Search Results - "Sawyer, Douglas B."

Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease by Geissler, Andrew, Ryzhov, Sergey, Sawyer, Douglas B

“…Neuregulins (NRGs) are protein ligands that act through ErbB receptor tyrosine kinases to regulate tissue morphogenesis, plasticity, and adaptive responses to…”
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Neuregulin in Cardiovascular Development and Disease by Odiete, Oghenerukevwe, Hill, Michael F, Sawyer, Douglas B

“…Studies in genetically modified mice have demonstrated that neuregulin-1 (NRG-1), along with the erythroblastic leukemia viral oncogene homolog (ErbB) 2, 3,…”
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Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling by Kivelä, Riikka, Hemanthakumar, Karthik Amudhala, Vaparanta, Katri, Robciuc, Marius, Izumiya, Yasuhiro, Kidoya, Hiroyasu, Takakura, Nobuyuki, Peng, Xuyang, Sawyer, Douglas B, Elenius, Klaus, Walsh, Kenneth, Alitalo, Kari

“…BACKGROUND:Heart failure, which is a major global health problem, is often preceded by pathological cardiac hypertrophy. The expansion of the cardiac…”
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Oxidative Stress in Heart Failure: What Are We Missing? by Sawyer, Douglas B., MD, PhD

“…Abstract Over the past several decades, investigations in humans and animal models of heart failure (HF) have provided substantial evidence that oxidative…”
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Anthracycline Cardiotoxicity: From Bench to Bedside by GIANNI, Luca, HERMAN, Eugene H, LIPSHULTZ, Steven E, MINOTTI, Giorgio, SARVAZYAN, Narine, SAWYER, Douglas B

“…Anthracyclines remain among the most widely prescribed and effective anticancer agents. Unfortunately, life-threatening cardiotoxicity continues to compromise…”
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Mechanisms of Anthracycline Cardiac Injury: Can We Identify Strategies for Cardioprotection? by Sawyer, Douglas B, Peng, Xuyang, Chen, Billy, Pentassuglia, Laura, Lim, Chee Chew

“…Abstract Anthracycline antibiotics have saved the lives of many cancer victims in the 50 plus years since their discovery. A major limitation of their use is…”
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3D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids by Beauchamp, Philippe, Jackson, Christopher B, Ozhathil, Lijo Cherian, Agarkova, Irina, Galindo, Cristi L, Sawyer, Douglas B, Suter, Thomas M, Zuppinger, Christian

“…Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac development, function, and remodeling. Properties of 3D co-cultures are…”
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Heat shock proteins in cancer: chaperones of tumorigenesis by Calderwood, Stuart K., Khaleque, Md Abdul, Sawyer, Douglas B., Ciocca, Daniel R.

“…The heat shock proteins (HSPs) induced by cell stress are expressed at high levels in a wide range of tumors and are closely associated with a poor prognosis…”
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ErbB/integrin signaling interactions in regulation of myocardial cell–cell and cell–matrix interactions by Pentassuglia, Laura, Sawyer, Douglas B.

“…Neuregulin (Nrg)/ErbB and integrin signaling pathways are critical for the normal function of the embryonic and adult heart. Both systems activate several…”
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Heart Transplant Survival Outcomes for Adriamycin-Dilated Cardiomyopathy by Lenneman, Andrew J., MD, Wang, Li, MS, Wigger, Mark, MD, Frangoul, Haydar, MD, Harrell, Frank E., PhD, Silverstein, Cheri, MD, Sawyer, Douglas B., MD, PhD, Lenneman, Carrie G., MD, MSCI

“…In 2015, there will be an estimated 11.3 million cancer survivors. With an increasing population of cancer survivors, it is imperative to understand the…”
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Vascular Endothelial Growth Factor Blockade Promotes the Transition From Compensatory Cardiac Hypertrophy to Failure in Response to Pressure Overload by Izumiya, Yasuhiro, Shiojima, Ichiro, Sato, Kaori, Sawyer, Douglas B, Colucci, Wilson S, Walsh, Kenneth

