Search Results - "Sawicki, Konrad T."

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function by Sato, Tatsuya, Chang, Hsiang-Chun, Bayeva, Marina, Shapiro, Jason S., Ramos-Alonso, Lucia, Kouzu, Hidemichi, Jiang, Xinghang, Liu, Ting, Yar, Sumeyye, Sawicki, Konrad T., Chen, Chunlei, Martínez-Pastor, María Teresa, Stumpo, Deborah J., Schumacker, Paul T., Blackshear, Perry J., Ben-Sahra, Issam, Puig, Sergi, Ardehali, Hossein

“…Cells respond to iron deficiency by activating iron-regulatory proteins to increase cellular iron uptake and availability. However, it is not clear how cells…”
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Circulating Branched Chain Amino Acids and Cardiometabolic Disease by Fine, Keenan S, Wilkins, John T, Sawicki, Konrad T

“…Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as…”
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Reduction in mitochondrial iron alleviates cardiac damage during injury by Chang, Hsiang‐Chun, Wu, Rongxue, Shang, Meng, Sato, Tatsuya, Chen, Chunlei, Shapiro, Jason S, Liu, Ting, Thakur, Anita, Sawicki, Konrad T, Prasad, Sathyamangla VN, Ardehali, Hossein

“…Excess cellular iron increases reactive oxygen species (ROS) production and causes cellular damage. Mitochondria are the major site of iron metabolism and ROS…”
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Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8 by Chang, Hsiang-Chun, Shapiro, Jason Solomon, Jiang, Xinghang, Senyei, Grant, Sato, Teruki, Geier, Justin, Sawicki, Konrad T, Ardehali, Hossein

“…Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts; however, the mechanism for this disorder remains…”
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Optimized protocol for quantification of mitochondrial non-heme and heme iron content in mouse tissues and cultured cells by Sato, Tatsuya, Chang, Hsiang-Chun, Sawicki, Konrad T., Ardehali, Hossein

“…Impaired mitochondrial iron metabolism is associated with aging and a variety of diseases, and there is a growing need to accurately quantify mitochondrial…”
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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life by Sawicki, Konrad T, Ning, Hongyan, Allen, Norrina B, Carnethon, Mercedes R, Wallia, Amisha, Otvos, James D, Ben-Sahra, Issam, McNally, Elizabeth M, Snell-Bergeon, Janet K, Wilkins, John T

“…BACKGROUNDElevated circulating branched chain amino acids (BCAAs), measured at a single time point in middle life, are strongly associated with an increased…”
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Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21 by Sawicki, Konrad T, Chang, Hsiang-Chun, Shapiro, Jason S, Bayeva, Marina, De Jesus, Adam, Finck, Brian N, Wertheim, Jason A, Blackshear, Perry J, Ardehali, Hossein

“…The role of posttranscriptional metabolic gene regulatory programs in diabetes is not well understood. Here, we show that the RNA-binding protein…”
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Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2 by Yang, Xiaoyan, Park, Seong-Hoon, Chang, Hsiang-Chun, Shapiro, Jason S, Vassilopoulos, Athanassios, Sawicki, Konrad T, Chen, Chunlei, Shang, Meng, Burridge, Paul W, Epting, Conrad L, Wilsbacher, Lisa D, Jenkitkasemwong, Supak, Knutson, Mitchell, Gius, David, Ardehali, Hossein

“…SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including tumorigenesis, metabolism, and inflammation. Since these processes…”
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Opposing effects of genetic variation in MTCH2 for obesity versus heart failure by Fischer, Julie A, Monroe, Tanner O, Pesce, Lorenzo L, Sawicki, Konrad T, Quattrocelli, Mattia, Bauer, Rosemary, Kearns, Samuel D, Wolf, Matthew J, Puckelwartz, Megan J, McNally, Elizabeth M

“…Genetic variation in genes regulating metabolism may be advantageous in some settings but not others. The non-failing adult heart relies heavily on fatty acids…”
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Role of Interferon α (IFNα)-inducible Schlafen-5 in Regulation of Anchorage-independent Growth and Invasion of Malignant Melanoma Cells by Katsoulidis, Efstratios, Mavrommatis, Evangelos, Woodard, Jennifer, Shields, Mario A., Sassano, Antonella, Carayol, Nathalie, Sawicki, Konrad T., Munshi, Hidayatullah G., Platanias, Leonidas C.

“…IFNα exerts potent inhibitory activities against malignant melanoma cells in vitro and in vivo, but the mechanisms by which it generates its antitumor effects…”
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Longitudinal trajectories of branched chain amino acids through young adulthood and diabetes in later life by Sawicki, Konrad T, Ning, Hongyan, Allen, Norrina B, Carnethon, Mercedes R, Wallia, Amisha, Otvos, James D, Ben-Sahra, Issam, McNally, Elizabeth M, Snell-Bergeon, Janet K, Wilkins, John T

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Metabolic liability for weight gain in early adulthood by Murthy, Venkatesh L., Mosley, Jonathan D., Perry, Andrew S., Jacobs, David R., Tanriverdi, Kahraman, Zhao, Shilin, Sawicki, Konrad T., Carnethon, Mercedes, Wilkins, John T., Nayor, Matthew, Das, Saumya, Abel, E. Dale, Freedman, Jane E., Clish, Clary B., Shah, Ravi V.

