Search Results - "Sawai, Catherine M"

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals by Sawai, Catherine M., Babovic, Sonja, Upadhaya, Samik, Knapp, David J.H.F., Lavin, Yonit, Lau, Colleen M., Goloborodko, Anton, Feng, Jue, Fujisaki, Joji, Ding, Lei, Mirny, Leonid A., Merad, Miriam, Eaves, Connie J., Reizis, Boris

“…Hematopoietic stem cells (HSCs) sustain long-term reconstitution of hematopoiesis in transplantation recipients, yet their role in the endogenous steady-state…”
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Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche by Upadhaya, Samik, Krichevsky, Oleg, Akhmetzyanova, Ilseyar, Sawai, Catherine M., Fooksman, David R., Reizis, Boris

“…Adult mammalian hematopoietic stem cells (HSCs) reside in the bone marrow (BM) but can be mobilized into blood for use in transplantation. HSCs interact with…”
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Counting blood precursors by Duchamp de Chastaigne, Sarah, Sawai, Catherine M

“…A new mathematical model can estimate the number of precursor cells that contribute to regenerating blood cells in mice…”
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Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells by Sawai, Catherine M, Sisirak, Vanja, Ghosh, Hiyaa S, Hou, Esther Z, Ceribelli, Michele, Staudt, Louis M, Reizis, Boris

“…Plasmacytoid dendritic cells (pDCs) rapidly produce type I interferon (IFN-I) in response to viruses and are essential for antiviral immune responses. Although…”
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Regulation of Immunoglobulin Light-Chain Recombination by the Transcription Factor IRF-4 and the Attenuation of Interleukin-7 Signaling by Johnson, Kristen, Hashimshony, Tamar, Sawai, Catherine M., Pongubala, Jagan M.R., Skok, Jane A., Aifantis, Iannis, Singh, Harinder

“…Productive rearrangement of the immunoglobulin heavy-chain locus triggers a major developmental checkpoint that promotes limited clonal expansion of pre-B…”
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Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease by Sawai, Catherine M, Serpas, Lee, Neto, Antonio Galvao, Jang, Geunhyo, Rashidfarrokhi, Ali, Kolbeck, Roland, Sanjuan, Miguel A, Reizis, Boris, Sisirak, Vanja

“…Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by an aberrant immune response to microbial components of the gastrointestinal…”
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Kinetics of adult hematopoietic stem cell differentiation in vivo by Upadhaya, Samik, Sawai, Catherine M, Papalexi, Efthymia, Rashidfarrokhi, Ali, Jang, Geunhyo, Chattopadhyay, Pratip, Satija, Rahul, Reizis, Boris

“…Adult hematopoiesis has been studied in terms of progenitor differentiation potentials, whereas its kinetics in vivo is poorly understood. We combined…”
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Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells by Casanova-Acebes, María, Dalla, Erica, Leader, Andrew M., LeBerichel, Jessica, Nikolic, Jovan, Morales, Blanca M., Brown, Markus, Chang, Christie, Troncoso, Leanna, Chen, Steven T., Sastre-Perona, Ana, Park, Matthew D., Tabachnikova, Alexandra, Dhainaut, Maxime, Hamon, Pauline, Maier, Barbara, Sawai, Catherine M., Agulló-Pascual, Esperanza, Schober, Markus, Brown, Brian D., Reizis, Boris, Marron, Thomas, Kenigsberg, Ephraim, Moussion, Christine, Benaroch, Philippe, Aguirre-Ghiso, Julio A., Merad, Miriam

“…Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and response to immunotherapy, which makes them an important target…”
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In-vivo differentiation of adult hematopoietic stem cells from a single-cell point of view by Nazaraliyev, Amal, Richard, Elodie, Sawai, Catherine M.

“…PURPOSE OF REVIEWAlthough hematopoietic stem cell (HSC) function has long been studied by transplantation assays, this does not reflect what HSCs actually do…”
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New genetic tools for the in vivo study of hematopoietic stem cell function by Upadhaya, Samik, Reizis, Boris, Sawai, Catherine M.

