Search Results - "Sawchuk, Tracy"

Granzyme B-Induced Apoptosis Requires Both Direct Caspase Activation and Relief of Caspase Inhibition by Goping, Ing Swie, Barry, Michele, Liston, Peter, Sawchuk, Tracy, Constantinescu, Gabriela, Michalak, Karolina M., Shostak, Irene, Roberts, Darren L., Hunter, Allison M., Korneluk, Robert, Bleackley, R. Chris

“…Cytotoxic lymphocytes employ Granzyme B as a potent initiator of apoptosis to cleave and activate effector caspases. Unexpectedly, cells transfected with Bcl-2…”
Get full text

Granzyme B Induces Endothelial Cell Apoptosis and Contributes to the Development of Transplant Vascular Disease by Choy, Jonathan C., Cruz, Rani P., Kerjner, Alexandra, Geisbrecht, Jennette, Sawchuk, Tracy, Fraser, Stephanie A., Hudig, Dorothy, Bleackley, R. Chris, Jirik, Frank R., McManus, Bruce M., Granville, David J.

“…Endothelial cell death induced by cytotoxic T cells is a key initiating event in the development of transplant vascular disease (TVD), the leading cause of…”
Get full text

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis by Motyka, Bruce, Korbutt, Gregory, Pinkoski, Michael J, Heibein, Jeffrey A, Caputo, Antonio, Hobman, Marita, Barry, Michele, Shostak, Irene, Sawchuk, Tracy, Holmes, Charles F.B, Gauldie, Jack, Bleackley, R.Chris

“…The serine proteinase granzyme B is crucial for the rapid induction of target cell apoptosis by cytotoxic T cells. Granzyme B was recently demonstrated to…”
Get full text

Cytotoxic T lymphocytes overcome Bcl-2 inhibition: target cells contribute to their own demise by Goping, Ing Swie, Sawchuk, Tracy, Rieger, Aja, Shostak, Irene, Bleackley, R. Chris

“…Cytotoxic T lymphocytes (CTLs) eliminate pathogenic cells in large part through the activity of the serine protease granzyme B (grB). However, while the…”
Get full text

Identification of α-tubulin as a granzyme B substrate during CTL-mediated apoptosis by Goping, Ing Swie, Sawchuk, Tracy, Underhill, D. Alan, Bleackley, R. Chris

“…Cytotoxic lymphocytes induce target cell apoptosis via two major pathways: Fas/FasL and granule exocytosis. The latter pathway has largely been defined by the…”
Get full text

Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate by Veugelers, Kirstin, Motyka, Bruce, Goping, Ing Swie, Shostak, Irene, Sawchuk, Tracy, Bleackley, R Chris

“…During granule-mediated killing by cytotoxic T lymphocytes or natural killer cells, the serine protease granzyme B enters the target cell by endocytosis and…”
Get full text

Granzyme B Induces Smooth Muscle Cell Apoptosis in the Absence of Perforin: Involvement of Extracellular Matrix Degradation by Choy, Jonathan C, Hung, Vivian H.Y, Hunter, Arwen L, Cheung, Paul K, Motyka, Bruce, Goping, Ing Swie, Sawchuk, Tracy, Bleackley, R Chris, Podor, Thomas J, McManus, Bruce M, Granville, David J

“…OBJECTIVE—T cell-induced cytotoxicity, of which granzyme B is a key mediator, is believed to contribute to the pathogenesis of inflammatory vascular diseases…”
Get full text

The granzyme B–serglycin complex from cytotoxic granules requires dynamin for endocytosis by Veugelers, Kirstin, Motyka, Bruce, Frantz, Christine, Shostak, Irene, Sawchuk, Tracy, Bleackley, R. Chris

“…Cytotoxic T lymphocytes and natural killer cells destroy target cells via the directed exocytosis of lytic effector molecules such as perforin and granzymes…”
Get full text

Identification of [alpha]-tubulin as a granzyme B substrate during CTL-mediated apoptosis by Goping, Ing Swie, Sawchuk, Tracy, Underhill, D. Alan, Bleackley, R. Chris

“…Cytotoxic lymphocytes induce target cell apoptosis via two major pathways: Fas/FasL and granule exocytosis. The latter pathway has largely been defined by the…”
Get full text

Granzyme b induces smooth muscle cell apoptosis in the absence of perforin: Involvement of extracellular matrix degradation. Editorial by CHOY, Jonathan C, HUNG, Vivian H. Y, GRANVILLE, David J, LINDSTEDT, Ken A, KOVANEN, Petri T, HUNTER, Arwen L, CHEUNG, Paul K, MOTYKA, Bruce, ING SWIE GOPING, SAWCHUK, Tracy, BLEACKLEY, R. Chris, PODOR, Thomas J, MCMANUS, Bruce M

Get full text