Search Results - "Sawicki, Diane R"

Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications by Van Zandt, Michael C, Jones, Michael L, Gunn, David E, Geraci, Leo S, Jones, J. Howard, Sawicki, Diane R, Sredy, Janet, Jacot, Jorge L, DiCioccio, A. Thomas, Petrova, Tatiana, Mitschler, Andre, Podjarny, Alberto D

“…Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective…”
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Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b] pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications by VAN ZANDT, Michael C, DOAN, Brian, SAWICKI, Diane R, SREDY, Janet, PODJARNY, Alberto D

“…Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective…”
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PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[b]naphtho[2,3-d]furans and 11-Arylbenzo[b]naphtho[2,3-d]thiophenes by Wrobel, Jay, Sredy, Janet, Moxham, Christopher, Dietrich, Arlene, Li, Zenan, Sawicki, Diane R, Seestaller, Laura, Wu, Li, Katz, Alan, Sullivan, Donald, Tio, Cesario, Zhang, Zhong-Yin

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Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications by Van Zandt, Michael C., Sibley, Evelyn O., McCann, Erin E., Combs, Kerry J., Flam, Brenda, Sawicki, Diane R., Sabetta, Al, Carrington, Anne, Sredy, Janet, Howard, Eduardo, Mitschler, Andre, Podjarny, Alberto D.

“…[Display omitted] Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent…”
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Novel Benzofuran and Benzothiophene Biphenyls as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties by Malamas, Michael S, Sredy, Janet, Moxham, Christopher, Katz, Alan, Xu, Weixin, McDevitt, Robert, Adebayo, Folake O, Sawicki, Diane R, Seestaller, Laura, Sullivan, Donald, Taylor, Joseph R

“…Insulin resistance in the liver and peripheral tissues, together with a pancreatic cell defect, are the common causes of Type 2 diabetes. It is now appreciated…”
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New Azolidinediones as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties by Malamas, Michael S, Sredy, Janet, Gunawan, Iwan, Mihan, Brenda, Sawicki, Diane R, Seestaller, Laura, Sullivan, Donald, Flam, Brenda R

“…Insulin resistance in the liver and peripheral tissues together with a pancreatic cell defect are the common causes of type 2 diabetes. It is now appreciated…”
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Synthesis and PTP1B Inhibition of Novel 4-Aryl-1-Oxa-9-Thiacyclopenta[ b]fluorenes by Wrobel, Jay, Li, Zenan, Sredy, Janet, Sawicki, Diane R, Seestaller, Laura, Sullivan, Donald

“…Novel 4-aryl-1-oxa-9-thiacyclopenta[ b]fluorenes were designed, synthesized, and evaluated as inhibitors of the protein tyrosine phosphatase, PTP1B. Compounds…”
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Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin -1-yl]ace tic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications by Van Zandt, Michael C, Doan, Brian, Sawicki, Diane R, Sredy, Janet, Podjarny, Alberto D

“…Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective…”
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Insulin resistance is associated with abnormal dephosphorylation of a synthetic phosphopeptide corresponding to the major autophosphorylation sites of the insulin receptor by Sredy, Janet, Sawicki, Diane R., Flam, Brenda R., Sullivan, Donald

“…Insulin resistance in the ob/ob mouse model is associated with a reduction in insulin-induced protein-tyrosine phosphorylation in tissues such as liver. To…”
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Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors by Sredy, J, Flam, B R, Sawicki, D R

“…The ability of aldose reductase inhibitors to prevent the decline in neural Na+,K(+)-ATPase activity in diabetic rats has not been confirmed by all…”
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Polyol pathway activity in nervous tissues of diabetic and galactose-fed rats: effect of dietary galactose withdrawal or tolrestat intervention therapy by Sredy, J, Sawicki, D R, Notvest, R R

“…Enhanced polyol pathway activity resulting in an accumulation of sorbitol and a depletion of myoinositol in nervous tissues has been proposed to be important…”
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