Search Results - "Saw, Nay L."

Maturation and circuit integration of transplanted human cortical organoids by Revah, Omer, Gore, Felicity, Kelley, Kevin W., Andersen, Jimena, Sakai, Noriaki, Chen, Xiaoyu, Li, Min-Yin, Birey, Fikri, Yang, Xiao, Saw, Nay L., Baker, Samuel W., Amin, Neal D., Kulkarni, Shravanti, Mudipalli, Rachana, Cui, Bianxiao, Nishino, Seiji, Grant, Gerald A., Knowles, Juliet K., Shamloo, Mehrdad, Huguenard, John R., Deisseroth, Karl, Pașca, Sergiu P.

“…Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease 1 – 5 . However, organoids lack the…”
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Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease by Joshi, Amit U, Saw, Nay L, Shamloo, Mehrdad, Mochly-Rosen, Daria

“…Mitochondrial dynamics, involving a balance between fusion and fission, regulates mitochondrial quality and number. Increasing evidence suggests that…”
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Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis by Joshi, Amit U, Saw, Nay L, Vogel, Hannes, Cunnigham, Anna D, Shamloo, Mehrdad, Mochly‐Rosen, Daria

“…Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic lateral sclerosis (ALS), but whether these could be targeted…”
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Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome by Portmann, Thomas, Yang, Mu, Mao, Rong, Panagiotakos, Georgia, Ellegood, Jacob, Dolen, Gul, Bader, Patrick L., Grueter, Brad A., Goold, Carleton, Fisher, Elaine, Clifford, Katherine, Rengarajan, Pavitra, Kalikhman, David, Loureiro, Darren, Saw, Nay L., Zhengqui, Zhou, Miller, Michael A., Lerch, Jason P., Henkelman, R. Mark, Shamloo, Mehrdad, Malenka, Robert C., Crawley, Jacqueline N., Dolmetsch, Ricardo E.

“…A deletion on human chromosome 16p11.2 is associated with autism spectrum disorders. We deleted the syntenic region on mouse chromosome 7F3. MRI and…”
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Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids by Djurisic, Maja, Brott, Barbara K., Saw, Nay L., Shamloo, Mehrdad, Shatz, Carla J.

“…The threshold for Hebbian synaptic plasticity in the CNS is modulated by prior synaptic activity. At adult CA3-CA1 synapses, endocannabinoids play a role in…”
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Potential biomarkers to follow the progression and treatment response of Huntington's disease by Disatnik, Marie-Hélène, Joshi, Amit U, Saw, Nay L, Shamloo, Mehrdad, Leavitt, Blair R, Qi, Xin, Mochly-Rosen, Daria

“…Huntington's disease (HD) is a rare genetic disease caused by expanded polyglutamine repeats in the huntingtin protein resulting in selective neuronal loss…”
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Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior by Wawro, Adam M., Gajera, Chandresh R., Baker, Steven A., Leśniak, Robert K., Fischer, Curt R., Saw, Nay L., Shamloo, Mehrdad, Montine, Thomas J.

“…Imbalance of excitatory and inhibitory neurotransmission is implicated in a wide range of psychiatric and neurologic disorders. Here we tested the hypothesis…”
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Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in mice by Evans, Andrew K., Saw, Nay L., Woods, Claire E., Vidano, Laura M., Blumenfeld, Sarah E., Lam, Rachel K., Chu, Emily K., Reading, Chris, Shamloo, Mehrdad

“…•A high-fat diet impairs learning and memory in male mice and increases anxiety-like behavior across sexes and ages.•A high-fat diet exacerbates systemic…”
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Enantiomers of 4‐aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior by Wawro, Adam M., Gajera, Chandresh R., Baker, Steven A., Leśniak, Robert K., Montine, Kathleen S., Fischer, Curt R., Saw, Nay L., Shamloo, Mehrdad, Montine, Thomas J.

“…Imbalance in the metabolic pathway linking excitatory and inhibitory neurotransmission has been implicated in multiple psychiatric and neurologic disorders…”
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Schwann cell-secreted PGE 2 promotes sensory neuron excitability during development by Kantarci, Husniye, Elvira, Pablo D, Thottumkara, Arun P, O'Connell, Emma M, Iyer, Manasi, Donovan, Lauren J, Dugan, Micaela Quinn, Ambiel, Nicholas, Granados, Alejandro, Zeng, Hong, Saw, Nay L, Brosius Lutz, Amanda, Sloan, Steven A, Gray, Erin E, Tran, Khanh V, Vichare, Aditi, Yeh, Ashley K, Münch, Alexandra E, Huber, Max, Agrawal, Aditi, Morri, Maurizio, Zhong, Haining, Shamloo, Mehrdad, Anderson, Thomas Anthony, Tawfik, Vivianne L, Du Bois, J, Zuchero, J Bradley

“…Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development…”
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