Search Results - "Sawitzki, B"

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children by Loske, J., Röhmel, J., Lukassen, S., Stricker, S., Magalhães, V. G., Liebig, J., Chua, R. L., Thürmann, L., Messingschlager, M., Seegebarth, A., Timmermann, B., Klages, S., Ralser, M., Sawitzki, B., Sander, L. E., Corman, V. M., Conrad, C., Laudi, S., Binder, M., Trump, S., Eils, R., Mall, M. A., Lehmann, I.

“…Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection rates and a substantially lower risk for developing severe…”
Get full text

Liver Transplant Patients With Operational Tolerance: What Can the Graft Itself Tell Us? by Sawitzki, B.

“…This editorial discusses the findings presented by Taubert and colleagues (page 1285) on longitudinal portal tract expansion and infiltration of Foxp3+…”
Get full text

Immune monitoring as prerequisite for transplantation tolerance trials by Behnam Sani, K., Sawitzki, B.

“…Summary Ever since its first application in clinical medicine, scientists have been urged to induce tolerance towards foreign allogeneic transplants and thus…”
Get full text

Abdominal Wall Transplantation: Skin as a Sentinel Marker for Rejection by Gerlach, U. A., Vrakas, G., Sawitzki, B., Macedo, R., Reddy, S., Friend, P. J., Giele, H., Vaidya, A.

“…Abdominal wall transplantation (AWTX) has revolutionized difficult abdominal closure after intestinal transplantation (ITX). More important, the skin of the…”
Get full text

Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi by Bacher, P, Kniemeyer, O, Schönbrunn, A, Sawitzki, B, Assenmacher, M, Rietschel, E, Steinbach, A, Cornely, O A, Brakhage, A A, Thiel, A, Scheffold, A

“…Foxp3 + regulatory T cells (Treg) have a central role for keeping the balance between pro- and anti-inflammatory immune responses against chronically…”
Get full text

Hepatocyte Transplantation to the Liver via the Splenic Artery in a Juvenile Large Animal Model by Siefert, J., Hillebrandt, K. H., Moosburner, S., Podrabsky, P., Geisel, D., Denecke, T., Unger, J. K., Sawitzki, B., Gül-Klein, S., Lippert, S., Tang, P., Reutzel-Selke, A., Morgul, M. H., Reske, A. W., Kafert-Kasting, S., Rüdinger, W., Oetvoes, J., Pratschke, J., Sauer, I. M., Raschzok, N.

“…Hepatocyte transplantation (HcTx) is a promising approach for the treatment of metabolic diseases in newborns and children. The most common application route…”
Get full text

Induction of Allograft Tolerance by Monoclonal CD3 Antibodies: A Matter of Timing by You, S., Zuber, J., Kuhn, C., Baas, M., Valette, F., Sauvaget, V., Sarnacki, S., Sawitzki, B., Bach, J.‐F., Volk, H.‐D., Chatenoud, L.

“…Despite remarkable progress in organ transplantation through the development of a wealth of immunosuppressive drugs highly effective at controlling acute…”
Get full text

Human CD45RA(-) FoxP3(hi) Memory-Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation by Lei, H, Kuchenbecker, L, Streitz, M, Sawitzki, B, Vogt, K, Landwehr-Kenzel, S, Millward, J, Juelke, K, Babel, N, Neumann, A, Reinke, P, Volk, H-D

“…Adoptive immunotherapy with regulatory T cells (Treg) is a new option to promote immune tolerance following solid organ transplantation (SOT). However, Treg…”
Get full text

Molecular Characterization of Acute Cellular Rejection Occurring During Intentional Immunosuppression Withdrawal in Liver Transplantation by Bonaccorsi-Riani, E., Pennycuick, A., Londoño, M.-C., Lozano, J.-J., Benítez, C., Sawitzki, B., Martínez-Picola, M., Bohne, F., Martínez-Llordella, M., Miquel, R., Rimola, A., Sánchez-Fueyo, A.

“…Acute cellular rejection occurs frequently during the first few weeks following liver transplantation. During this period, its molecular phenotype is…”
Get full text

Demethylation of the TSDR Is a Marker of Squamous Cell Carcinoma in Transplant Recipients by Sherston, S. N., Vogt, K., Schlickeiser, S., Sawitzki, B., Harden, P. N., Wood, K. J.

“…Malignancy is an important cause of death in transplant recipients. Cutaneous squamous cell carcinoma (cSCC) causes significant morbidity and mortality as 30%…”
Get full text

Identification of Gene Markers for the Prediction of Allograft Rejection or Permanent Acceptance by Sawitzki, B., Bushell, A., Steger, U., Jones, N., Risch, K., Siepert, A., Lehmann, M., Schmitt‐Knosalla, I., Vogt, K., Gebuhr, I., Wood, K., Volk, H.‐D.

