Ultrasonographic comparison of gastric motility between diabetic gastroparesis patients with and without metabolic syndrome

Background and Aims: Diabetic patients with poor glycemic control or long standing disease often have impaired gastric motility. Recently, metabolic factors such as blood glucose have been reported as influencing gastric motility independently of autonomic neuropathy. Many diabetic patients have me...

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Published in:	Journal of gastroenterology and hepatology Vol. 23; no. 7pt2; pp. e17 - e22
Main Authors:	Sogabe, Masahiro, Kimura, Yoshitaka, Iwaki, Hiroshi, Okita, Yoshio, Hibino, Shingo, Sawda, Seizo, Okahisa, Toshiya, Okamoto, Koichi, Tsujigami, Koji, Hayashi, Hiroshige, Hukui, Yasuo, Nakamura, Toshio, Taniki, Toshikatsu, Nakasono, Masahiko, Muguruma, Naoki, Okamura, Seisuke, Ito, Susumu
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Publishing Asia 01-07-2008
Subjects:	Adult Aged autonomic neuropathy Diabetes Complications - complications Diabetes Complications - diagnostic imaging Diabetes Complications - physiopathology diabetic gastroparesis Female Gastric Emptying Gastroparesis - complications Gastroparesis - diagnostic imaging Gastroparesis - physiopathology Humans Male metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - diagnostic imaging Metabolic Syndrome - physiopathology Middle Aged motility index Ultrasonography
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Summary:	Background and Aims: Diabetic patients with poor glycemic control or long standing disease often have impaired gastric motility. Recently, metabolic factors such as blood glucose have been reported as influencing gastric motility independently of autonomic neuropathy. Many diabetic patients have metabolic syndrome, which is strongly associated with coronary and other diseases. We investigated whether metabolic syndrome influences diabetic gastroparesis patients. Methods: We observed gastric motility ultrasonographically in diabetic gastroparesis patients including nine with and nine without metabolic syndrome. Both groups complained of upper abdominal symptoms when hospitalized to improve blood sugar control. All patients underwent upper gastrointestinal endoscopy to rule out gastric and duodenal lesions. All had autonomic neuropathy. Gastric motility was evaluated within 3 days after admission by transabdominal ultrasonography after a test meal. Results: Gastric emptying was 45.0 ± 13.7% in patients with and 39.1 ± 11.9% in patients without metabolic syndrome, which was not statistically significant. Frequency of gastric contractions was 8.33 ± 2.78 per 3 min in patients with metabolic syndrome and 7.44 ± 2.13 per 3 min in the others, which was not statistically significant. The motility index, which involves antral contractility, was 3.21 ± 2.18 in patients with metabolic syndrome and 2.80 ± 1.87 in the others, which was not statistically significant. Conclusions: Metabolic syndrome did not appear to contribute to delayed gastric motility in diabetic gastroparesis.
Bibliography:	ArticleID:JGH5055 ark:/67375/WNG-73G7ZCZV-M istex:876847CB8C5C228111B85998C341ACC38D078B02 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0815-9319 1440-1746
DOI:	10.1111/j.1440-1746.2007.05055.x