“…•Genetic reporter systems enable prospective identification of bona fide hematopoietic stem cells (HSCs).•Most adult HSCs make a major contribution to…”
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Stem cell decoupling underlies impaired lymphoid development during aging by Jang, Geunhyo, Contreras Castillo, Stephania, Esteva, Eduardo, Upadhaya, Samik, Feng, Jue, Adams, Nicholas M, Richard, Elodie, Awatramani, Rajeshwar, Sawai, Catherine M, Reizis, Boris

“…Mammalian aging is associated with multiple defects of hematopoiesis, most prominently with the impaired development of T and B lymphocytes. This defect is…”
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Therapeutic Targeting of the Cyclin D3:CDK4/6 Complex in T Cell Leukemia by Sawai, Catherine M., Freund, Jacquelyn, Oh, Philmo, Ndiaye-Lobry, Delphine, Bretz, Jamieson C., Strikoudis, Alexandros, Genesca, Lali, Trimarchi, Thomas, Kelliher, Michelle A., Clark, Marcus, Soulier, Jean, Chen-Kiang, Selina, Aifantis, Iannis

“…D-type cyclins form complexes with cyclin-dependent kinases (CDK4/6) and promote cell cycle progression. Although cyclin D functions appear largely tissue…”
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Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties by Ural, Basak B, Yeung, Stephen T, Damani-Yokota, Payal, Devlin, Joseph C, de Vries, Maren, Vera-Licona, Paola, Samji, Tasleem, Sawai, Catherine M, Jang, Geunhyo, Perez, Oriana A, Pham, Quynh, Maher, Leigh, Loke, P'ng, Dittmann, Meike, Reizis, Boris, Khanna, Kamal M

“…Tissue-resident macrophages are a diverse population of cells that perform specialized functions including sustaining tissue homeostasis and tissue…”
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Reuniting philosophy and science to advance cancer research by Pradeu, Thomas, Daignan‐Fornier, Bertrand, Ewald, Andrew, Germain, Pierre‐Luc, Okasha, Samir, Plutynski, Anya, Benzekry, Sébastien, Bertolaso, Marta, Bissell, Mina, Brown, Joel S., Chin‐Yee, Benjamin, Chin‐Yee, Ian, Clevers, Hans, Cognet, Laurent, Darrason, Marie, Farge, Emmanuel, Feunteun, Jean, Galon, Jérôme, Giroux, Elodie, Green, Sara, Gross, Fridolin, Jaulin, Fanny, Knight, Rob, Laconi, Ezio, Larmonier, Nicolas, Maley, Carlo, Mantovani, Alberto, Moreau, Violaine, Nassoy, Pierre, Rondeau, Elena, Santamaria, David, Sawai, Catherine M., Seluanov, Andrei, Sepich‐Poore, Gregory D., Sisirak, Vanja, Solary, Eric, Yvonnet, Sarah, Laplane, Lucie

“…ABSTRACT Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is…”
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A unique function for cyclin D3 in early B cell development by Clark, Marcus R, Aifantis, Iannis, Cooper, A Byron, Sawai, Catherine M, Sicinska, Ewa, Powers, Sarah E, Sicinski, Piotr

“…During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to…”
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Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells by Casanova-Acebes, María, Dalla, Erica, Leader, Andrew, Leberichel, Jessica, Nikolic, Jovan, Morales, Blanca, Brown, Markus, Chang, Christie, Troncoso, Leanna, Chen, Steven, Sastre-Perona, Ana, Park, Matthew, Tabachnikova, Alexandra, Dhainaut, Maxime, Hamon, Pauline, Maier, Barbara, Sawai, Catherine, Agulló-Pascual, Esperanza, Schober, Markus, Brown, Brian, Reizis, Boris, Marron, Thomas, Kenigsberg, Ephraim, Moussion, Christine, Benaroch, Philippe, Aguirre-Ghiso, Julio, Merad, Miriam

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Article: Regulation of Immunoglobulin Light-Chain Recombination by the Transcription Factor IRF-4 and the Attenuation of Interleukin-7 Signaling by Johnson, Kristen, Hashimshony, Tamar, Sawai, Catherine M, Pongubala, Jagan M R, Skok, Jane A, Aifantis, Iannis, Singh, Harinder

“…Productive rearrangement of the immunoglobulin heavy-chain locus triggers a major developmental checkpoint that promotes limited clonal expansion of pre-B…”
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The role of D-type cyclins in regulation of early lymphocyte development by Sawai, Catherine M

“…An important checkpoint during early B and T lymphopoiesis is the expression of the respective pre-B cell and pre-T cell receptor. Signaling initiated by the…”
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The role of D-type cyclins in regulation of early lymphocyte development by Sawai, Catherine M

“…An important checkpoint during early B and T lymphopoiesis is the expression of the respective pre-B cell and pre-T cell receptor. Signaling initiated by the…”
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