“…The clinical success of new treatment strategies aiming on inducing permanent graft acceptance will rely on the ability to determine whether specific…”
Get full text

Molecular Analysis of Renal Allograft Biopsies—More Than a Nice Toy for Researchers? by Volk, H.‐D., Sawitzki, B., Reinke, P.

“…This editorial discuss two papers (see pages 634 and 645) on molecular diagnosis of kidney transplant injury as an alternative to standard histopathological…”
Get full text

The Mitochondrial Protein TCAIM Regulates Activation of T Cells and Thereby Promotes Tolerance Induction of Allogeneic Transplants by Schumann, J., Stanko, K., Woertge, S., Appelt, C., Schumann, M., Kühl, A. A., Panov, I., Schliesser, U., Vogel, S., Ahrlich, S., Vaeth, M., Berberich‐Siebelt, F., Waisman, A., Sawitzki, B.

“…Primary T cell activation and effector cell differentiation is required for rejection of allogeneic grafts in naïve recipients. It has become evident, that…”
Get full text

Permanent CNI Treatment for Prevention of Renal Allograft Rejection in Sensitized Hosts Can Be Replaced by Regulatory T Cells by Siepert, A., Ahrlich, S., Vogt, K., Appelt, C., Stanko, K., Kühl, A., van den Brandt, J., Reichardt, H. M., Nizze, H., Lehmann, M., Tiedge, M., Volk, H.‐D., Sawitzki, B., Reinke, P.

“…Recent data suggest that donor‐specific memory T cells (Tmem) are an independent risk factor for rejection and poor graft function in patients and a major…”
Get full text

Human CD45RA− FoxP3hi Memory‐Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation by Lei, H., Kuchenbecker, L., Streitz, M., Sawitzki, B., Vogt, K., Landwehr‐Kenzel, S., Millward, J., Juelke, K., Babel, N., Neumann, A., Reinke, P., Volk, H.‐D.

“…Adoptive immunotherapy with regulatory T cells (Treg) is a new option to promote immune tolerance following solid organ transplantation (SOT). However, Treg…”
Get full text

Intragraft Mechanisms Associated With the Immunosuppressive Versus the Tolerogenic Effect of CD3 Antibodies in a Mouse Model of Islet Allografts by Baas, M.C, Besançon, A, Sawitzki, B, Mangez, C, Valette, F, Chatenoud, L, You, S

“…Abstract We previously demonstrated the ability of CD3-specific antibodies (Abs) to induce tolerance of fully mismatched pancreatic islets when administered at…”
Get full text

Mechanisms and Rescue Strategies of Calcineurin Inhibitor Mediated Tolerance Abrogation Induced by Anti‐CD4 mAb Treatment by Siepert, A., Brösel, S., Vogt, K., Ahrlich, S., Schmitt‐Knosalla, I., Loddenkemper, C., Kühl, A., Baumgrass, R., Gerstmayer, B., Tomiuk, S., Tiedge, M., Viklický, O., Brabcova, I., Nizze, H., Lehmann, M., Volk, H.‐D., Sawitzki, B.

“…To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs (IS). But IS such as calcineurin inhibitors (CNI), for…”
Get full text

Allogeneic gene-modified tumor cells (RCC-26 IL-7 CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study by Westermann, J, Flörcken, A, Willimsky, G, van Lessen, A, Kopp, J, Takvorian, A, Jöhrens, K, Lukowsky, A, Schönemann, C, Sawitzki, B, Pohla, H, Frank, R, Dörken, B, Schendel, D J, Blankenstein, T, Pezzutto, A

“…Despite novel targeted agents, prognosis of metastatic renal cell cancer (RCC) remains poor, and experimental therapeutic strategies are warranted…”
Get full text

High Weight Differences between Donor and Recipient Affect Early Kidney Graft Function—A Role for Enhanced IL‐6 Signaling by Gong, W., Klöpfel, M., Reutzel‐Selke, A., Jurisch, A., Vogt, K., Haase, S., Höflich, C., Polenz, D., Gerstmayer, B., Tomiuk, S., Volk, H.‐D., Pascher, A., Sawitzki, B.

“…The frequency of delayed function of kidney transplants varies greatly and is associated with quality of graft, donor age and the duration of cold ischemia…”
Get full text

Effects of Remifentanil and Fentanyl on the Cell-Mediated Immune Response in Patients Undergoing Elective Coronary Artery Bypass Graft Surgery by von Dossow, V, Luetz, A, Haas, A, Sawitzki, B, Wernecke, KD, Volk, HD, Spies, CD

“…This prospective randomized pilot study compared the influence of fentanyl-based versus remifentanil-based anaesthesia on cytokine responses and expression of…”
Get full text