Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women

Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women

Increased plasma trimethylamine N-oxide (TMAO) levels have been associated with cardiovascular diseases (CVD). L-carnitine induces TMAO elevation in human blood, and thus, it has been suggested as developing atherosclerosis. The aim of this study was to determine the relation between selected marker...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity Vol. 2019; no. 2019; pp. 1 - 6
Main Authors: Lysiak-Szydlowska, Wieslawa, Grinberga, Solveiga, Hartmane, Dace, Sawicka, Angelika Katarzyna, Samulak, Joanna Jolanta, Olek, Robert Antoni, Pugovics, Osvalds
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Aged
Atherosclerosis
Biomarkers
Biomarkers - metabolism
Blood
Blood cell count
Cardiovascular disease
Cardiovascular diseases
Coronary vessels
Cytokines
Development and progression
Diabetes
Female
Health aspects
Healthy Volunteers
Homocysteine
Humans
Levocarnitine
Low density lipoproteins
Lymphocytes
Medical research
Medicine, Experimental
Metabolism
Metabolites
Methylamines - metabolism
Microbiota
Neutrophils
Nutrition
Oxidation
Oxidative Stress
Proteins
Studies
Thrombosis
Uric acid
Variance analysis
Women
Womens health
United States > US
Germany
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Summary:Increased plasma trimethylamine N-oxide (TMAO) levels have been associated with cardiovascular diseases (CVD). L-carnitine induces TMAO elevation in human blood, and thus, it has been suggested as developing atherosclerosis. The aim of this study was to determine the relation between selected markers of oxidative stress and plasma TMAO concentration induced by L-carnitine supplementation for 24 weeks in healthy aged women. Twenty aged women were supplemented during 24 weeks with either 1500 mg L-carnitine-L-tartrate (n=11) or isonitrogenous placebo (n=9) per day. Fasting blood samples were taken from antecubital vein. L-carnitine supplementation induced an increase in TMAO, but not in γ-butyrobetaine (GBB). Moreover, there were no significant changes in serum ox-LDL, myeloperoxidase, protein carbonyls, homocysteine, and uric acid concentrations due to supplementation. Significant reduction in white blood cell counts has been observed following 24-week supplementation, but not attributable to L-carnitine. Our results in healthy aged women indicated no relation between TMAO and any determined marker of oxidative stress over the period of 24 weeks. At the same time, plasma GBB levels were not affected by L-carnitine supplementation. Further clinical studies of plasma GBB level as a prognostic marker are needed.
Bibliography:ObjectType-Article-1
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Guest Editor: Sergio Di Meo
ISSN:1942-0900
1942-0994
DOI:10.1155/2019/6247169