Search Results - "Sawyer, James R"

Regiodivergent Ligand-Controlled Rhodium-Catalyzed [(2+2)+2] Carbocyclization Reactions with Alkyl Substituted Methyl Propiolates by Evans, P. Andrew, Sawyer, James R, Inglesby, Phillip A

“…Choice is yours: In the title reaction the selective formation of either regioisomer can be controlled through judicious choice of the ancillary ligands (see…”
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Mechanistic Insight into the Diastereoselective Rhodium-Catalyzed Pauson-Khand Reaction: Role of Coordination Number in Stereocontrol by Wang, Huijun, Sawyer, James R, Evans, P. Andrew, Baik, Mu-Hyun

“…How much CO? Theoretical analysis of the origin of diastereocontrol in the rhodium‐catalyzed Pauson–Khand reaction (see scheme) provides two mechanistic…”
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Enantioselective Synthesis of a γ‑Secretase Modulator via Vinylogous Dynamic Kinetic Resolution by Strotman, Neil A, Ramirez, Antonio, Simmons, Eric M, Soltani, Omid, Parsons, Andrew T, Fan, Yu, Sawyer, James R, Rosner, Thorsten, Janey, Jacob M, Tran, Kristy, Li, Jun, La Cruz, Thomas E, Pathirana, Charles, Ng, Alicia T, Deerberg, Joerg

“…Two efficient asymmetric routes to γ-secretase modulator BMS-932481, under investigation for Alzheimer’s disease, have been developed. The key step for the…”
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Computationally Designed and Experimentally Confirmed Diastereoselective Rhodium-Catalyzed Pauson−Khand Reaction at Room Temperature by Baik, Mu-Hyun, Mazumder, Shivnath, Ricci, Paolo, Sawyer, James R, Song, Ye-Geun, Wang, Huijun, Evans, P. Andrew

“…The computational analysis of the rhodium-catalyzed Pauson−Khand reaction indicates that the key transition state is highly charge-polarized, wherein different…”
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Regio- and Enantioselective Intermolecular Rhodium-Catalyzed [2+2+2] Carbocyclization Reactions of 1,6-Enynes with Methyl Arylpropiolates by Evans, P. Andrew, Lai, Kwong Wah, Sawyer, James R

“…Transition metal-catalyzed [m+n+o] carbocyclization reactions provide powerful methods for the construction of complex polycyclic systems that are generally…”
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Synthetic approaches to a chiral 4-amino-3-hydroxy piperidine with pharmaceutical relevance by Ortiz, Adrian, Young, Ian S, Sawyer, James R, Hsiao, Yi, Singh, Amarjit, Sugiyama, Masano, Corbett, R Michael, Chau, Melissa, Shi, Zhongping, Conlon, David A

“…Four synthetic strategies were evaluated towards the preparation of (-)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol (1), which was constructed with control…”
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Selection and Scale-Up Evaluation of an Alternative Route to (−)-(3R,4R)‑1-Benzyl-4-(benzylamino)piperidin-3-ol by Young, Ian S, Ortiz, Adrian, Sawyer, James R, Conlon, David A, Buono, Frederic G, Leung, Simon W, Burt, Justin L, Sortore, Eric W

“…An efficient, scalable synthesis of (−)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol (4) is described. Reduction of the pyridinium salt prepared from…”
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Intermolecular rhodium-catalyzed [2+2+2] carbocyclization reactions of 1,6-enynes with symmetrical and unsymmetrical alkynes by Evans, P Andrew, Sawyer, James R, Lai, Kwong Wah, Huffman, John C

“…The crossed intermolecular rhodium-catalyzed [2+2+2] carbocyclization of carbon and heteroatom tethered 1,6-enynes can be accomplished with symmetrical and…”
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How to avoid having to run - hide - fight by Sawyer, James R

“…"Zero incidents" is the goal every security planner should work to achieve. The tools to build a "zero incidents" environment involve: * Acknowledging that…”
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Suicide prevention in healthcare by Sawyer, James R

“…Healthcare facilities as growing venues for suicide by patients, family members, and others is a challenge which cannot be ignored by security and safety…”
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New metal-catalyzed carbocyclization reactions for the construction of complex natural products by Evans, P. Andrew, Baum, Erich W., Fazal, Aleem N., Lai, Kwong Wah, Robinson, John E., Sawyer, James R.

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Hospitals and terrorism: the realities; the future; mitigating risks by Sawyer, James R

“…Terrorist acts near hospitals and actual attacks on hospitals have become frequent in other countries and should not be ignored by security planners in this…”
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Preventing hospital gun violence: best practices for security professionals to review and adopt by Sawyer, James R

“…Maintaining a safe, violence-free and therapeutic work place will become the greatest challenge for hospital security professionals, the author predicts,…”
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Regio- and Enantioselective Inter molecular Rhodium-Catalyzed [2+2+2] Carbocyclization Reactions of 1,6-Enynes with Methyl Arylpropiolates by Evans, P. Andrew, Lai, Kwong Wah, Sawyer, James R.

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Regiodivergent Ligand-Controlled Rhodium-Catalyzed [(2+2)+2] Carbocyclization Reactions with Alkyl Substituted Methyl Propiolates by Evans, P. Andrew, Sawyer, James R., Inglesby, Phillip A.

“…Man hat die Wahl: In der Titelreaktion lässt sich die selektive Bildung der zwei Regioisomere durch sorgfältige Wahl der Hilfsliganden steuern (siehe Schema)…”
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Rhodium-catalyzed carbocyclization reactions for the synthesis of five- and six-membered rings by Sawyer, James R

“…Transition metal-catalyzed carbocyclization reactions are a powerful class of transformations that provide a selective and expeditious means of synthesizing…”
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Mechanistic Insight into the Diastereoselective Rhodium-Catalyzed Pauson-Khand Reaction: Role of Coordination Number in Stereocontrol by Wang, Huijun, Sawyer, James R., Evans, P. Andrew, Baik, Mu-Hyun

“…Wieviel CO? Eine theoretische Studie zum Ursprung der Diastereoselektivität bei der rhodiumkatalysierten Pauson‐Khand‐Reaktion (siehe Schema) lieferte zwei…”
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Rhodium-catalyzed carbocyclization reactions for the synthesis of five- and six-membered rings by Sawyer, James R

“…Transition metal-catalyzed carbocyclization reactions are a powerful class of transformations that provide a selective and expeditious means of synthesizing…”
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Regiodivergent Ligand‐Controlled Rhodium‐Catalyzed [(2+2)+2] Carbocyclization Reactions with Alkyl Substituted Methyl Propiolates by Evans, P. Andrew, Sawyer, James R., Inglesby, Phillip A.

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