Search Results - "Sawalha, A H"

Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress by Tran, L, Chaloner, A, Sawalha, A.H, Greenwood Van-Meerveld, B

“…Summary Epigenetic molecular mechanisms, which include DNA methylation and histone deacetylation, are implicated in the dysregulation of the…”
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Activation of the JAK/STAT pathway in Behcet’s disease by Tulunay, A, Dozmorov, M G, Ture-Ozdemir, F, Yilmaz, V, Eksioglu-Demiralp, E, Alibaz-Oner, F, Ozen, G, Wren, J D, Saruhan-Direskeneli, G, Sawalha, A H, Direskeneli, H

“…Th1/Th17-type T-cell responses are upregulated in Behcet’s disease (BD). However, signaling pathways associated with this aberrant immune response are not…”
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Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus by Sawalha, A H, Kaufman, K M, Kelly, J A, Adler, A J, Aberle, T, Kilpatrick, J, Wakeland, E K, Li, Q-Z, Wandstrat, A E, Karp, D R, James, J A, Merrill, J T, Lipsky, P, Harley, J B

“…The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of…”
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Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients by Sawalha, A H, Jeffries, M, Webb, R, Lu, Q, Gorelik, G, Ray, D, Osban, J, Knowlton, N, Johnson, K, Richardson, B

“…Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against a host of nuclear antigens. The…”
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Overexpression of methyl-CpG-binding protein 2 and autoimmunity: evidence from MECP2 duplication syndrome, lupus, MECP2 transgenic and Mecp2 deficient mice by Sawalha, AH

“…Methyl-CpG-binding protein 2 (MeCP2) is a key transcriptional regulator that can induce either silencing or activation of target genes. Genetic polymorphisms…”
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DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks by Hughes, T, Webb, R, Fei, Y, Wren, J D, Sawalha, A H

“…DNA methylation is an epigenetic mark that is critical in determining chromatin accessibility and regulating gene expression. This epigenetic mechanism has an…”
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Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective by Jeffries, M, Hamadeh, F, Aberle, T, Glenn, S, Kamen, DL, Kelly, JA, Reichlin, M, Harley, JB, Sawalha, AH

“…Systemic lupus erythematosus is a chronic autoimmune disease that can be associated with a variety of haematological manifestations. We identified 76 patients…”
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A disease-associated gene desert directs macrophage inflammation through ETS2 by Stankey, C. T., Bourges, C., Haag, L. M., Turner-Stokes, T., Piedade, A. P., Palmer-Jones, C., Papa, I., Silva dos Santos, M., Zhang, Q., Cameron, A. J., Legrini, A., Zhang, T., Wood, C. S., New, F. N., Randzavola, L. O., Speidel, L., Brown, A. C., Hall, A., Saffioti, F., Parkes, E. C., Edwards, W., Direskeneli, H., Grayson, P. C., Jiang, L., Merkel, P. A., Saruhan-Direskeneli, G., Sawalha, A. H., Tombetti, E., Quaglia, A., Thorburn, D., Knight, J. C., Rochford, A. P., Murray, C. D., Divakar, P., Green, M., Nye, E., MacRae, J. I., Jamieson, N. B., Skoglund, P., Cader, M. Z., Wallace, C., Thomas, D. C., Lee, J. C.

“…Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to human health 1 . This is compounded by the limited efficacy of available…”
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Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients by Malik, S., Bruner, G.R., Williams-Weese, C., Feo, L., Hal Scofield, R., Reichlin, M., Harley, J.B., Sawalha, A.H.