“…While weight gain is associated with a host of chronic illnesses, efforts in obesity have relied on single “snapshots” of body mass index (BMI) to guide…”
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Outcomes After Esophagectomy in Patients With Prior Antireflux or Hiatal Hernia Surgery by Chang, Andrew C., MD, Lee, Julia S., MS, Sawicki, Konrad T, Pickens, Allan, MD, Orringer, Mark B., MD

“…Background Esophagectomy is indicated occasionally for the treatment of patients with refractory gastroesophageal reflux disease (GERD) or recurrent hiatus…”
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Abstract P200: Cumulative Circulating Branched Chain Amino Acid Exposure in Young Adulthood and Incident Atherosclerotic Cardiovascular Disease (ASCVD) in Later Life: The CARDIA Study by Sawicki, Konrad T, Ning, Hongyan, Fine, Keenan, Otvos, James D, Carnethon, Mercedes R, Shah, Ravi V, Murthy, Venkatesh L, Wilkins, John T

“…IntroductionCirculating branched chain amino acid (BCAA) levels are associated with the development of diabetes mellitus (DM) and downstream ASCVD in…”
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Abstract 13588: Association of Longitudinal Trajectories of Branched Chain Amino Acids Through Young Adulthood With Diabetes in Later Life: The CARDIA Study by Sawicki, Konrad T, Ning, Hongyan, Allen, Norrina B, Carnethon, Mercedes R, Wallia, Amisha, Otvos, James D, Ben Sahra, Issam, McNally, Elizabeth M, Snell-Bergeon, Janet, Wilkins, John T

“…IntroductionBranched chain amino acids (BCAA), measured at a single timepoint in midlife, are directly associated with risk for incident type 2 diabetes…”
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Abstract 13600: Performance of a Multi-Metabolite Score Added to a Risk Prediction Model for Incident Diabetes in Young Adults: The CARDIA Study by Sawicki, Konrad T, Ning, Hongyan, Fine, Keenan, Allen, Norrina B, Carnethon, Mercedes R, Otvos, James D, Shah, Ravi V, Murthy, Venkatesh L, Wilkins, John T

“…IntroductionThe Finnish Diabetes Risk Score (FINDRISC) is a risk prediction tool used to estimate absolute risk for type 2 diabetes mellitus (DM), a critical…”
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Abstract P453: Apolipoprotein B, Low-Density Lipoprotein Particle Number, Non-High-Denisity Lipoprotein Cholesterol, Low-Density Lipoprotein Cholesterol, and Total Cholesterol for Atherosclerotic Cardiovascular Disease Risk Prediction in Young Adults by Wilkins, John T, Ning, Hongyan, Sawicki, Konrad, Sawicki, Konrad T, Sniderman, Allan D, Otvos, James D, Rana, Jamal S, Murthy, Venkatesh, Murthy, Venkatesh L, Shah, Ravi V, Allen, Norrina B, Lloyd-Jones, Donald

“…IntroductionMeasures of atherogenic particle number (apoB and LDL particle number [LDL-P]) are stronger predictors of atherosclerotic cardiovascular disease…”
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Abstract P594: High-Density Lipoprotein Particle Concentrations and Long-Term Atherosclerotic Disease Risk in Young Adults by Wilkins, John T, Alruwaili, Waleed, Ning, Hongyan, Sawicki, Konrad T, Sniderman, Allan D, Otvos, James D, Jacobs, David R, Murthy, Venkatesh L, Shah, Ravi V, Rohatgi, Anand, Allen, Norrina B

“…IntroductionHDL particles vary in size and concentration. Indices of overall HDL particle concentration (HDL-P) and the concentrations of different HDL size…”
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Abstract 14252: Cumulative Apolipoprotein B Blood Concentrations During Early Adulthood and Incident Atherosclerotic Cardiovascular Disease Risk After Age 40 Years: The Coronary Artery Risk Development in Young Adults Study by Wilkins, John T, Ning, Hongyan, Sniderman, Allan D, Stone, Neil J, Otvos, James D, Jacobs, David R, Sawicki, Konrad, Sawicki, Konrad T, Murthy, Venkatesh L, Shah, Ravi V, Allen, Norrina B, Lloyd-Jones, Donald

“…IntroductionThe associations between cumulative exposure to apolipoprotein B (apoB) containing lipoproteins across early adult life and incident ASCVD in later…”
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Abstract 12528: ALR Protein, a Critical Protein in Cardiac Development, Regulates Cellular Iron Homeostasis by Modulating Mitochondrial Transport of ATP-Binding Cassette (ABC)-B8 by Chang, Hsiang-Chun, Jiang, Xinghang, Senyei, Grant, Shapiro, Jason S, Sawicki, Konrad T, Ardehali, Hossein

“…IntroductionIron is an essential molecule for normal cellular physiology, and altered cellular iron homeostasis is commonly observed in diseases with…”
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