Search Results - "Sawaya, R."

Structural Studies of Amyloid Proteins at the Molecular Level by Eisenberg, David S, Sawaya, Michael R

“…Dozens of proteins are known to convert to the aggregated amyloid state. These include fibrils associated with systemic and neurodegenerative diseases and…”
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The expanding amyloid family: Structure, stability, function, and pathogenesis by Sawaya, Michael R., Hughes, Michael P., Rodriguez, Jose A., Riek, Roland, Eisenberg, David S.

“…The hidden world of amyloid biology has suddenly snapped into atomic-level focus, revealing over 80 amyloid protein fibrils, both pathogenic and functional…”
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Cryo-EM structures of four polymorphic TDP-43 amyloid cores by Cao, Qin, Boyer, David R., Sawaya, Michael R., Ge, Peng, Eisenberg, David S.

“…The DNA and RNA processing protein TDP-43 undergoes both functional and pathogenic aggregation. Functional TDP-43 aggregates form reversible, transient species…”
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Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels by Kato, Masato, Han, Tina W., Xie, Shanhai, Shi, Kevin, Du, Xinlin, Wu, Leeju C., Mirzaei, Hamid, Goldsmith, Elizabeth J., Longgood, Jamie, Pei, Jimin, Grishin, Nick V., Frantz, Douglas E., Schneider, Jay W., Chen, She, Li, Lin, Sawaya, Michael R., Eisenberg, David, Tycko, Robert, McKnight, Steven L.

“…Eukaryotic cells contain assemblies of RNAs and proteins termed RNA granules. Many proteins within these bodies contain KH or RRM RNA-binding domains as well…”
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Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel by Li, Binsen, Ge, Peng, Murray, Kevin A., Sheth, Phorum, Zhang, Meng, Nair, Gayatri, Sawaya, Michael R., Shin, Woo Shik, Boyer, David R., Ye, Shulin, Eisenberg, David S., Zhou, Z. Hong, Jiang, Lin

“…α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding activities, contributing differently to synucleinopathies. Despite numerous…”
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Structure-based inhibitors of tau aggregation by Seidler, P. M., Boyer, D. R., Rodriguez, J. A., Sawaya, M. R., Cascio, D., Murray, K., Gonen, T., Eisenberg, D. S.

“…Aggregated tau protein is associated with over 20 neurological disorders, which include Alzheimer's disease. Previous work has shown that tau's sequence…”
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Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography by Zhang, Haitao, Unal, Hamiyet, Gati, Cornelius, Han, Gye Won, Liu, Wei, Zatsepin, Nadia A., James, Daniel, Wang, Dingjie, Nelson, Garrett, Weierstall, Uwe, Sawaya, Michael R., Xu, Qingping, Messerschmidt, Marc, Williams, Garth J., Boutet, Sébastien, Yefanov, Oleksandr M., White, Thomas A., Wang, Chong, Ishchenko, Andrii, Tirupula, Kalyan C., Desnoyer, Russell, Coe, Jesse, Conrad, Chelsie E., Fromme, Petra, Stevens, Raymond C., Katritch, Vsevolod, Karnik, Sadashiva S., Cherezov, Vadim

“…Angiotensin II type 1 receptor (AT1R) is a G protein-coupled receptor that serves as a primary regulator for blood pressure maintenance. Although several…”
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CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid by Lu, Jiahui, Cao, Qin, Hughes, Michael P., Sawaya, Michael R., Boyer, David R., Cascio, Duilio, Eisenberg, David S.

“…hnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It forms fibrils both under cellular stress and in mutated form in neurodegenerative…”
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Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro by Seidler, Paul M., Murray, Kevin A., Boyer, David R., Ge, Peng, Sawaya, Michael R., Hu, Carolyn J., Cheng, Xinyi, Abskharon, Romany, Pan, Hope, DeTure, Michael A., Williams, Christopher K., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.

