Search Results - "Sawyer, Jeffrey R"

The prognostic significance of cytogenetics and molecular profiling in multiple myeloma by Sawyer, Jeffrey R

“…Multiple myeloma (MM) is a plasma cell malignancy characterized by very complex cytogenetic and molecular genetic aberrations. In newly diagnosed symptomatic…”
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Epidemiology of Pediatric Fractures Presenting to Emergency Departments in the United States by Naranje, Sameer M, Erali, Richard A, Warner, William C, Sawyer, Jeffrey R, Kelly, Derek M

“…BACKGROUND:Fractures in children are an important public health issue and a frequent cause of emergency room visits. The purpose of this descriptive…”
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Outcomes and Complications of Tibial Tubercle Fractures in Pediatric Patients: A Systematic Review of the Literature by Pretell-Mazzini, Juan, Kelly, Derek M, Sawyer, Jeffrey R, Esteban, Eva M.A, Spence, David D, Warner, William C, Beaty, James H

“…BACKGROUND:Systematic review of the literature was done to determine (1) the frequency and type of associated injuries, (2) frequency of concomitant…”
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Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation by Hanamura, Ichiro, Stewart, James P., Huang, Yongsheng, Zhan, Fenghuang, Santra, Madhumita, Sawyer, Jeffrey R., Hollmig, Klaus, Zangarri, Maurizio, Pineda-Roman, Mauricio, van Rhee, Frits, Cavallo, Federica, Burington, Bart, Crowley, John, Tricot, Guido, Barlogie, Bart, Shaughnessy, John D.

“…Using fluorescence in situ hybridization we investigated amplification of chromosome band 1q21 (Amp1q21) in more than 500 untreated patients with monoclonal…”
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MRI Safety with Orthopedic Implants by Mosher, Zachary A., MD, Sawyer, Jeffrey R., MD, Kelly, Derek M., MD

“…The literature within the last 10 years on MRI use in patients with orthopedic implants is reviewed. A literature search returned 15 relevant articles. Only 2…”
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A Systematic Approach to the Evaluation of a Limping Child by Naranje, Sameer, MD, Kelly, Derek M., MD, Sawyer, Jeffrey R., MD

“…A limp is defined as a deviation from a normal age-appropriate gait pattern resulting in an uneven, jerky, or laborious gait. It can be caused by pain,…”
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Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease by Sawyer, Jeffrey R., Tian, Erming, Heuck, Christoph J., Epstein, Joshua, Johann, Donald J., Swanson, Charles M., Lukacs, Janet L., Johnson, Marian, Binz, Regina, Boast, Angela, Sammartino, Gael, Usmani, Saad, Zangari, Maurizio, Waheed, Sarah, van Rhee, Frits, Barlogie, Bart

“…Multiple myeloma (MM) is a B-cell malignancy driven in part by increasing copy number alterations (CNAs) during disease progression. Prognostically significant…”
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The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage by Pathak, Rupak, Bachri, Abdel, Ghosh, Sanchita P., Koturbash, Igor, Boerma, Marjan, Binz, Regina K., Sawyer, Jeffrey R., Hauer-Jensen, Martin

“…Purpose Ionizing radiation (IR) generates reactive oxygen species (ROS), which cause DNA double-strand breaks (DSBs) that are responsible for cytogenetic…”
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Changes in the Treatment of Pediatric Femoral Fractures: 15-Year Trends From United States Kids’ Inpatient Database (KID) 1997 to 2012 by Naranje, Sameer M, Stewart, Matthew G, Kelly, Derek M, Jones, Tamekia L, Spence, David D, Warner, William C, Beaty, James H, Sawyer, Jeffrey R

“…BACKGROUND:The options for treating femoral fractures in children and adolescents have evolved over the last 2 decades to include a variety of nonoperative and…”
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The Limping Child: A Systematic Approach to Diagnosis by Sawyer, Jeffrey R., MD, Kapoor, Mukesh, MD

“…Deviations from a normal age-appropriate gait pattern can be caused by a wide variety of conditions. In most children, limping is caused by a mild,…”
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Use of Magnetic Resonance Imaging in the Evaluation of Spondylolysis by Rush, Jeremy K, Astur, Nelson, Scott, Stephanie, Kelly, Derek M, Sawyer, Jeffrey R, Warner, William C

