Search Results - "Sawada, Toyohiro"

Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets by Kojima, Hiroyuki, Yoshihara, Keiichi, Sawada, Toyohiro, Kondo, Hiromu, Sako, Kazuhiro

“…The purpose of this study was to evaluate the feasibility of using a counter polymer in polyethylene oxide (PEO)/polyethylene glycol (PEG) polymeric matrices…”
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The change of picrotoxin-induced epileptiform discharges to the beta oscillation by carbachol in rat hippocampal slices by Hashimoto, Ayumi, Sawada, Toyohiro, Natsume, Kiyohisa

“…The study aimed to determine whether and how the activation of the acetylcholine receptor affects epileptiform discharges in the CA3 region in a rat…”
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Influence of water soluble fillers in hydroxypropylmethylcellulose matrices on in vitro and in vivo drug release by Sako, Kazuhiro, Sawada, Toyohiro, Nakashima, Hiroshi, Yokohama, Shigeharu, Sonobe, Takashi

“…The purpose of this study was to investigate the effect of fillers in gel-forming matrix on in vivo drug release after oral dosing. A further purpose was to…”
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Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy by Sawada, Toyohiro, Kondo, Hiromu, Nakashima, Hiroshi, Sako, Kazuhiro, Hayashi, Masahiro

“…Compression-coated time-release tablets (CC tablets) containing nifedipine, dihydropyridine Ca channel blocker, in the core tablet were prepared by dry coating…”
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Scintigraphic evaluation of a novel colon-targeted delivery system (CODES) in healthy volunteers by Katsuma, Masataka, Watanabe, Shunsuke, Takemura, Shigeo, Sako, Kazuhiro, Sawada, Toyohiro, Masuda, Yoshinori, Nakamura, Katsutoshi, Fukui, Muneo, Connor, Alyson L, Wilding, Ian R

“…The purposes of this study are to investigate the gastrointestinal transit and release properties of a novel, colon-targeted delivery system (CODES)…”
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Timed-release formulation to avoid drug-drug interaction between diltiazem and midazolam by Sawada, Toyohiro, Sako, Kazuhiro, Yoshihara, Keiichi, Nakamura, Katsutoshi, Yokohama, Shigeharu, Hayashi, Masahiro

“…The purpose of this study was to investigate whether the use of a timed-release (TR) drug formulation can avoid unfavorable pharmacokinetic drug-drug…”
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The Use of Surrogate and Patient-Relevant Endpoints in Outcomes-Based Market Access Agreements: Current Debate by Toumi, Mondher, Jarosławski, Szymon, Sawada, Toyohiro, Kornfeld, Åsa

“…The high cost of novel treatments is the major driver of negative or restricted reimbursement decisions by healthcare payers in many countries. Costly drugs…”
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A new stressed test to predict the foreign matter formation of minodronic acid in solution by Nakamura, Katsutoshi, Yokohama, Shigeharu, Katsuma, Masataka, Sawada, Toyohiro, Sonobe, Takashi

“…A formulation containing 0.5 mg/ml minodronic acid, 40 mM citrate, pH 4.5, and sodium chloride, stored in regular flint glass ampoules, was stable without…”
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Relationship between gelation rate of controlled-release acetaminophen tablets containing polyethylene oxide and colonic drug release in dogs by SAKO, K, NAKASHIMA, H, SAWADA, T, FUKUI, M

“…We hypothesized that sufficient gelation of orally administered hydrophilic matrix tablets before they reach the colon could, as a result of continuous erosion…”
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Paracellular channel characterized by non-electrolyte permeation through the colonic membrane of the rat by Sawada, T, Tomita, M, Hayashi, M, Awazu, S

“…The mucosa-to-serosa permeability of non-electrolytes through the stripped colonic rat mucosa was examined in a Ussing-type chamber. The permeation clearances…”
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Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate by SAWADA, T, OGAWA, T, TOMITA, M, HAYASHI, M, AWAZU, S

“…The enhancing effects of 0.25% sodium caprate (C10) and sodium caprylate (C8) on the paracellular permeation of seven water-soluble nonelectrolytes (inulin,…”
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