Search Results - "Sawyer, Andrew W."

High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase by Ditzler, Mark A, Lange, Margaret J, Bose, Debojit, Bottoms, Christopher A, Virkler, Katherine F, Sawyer, Andrew W, Whatley, Angela S, Spollen, William, Givan, Scott A, Burke, Donald H

“…Systematic evolution of ligands through exponential enrichment (SELEX) is a well-established method for generating nucleic acid populations that are enriched…”
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Poly-Target Selection Identifies Broad-Spectrum RNA Aptamers by Alam, Khalid K., Chang, Jonathan L., Lange, Margaret J., Nguyen, Phuong D.M., Sawyer, Andrew W., Burke, Donald H.

“…Aptamer selections often yield distinct subpopulations, each with unique phenotypes that can be leveraged for specialized applications. Although most…”
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Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, “UCAA-motif” RNA Aptamers by Whatley, Angela S, Ditzler, Mark A, Lange, Margaret J, Biondi, Elisa, Sawyer, Andrew W, Chang, Jonathan L, Franken, Joshua D, Burke, Donald H

“…RNA aptamers that bind the reverse transcriptase (RT) of human immunodeficiency virus (HIV) compete with nucleic acid primer/template for access to RT, inhibit…”
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Lewis acid catalysis of phosphoryl transfer from a copper(II)-NTP complex in a kinase ribozyme by Biondi, Elisa, Poudyal, Raghav R, Forgy, Joshua C, Sawyer, Andrew W, Maxwell, Adam W R, Burke, Donald H

“…The chemical strategies used by ribozymes to enhance reaction rates are revealed in part from their metal ion and pH requirements. We find that kinase ribozyme…”
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