“…BACKGROUND:In early studies, magnetic resonance imaging (MRI) had low sensitivity and positive predictive value in the evaluation of the pars interarticularis…”
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Complications After Surgical Treatment of Adolescent Idiopathic Scoliosis by de Mendonça, Rodrigo Góes Medéa, MD, Sawyer, Jeffrey R., MD, Kelly, Derek M., MD

“…Even with current techniques and instrumentation, complications can occur after operative treatment of adolescent idiopathic scoliosis. The most dreaded…”
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Malignant progression in meningioma: documentation of a series and analysis of cytogenetic findings by AL-MEFTY, Ossama, KADRI, Paulo A. S, PRAVDENKOVA, Svetlana, SAWYER, Jeffrey R, STANGEBY, Colin, HUSAIN, Muhammad

“…The malignant progression of benign tumors is well documented in gliomas and other systemic lesions. It is also well known that some meningiomas become…”
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Radiation-induced meningiomas: clinical, pathological, cytokinetic, and cytogenetic characteristics by AL-MEFTY, Ossama, TOPSAKAL, Cahide, PRAVDENKOVA, Svetlana, SAWYER, Jeffrey R, HARRISON, Michael J

“…Radiation-induced meningiomas are known to occur after high- and low-dose cranial radiation therapy. The goal of this study was to discern the distinguishing…”
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Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors by Gabrea, Ana, Martelli, Maria Luisa, Qi, Ying, Roschke, Anna, Barlogie, Bart, Shaughnessy Jr, John D., Sawyer, Jeffrey R., Kuehl, W. Michael

“…The pathogenesis of multiple myeloma (MM) is thought to involve at least two pathways, which generate hyperdiploid (HRD) or nonhyperdiploid (NHRD) tumors,…”
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Radiation Reduction Strategies in Pediatric Orthopaedics by Sawyer, Jeffrey R.

“…Introduction: Pediatric orthopaedic patients have the potential for significant radiation exposure from the use of imaging studies, such as computed tomography…”
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Evidence for a novel mechanism for gene amplification in multiple myeloma: 1q12 pericentromeric heterochromatin mediates breakage‐fusion‐bridge cycles of a 1q12∼23 amplicon by Sawyer, Jeffrey R., Tian, Erming, Thomas, Edward, Koller, Mark, Stangeby, Colin, Sammartino, Gael, Goosen, Linda, Swanson, Charles, Binz, Regina L., Barlogie, Bart, Shaughnessy, John

“…Summary Gene amplification is defined as a copy number (CN) increase in a restricted region of a chromosome arm, and is a mechanism for acquired drug…”
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Complications and Radiographic Outcomes of Posterior Spinal Fusion and Observation in Patients Who Have Undergone Distraction-Based Treatment for Early Onset Scoliosis by Sawyer, Jeffrey R, de Mendonça, Rodrigo Góes Medéa, Flynn, Tara S, Samdani, Amer F, El-Hawary, Ron, Spurway, Alan J, Smith, John T, Emans, John B, St Hilaire, Tricia A, Soufleris, Stephen J, Murphy, Ryan P

“…Retrospective, multicenter. To compare surgical and radiographic outcomes of early-onset scoliosis (EOS) patients who had stopped lengthening for ≥2 years…”
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Daratumumab in high‐risk relapsed/refractory multiple myeloma patients: adverse effect of chromosome 1q21 gain/amplification and GEP70 status on outcome by Mohan, Meera, Weinhold, Niels, Schinke, Carolina, Thanedrarajan, Sharmilan, Rasche, Leo, Sawyer, Jeffrey R., Tian, Erming, Rhee, Frits, Zangari, Maurizio

“…Summary Gain of chromosome 1q21 and the gene expression‐based GEP70 risk score are established prognostic markers for newly diagnosed Multiple Myeloma (MM)…”
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Genomic instability in multiple myeloma: Evidence for jumping segmental duplications of chromosome arm 1q by Sawyer, Jeffrey R., Tricot, Guido, Lukacs, Janet L., Binz, Regina Lichti, Tian, Erming, Barlogie, Bart, Shaughnessy Jr, John

“…Multiple myeloma (MM) is a malignant plasma cell disorder characterized by complex karyotypes and chromosome 1 instability at the cytogenetic level. Chromosome…”
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