“…Previous reports suggest a protective role for anti-La autoantibody against the development of lupus nephritis. We studied the effect of anti-La on the…”
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Sulpha allergy in lupus patients: a clinical perspective by Jeffries, M, Bruner, G, Glenn, S, Sadanandan, P, Carson, CW, Harley, JB, Sawalha, AH

“…Abstract Systemic lupus erythematosus is a chronic, relapsing autoimmune disease that can affect multiple organ systems. An increased prevalence of drug…”
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Genetic linkage of systemic lupus erythematosus with chromosome 11q14 (SLEH1) in African-American families stratified by a nucleolar antinuclear antibody pattern by Sawalha, A H, Namjou, B, Nath, S K, Kilpatrick, J, Germundson, A, Kelly, J A, Hutchings, D, James, J, Harley, J

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with complex genetics. We evaluated pedigrees multiplex for SLE that had an affected with…”
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Activation of the JAK/STAT pathway in Behcet's disease by Tulunay, A, Dozmorov, M G, Ture-Ozdemir, F, Yilmaz, V, Eksioglu-Demiralp, E, Alibaz-Oner, F, Ozen, G, Wren, J D, Saruhan-Direskeneli, G, Sawalha, A H, Direskeneli, H

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Erratum: Activation of the JAK/STAT pathway in Behcet’s disease by Tulunay, A, Dozmorov, M G, Ture-Ozdemir, F, Yilmaz, V, Eksioglu-Demiralp, E, Alibaz-Oner, F, Ozen, G, Wren, J D, Saruhan-Direskeneli, G, Sawalha, A H, Direskeneli, H

“…Correction to: Genes and Immunity (2014) 0, 000–000; doi:10.1038/gene.2014.64; published online 20 November 2014 Since the online publication of this paper,…”
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Ankylosing spondylitis in north Jordan: descriptive and analytical study by Askari, Ayman, Al-Bdour, Muawyah D, Saadeh, Abdalla, Sawalha, Amr H

“…OBJECTIVE A study of ankylosing spondylitis in Jordan, which has been underinvestigated in this region. METHODS Twenty two patients were studied according to…”
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54 A LOWERED FREQUENCY OF HELICOBACTER PYLORI SEROPOSITIVITY IN AFRICAN-AMERICAN WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS by Sawalha, A. H., Schmid, W. R., Binder, S. R., Bacino, D. K., Harley, J. B.

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Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients by Webb, Ryan, Kelly, Jennifer A, Somers, Emily C, Hughes, Travis, Kaufman, Kenneth M, Sanchez, Elena, Nath, Swapan K, Bruner, Gail, Alarcón-Riquelme, Marta E, Gilkeson, Gary S, Kamen, Diane L, Richardson, Bruce C, Harley, John B, Sawalha, Amr H

“…Systemic lupus erythematosus (SLE) is a chronic, multiorgan, autoimmune disease that affects people of all ages and ethnicities. To explore the relationship…”
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Genetic-epigenetic interaction in lupus by Sawalha, AH

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Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behçet's disease by Coit, Patrick, Mumcu, Gonca, Ture-Ozdemir, Filiz, Unal, Ali Ugur, Alpar, Ugur, Bostanci, Nagihan, Ergun, Tulin, Direskeneli, Haner, Sawalha, Amr H

“…Abstract Behçet's disease (BD) is characterized by recurrent oro-genital ulcers, mucocutaneous lesions, and serious organ involvement. We investigated the…”
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Genetic association between methyl-CpG binding protein 2 (MECP2) and primary Sjogren's syndrome by Cobb, Beth L, Fei, Yiping, Jonsson, Roland, Bolstad, Anne Isine, Brun, Johan G, Rischmueller, Maureen, Lester, Susan E, Witte, Torsten, Illei, Gabor, Brennan, Michael, Bowman, Simon, Moser, Kathy L, Harley, John B, Sawalha, Amr H

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TIR-domain-containing adaptor protein gene TIRAP S180L polymorphism is not increased in Behçet's disease patients in two ethnic cohorts by Turunc, Gorkem, Coskun, Doga, Alibaz-Oner, Fatma, Coit, Patrick, Duzgun, Nursen, Alpsoy, Erkan, Yentur, Sibel P, Salvarani, Carlo, Casali, Bruno, Kötter, Ina, Ergun, Tulin, Direskeneli, Haner, Sawalha, Amr H, Saruhan-Direskeneli, Guher

“…The single nucleotide polymorphism (SNP) of TIRAP (Serine 180 leucine, S180L) that is shown to be associated with Behçet's disease (BD) in a European-derived…”
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