“…Cardiac hypertrophy is associated with upregulation of vascular endothelial growth factor (VEGF) in the myocardium. Here, we evaluated the effects of a decoy…”
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Circulating growth factors and cardiac remodeling in the community: The Framingham Heart Study by Castro-Diehl, Cecilia, Song, Rebecca J., Sawyer, Douglas B., Wollert, Kai C., Mitchell, Gary F., Cheng, Susan, Vasan, Ramachandran S., Xanthakis, Vanessa

“…Cardiac and vascular growth factors (GF) may influence myocardial remodeling through cardiac growth and angiogenic effects. We hypothesized that concentrations…”
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Disruption of a GATA4/Ankrd1 signaling axis in cardiomyocytes leads to sarcomere disarray: implications for anthracycline cardiomyopathy by Chen, Billy, Zhong, Lin, Roush, Sarah F, Pentassuglia, Laura, Peng, Xuyang, Samaras, Susan, Davidson, Jeffrey M, Sawyer, Douglas B, Lim, Chee Chew

“…Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread…”
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Circulating vascular endothelial growth factor and the risk of cardiovascular events by Kaess, Bernhard M, Preis, Sarah R, Beiser, Alexa, Sawyer, Douglas B, Chen, Tai C, Seshadri, Sudha, Vasan, Ramachandran S

“…To investigate the relation of circulating concentrations of vascular endothelial growth factor (VEGF) for the risk of developing cardiovascular disease (CVD)…”
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Anthracyclines and Heart Failure by Sawyer, Douglas B

“…Doxorubicin and other anthracyclines are used to treat cancer, yet they elevate the risk of heart failure. A recent study provides insight into how doxorubicin…”
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What is Quality End-of-Life Care for Patients With Heart Failure? A Qualitative Study With Physicians by Hutchinson, Rebecca N, Gutheil, Caitlin, Wessler, Benjamin S, Prevatt, Hayley, Sawyer, Douglas B, Han, Paul K J

“…Background Advanced heart failure (AHF) carries a morbidity and mortality that are similar or worse than many advanced cancers. Despite this, there are no…”
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Neuregulin (NRG-1β) Is Pro-Myogenic and Anti-Cachectic in Respiratory Muscles of Post-Myocardial Infarcted Swine by Galindo, Cristi L, Nguyen, Van Thuan, Hill, Braxton, Easterday, Ethan, Cleator, John H, Sawyer, Douglas B

“…Neuregulin-1β (NRG-1β) is a growth and differentiation factor with pleiotropic systemic effects. Because NRG-1β has therapeutic potential for heart failure and…”
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DEspRhigh neutrophils are associated with critical illness in COVID-19 by deKay, Joanne T., Emery, Ivette F., Rud, Jonathan, Eldridge, Ashley, Lord, Christine, Gagnon, David J., May, Teresa L., Herrera, Victoria L. M., Ruiz-Opazo, Nelson, Riker, Richard R., Sawyer, Douglas B., Ryzhov, Sergey, Seder, David B.

“…SARS-CoV-2 infection results in a spectrum of outcomes from no symptoms to widely varying degrees of illness to death. A better understanding of the immune…”
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Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment by Lenneman, Carrie G, Sawyer, Douglas B

“…Through the success of basic and disease-specific research, cancer survivors are one of the largest growing subsets of individuals accessing the healthcare…”
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The Vascular Marker Soluble Fms-Like Tyrosine Kinase 1 Is Associated With Disease Severity and Adverse Outcomes in Chronic Heart Failure by Ky, Bonnie, MD, MSCE, French, Benjamin, PhD, Ruparel, Kosha, MS, Sweitzer, Nancy K., MD, PhD, Fang, James C., MD, Levy, Wayne C., MD, Sawyer, Douglas B., MD, PhD, Cappola, Thomas P., MD, ScM

“…Objectives We sought to evaluate placental growth factor (PlGF) and soluble Fms-like tyrosine kinase 1 (sFlt-1) as clinical biomarkers in chronic heart failure…”
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