“…Alzheimer’s disease (AD) is the consequence of neuronal death and brain atrophy associated with the aggregation of protein tau into fibrils. Thus…”
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Three-dimensional coordinates of individual atoms in materials revealed by electron tomography by Xu, Rui, Chen, Chien-Chun, Wu, Li, Scott, M. C., Theis, W., Ophus, Colin, Bartels, Matthias, Yang, Yongsoo, Ramezani-Dakhel, Hadi, Sawaya, Michael R., Heinz, Hendrik, Marks, Laurence D., Ercius, Peter, Miao, Jianwei

“…Electron tomography is used to create a 3D reconstruction of a tungsten needle that allows the positions of individual atoms to be localized with a precision…”
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Atomic View of a Toxic Amyloid Small Oligomer by Laganowsky, Arthur, Liu, Cong, Sawaya, Michael R., Whitelegge, Julian P., Park, Jiyong, Zhao, Minglei, Pensalfini, Anna, Soriaga, Angela B., Landau, Meytal, Teng, Poh K., Cascio, Duilio, Glabe, Charles, Eisenberg, David

“…Amyloid diseases, including Alzheimer's, Parkinson's, and the priori conditions, are each associated with a particular protein in fibrillar form. These amyloid…”
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Molecular basis for amyloid-β polymorphism by Colletier, Jacques-Philippe, Laganowsky, Arthur, Landau, Meytal, Zhao, Minglei, Soriaga, Angela B, Goldschmidt, Lukasz, Flot, David, Cascio, Duilio, Sawaya, Michael R, Eisenberg, David

“…Amyloid-beta (Aβ) aggregates are the main constituent of senile plaques, the histological hallmark of Alzheimer’s disease. Aβ molecules form β-sheet containing…”
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Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2 by Guenther, Elizabeth L., Ge, Peng, Trinh, Hamilton, Sawaya, Michael R., Cascio, Duilio, Boyer, David R., Gonen, Tamir, Zhou, Z. Hong, Eisenberg, David S.

“…Proteins in the fibrous amyloid state are a major hallmark of neurodegenerative disease. Understanding the multiple conformations, or polymorphs, of amyloid…”
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Review article: the biology, diagnosis and management of gastrointestinal stromal tumours by Iorio, N., Sawaya, R. A., Friedenberg, F. K.

“…Summary Background Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumours of the gastrointestinal tract with an increasing incidence…”
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Expanding metabolism for biosynthesis of nonnatural alcohols by Zhang, Kechun, Sawaya, Michael R, Eisenberg, David S, Liao, James C

“…Nature uses a limited set of metabolites to perform all of the biochemical reactions. To increase the metabolic capabilities of biological systems, we have…”
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Uncovering the Mechanism of Aggregation of Human Transthyretin by Saelices, Lorena, Johnson, Lisa M., Liang, Wilson Y., Sawaya, Michael R., Cascio, Duilio, Ruchala, Piotr, Whitelegge, Julian, Jiang, Lin, Riek, Roland, Eisenberg, David S.

“…The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin…”
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Isobutanol production freed from biological limits using synthetic biochemistry by Sherkhanov, Saken, Korman, Tyler P., Chan, Sum, Faham, Salem, Liu, Hongjiang, Sawaya, Michael R., Hsu, Wan-Ting, Vikram, Ellee, Cheng, Tiffany, Bowie, James U.

“…Cost competitive conversion of biomass-derived sugars into biofuel will require high yields, high volumetric productivities and high titers. Suitable…”
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Catastrophic disassembly of actin filaments via Mical-mediated oxidation by Grintsevich, Elena E., Ge, Peng, Sawaya, Michael R., Yesilyurt, Hunkar Gizem, Terman, Jonathan R., Zhou, Z. Hong, Reisler, Emil

“…Actin filament assembly and disassembly are vital for cell functions. MICAL Redox enzymes are important post-translational effectors of actin that…”
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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules by Maji, Samir K, Perrin, Marilyn H, Sawaya, Michael R, Jessberger, Sebastian, Vadodaria, Krishna, Rissman, Robert A, Singru, Praful S, Nilsson, K. Peter R, Simon, Rozalyn, Schubert, David, Eisenberg, David, Rivier, Jean, Sawchenko, Paul, Vale, Wylie, Riek, Roland

“…Amyloids are highly organized cross-β-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease…”
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Toward the Structural Genomics of Complexes: Crystal Structure of a PE/PPE Protein Complex from Mycobacterium tuberculosis by Strong, Michael, Sawaya, Michael R., Wang, Shuishu, Phillips, Martin, Cascio, Duilio, Eisenberg, David

“…The developing science called structural genomics has focused to date mainly on high-throughput expression of individual proteins, followed by their…”
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