-2022)“…Codon usage bias has long been appreciated to influence protein production. Yet, relatively few studies have analyzed the impacts of codon usage on…”
Get full text
Journal Article -
8
Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo
Published in PLoS genetics (09-12-2020)“…Signal transduction pathways are intricately fine-tuned to accomplish diverse biological processes. An example is the conserved…”
Get full text
Journal Article -
9
Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut
Published in Developmental cell (26-07-2021)“…Individual organ development must be temporally coordinated with development of the rest of the organism. As a result, cell division cycles in a developing…”
Get full text
Journal Article -
10
Physiology, Development, and Disease Modeling in the Drosophila Excretory System
Published in Genetics (Austin) (01-02-2020)“…Abstract The insect excretory system contains two organ systems acting in concert: the Malpighian tubules and the hindgut perform essential roles in excretion…”
Get full text
Journal Article -
11
Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone
Published in Development (Cambridge) (15-11-2017)“…The molecular identities and regulation of cells at interorgan boundaries are often unclear, despite the increasingly appreciated role of organ boundaries in…”
Get full text
Journal Article -
12
How the Cytoskeleton Helps Build the Embryonic Body Plan: Models of Morphogenesis from Drosophila
Published in Current topics in developmental biology (2009)“…One key challenge for cell and developmental biologists is to determine how the cytoskeletal toolkit is used to build embryonic tissues and organs. Here, we…”
Get full text
Book Chapter Journal Article -
13
Morphogenesis: Multitalented GTPases Seeking New Jobs
Published in Current biology (17-11-2009)“…Since their discovery twenty years ago the GTPases Rac, Rho, and Cdc42 have become cellular superstars, with diverse roles in regulating actin, cell polarity…”
Get full text
Journal Article -
14
Inter-organ regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone
Published in Development (Cambridge) (01-01-2017)“…The molecular identities and regulation of cells at inter-organ boundaries are often unclear, despite the increasingly appreciated role of organ boundaries in…”
Get full text
Journal Article -
15
Physiology, Development, and Disease Modeling in the Drosophila Excretory System
Published in Genetics (Austin) (01-02-2020)“…The insect excretory system contains two organ systems acting in concert: the Malpighian tubules and the hindgut perform essential roles in excretion and ionic…”
Get full text
Journal Article -
16
Chapter 3 How the Cytoskeleton Helps Build the Embryonic Body Plan
Published in Current Topics in Developmental Biology (2009)“…One key challenge for cell and developmental biologists is to determine how the cytoskeletal toolkit is used to build embryonic tissues and organs. Here, we…”
Get full text
Book Chapter -
17
The role of Canoe/Afadin in Drosophila morphogenesis
Published 01-01-2010“…Morphogenesis is the amazing process of forming tissues and organs to build an animal. Coordinating cell-cell adhesion and cell shape change are both essential…”
Get full text
Dissertation -
18
The role of Canoe/Afadin in Drosophila morphogenesis
Get full text
Dissertation