Search Results - "Savvides, Christina"

Autoimmunity-associated T cell receptors recognize HLA-B27-bound peptides by Yang, Xinbo, Garner, Lee I., Zvyagin, Ivan V., Paley, Michael A., Komech, Ekaterina A., Jude, Kevin M., Zhao, Xiang, Fernandes, Ricardo A., Hassman, Lynn M., Paley, Grace L., Savvides, Christina S., Brackenridge, Simon, Quastel, Max N., Chudakov, Dmitriy M., Bowness, Paul, Yokoyama, Wayne M., McMichael, Andrew J., Gillespie, Geraldine M., Garcia, K. Christopher

“…Human leucocyte antigen B*27 (HLA-B*27) is strongly associated with inflammatory diseases of the spine and pelvis (for example, ankylosing spondylitis (AS))…”
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Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy by Yang, Xinbo, Nishimiya, Daisuke, Löchte, Sara, Jude, Kevin M., Borowska, Marta, Savvides, Christina S., Dougan, Michael, Su, Leon, Zhao, Xiang, Piehler, Jacob, Garcia, K. Christopher

“…Monoclonal antibodies (Abs) that recognize major histocompatability complex (MHC)-presented tumor antigens in a manner similar to T cell receptors (TCRs) have…”
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Immune receptor inhibition through enforced phosphatase recruitment by Fernandes, Ricardo A., Su, Leon, Nishiga, Yoko, Ren, Junming, Bhuiyan, Aladdin M., Cheng, Ning, Kuo, Calvin J., Picton, Lora K., Ohtsuki, Shozo, Majzner, Robbie G., Rietberg, Skyler P., Mackall, Crystal L., Yin, Qian, Ali, Lestat R., Yang, Xinbo, Savvides, Christina S., Sage, Julien, Dougan, Michael, Garcia, K. Christopher

“…Antibodies that antagonize extracellular receptor–ligand interactions are used as therapeutic agents for many diseases to inhibit signalling by cell-surface…”
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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy by Spangler, Jamie B, Trotta, Eleonora, Tomala, Jakub, Peck, Ariana, Young, Tracy A, Savvides, Christina S, Silveria, Stephanie, Votavova, Petra, Salafsky, Joshua, Pande, Vijay S, Kovar, Marek, Bluestone, Jeffrey A, Garcia, K Christopher

“…IL-2 has been used to treat diseases ranging from cancer to autoimmune disorders, but its concurrent immunostimulatory and immunosuppressive effects hinder…”
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A strategy for the selection of monovalent antibodies that span protein dimer interfaces by Spangler, Jamie B., Moraga, Ignacio, Jude, Kevin M., Savvides, Christina S., Garcia, K. Christopher

“…Ligand-induced dimerization is the predominant mechanism through which secreted proteins activate cell surface receptors to transmit essential biological…”
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Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo by Fernandes, Ricardo A, Li, Chaoran, Wang, Gang, Yang, Xinbo, Savvides, Christina S, Glassman, Caleb R, Dong, Shen, Luxenberg, Eric, Sibener, Leah V, Birnbaum, Michael E, Benoist, Christophe, Mathis, Diane, Garcia, K Christopher

“…T regulatory (Treg) cells play vital roles in modulating immunity and tissue homeostasis. Their actions depend on TCR recognition of peptide-MHC molecules; yet…”
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A Drosophila LexA Enhancer-Trap Resource for Developmental Biology and Neuroendocrine Research by Kockel, Lutz, Huq, Lutfi M, Ayyar, Anika, Herold, Emma, MacAlpine, Elle, Logan, Madeline, Savvides, Christina, Kim, Grace E S, Chen, Jiapei, Clark, Theresa, Duong, Trang, Fazel-Rezai, Vahid, Havey, Deanna, Han, Samuel, Jagadeesan, Ravi, Kim, Eun Soo Jackie, Lee, Diane, Lombardo, Kaelina, Piyale, Ida, Shi, Hansen, Stahr, Lydia, Tung, Dana, Tayvah, Uriel, Wang, Flora, Wang, Ja-Hon, Xiao, Sarah, Topper, Sydni M, Park, Sangbin, Rotondo, Cheryl, Rankin, Anne E, Chisholm, Townley W, Kim, Seung K

“…Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila…”
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