Search Results - "Savvateeva, Lyudmila V."
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Nanomedicine for increasing the oral bioavailability of cancer treatments
Published in Journal of nanobiotechnology (30-10-2021)“…Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient…”
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Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting
Published in Cancers (05-03-2020)“…Dendritic cells (DCs) have shown great potential as a component or target in the landscape of cancer immunotherapy. Different in vivo and ex vivo strategies of…”
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Intrinsically Connected: Therapeutically Targeting the Cathepsin Proteases and the Bcl-2 Family of Protein Substrates as Co-regulators of Apoptosis
Published in International journal of molecular sciences (28-04-2021)“…Taken with the growing importance of cathepsin-mediated substrate proteolysis in tumor biology and progression, the focus and emphasis placed on therapeutic…”
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Prospects of Developing Medicinal Therapeutic Strategies and Pharmaceutical Design for Effective Gluten Intolerance Treatment
Published in Current pharmaceutical design (01-01-2016)“…Gluten intolerance is an umbrella term for gluten-related disorders manifested in health decline as a result of the gluten ingestion. The spectrum of…”
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Structure determinants defining the specificity of papain-like cysteine proteases
Published in Computational and structural biotechnology journal (2022)“…[Display omitted] Papain-like cysteine proteases are widely expressed enzymes that mostly regulate protein turnover in the acidic conditions of lysosomes…”
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Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets
Published in Cells (Basel, Switzerland) (25-05-2024)“…Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various…”
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Cathepsin S Cleaves BAX as a Novel and Therapeutically Important Regulatory Mechanism for Apoptosis
Published in Pharmaceutics (05-03-2021)“…Certain lysosomal cathepsin proteins have come into focus as being good candidates for therapeutic targeting, based on them being over-expressed in a variety…”
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Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey
Published in International archives of allergy and immunology (01-01-2018)“…Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification…”
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Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence
Published in Journal of immunology research (01-01-2017)“…Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of dietary gluten from some cereals mainly in individuals carrying the HLA-DQ2…”
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Lost or Forgotten: The nuclear cathepsin protein isoforms in cancer
Published in Cancer letters (10-10-2019)“…While research into the role of cathepsins has been progressing at an exponential pace over the years, research into their respective isoform proteins has been…”
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Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity
Published in Biochimica et biophysica acta. General subjects (01-05-2024)“…Riboflavin (vitamin B2) is one of the most important water-soluble vitamins and a coenzyme involved in many biochemical processes. It has previously been shown…”
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Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy
Published in Drug design, development and therapy (01-01-2021)“…In cancer treatments, many natural and synthetic products have been examined; among them, protease inhibitors are promising candidates for anti-cancer agents…”
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Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis
Published in Cancers (22-11-2020)“…While viewed as the “guardian of the genome”, the importance of the tumor suppressor p53 protein has increasingly gained ever more recognition in modulating…”
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Novel applications of modification of thiol enzymes and redox-regulated proteins using S-methyl methanethiosulfonate (MMTS)
Published in Biochimica et biophysica acta. Proteins and proteomics (01-11-2019)“…S-Methyl methanethiosulfonate (MMTS) is used in experimental biochemistry for alkylating thiol groups of protein cysteines. Its applications include mainly…”
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Glutenase and collagenase activities of wheat cysteine protease Triticain-α: Feasibility for enzymatic therapy assays
Published in The international journal of biochemistry & cell biology (01-05-2015)“…Insufficient and/or improper protein degradation is associated with the development of various human pathologies. Enzymatic therapy with proteolytic enzymes…”
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Autoantibody against arrestin-1 as a potential biomarker of renal cell carcinoma
Published in Biochimie (01-02-2019)“…Renal cell carcinoma (RCC) is the second-most common uronephrological cancer. In the absence of specific symptoms, early diagnosis of RCC is challenging…”
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Rational Design of Recombinant Papain-Like Cysteine Protease: Optimal Domain Structure and Expression Conditions for Wheat-Derived Enzyme Triticain-α
Published in International journal of molecular sciences (29-06-2017)“…Triticain-α is a papain-like cysteine protease from wheat ( L.) that possesses activity towards toxic gluten-derived peptides, and was thus proposed as a novel…”
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The cancer-retina antigen recoverin as a potential biomarker for renal tumors
Published in Tumor biology (01-07-2016)“…The renal cell carcinoma is the ninth most common cancer with an increasing occurrence and mortality. Recoverin is the first retina-specific photoreceptor…”
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Questionnaire‐based survey to determine an at‐risk group for coeliac disease among school children in Moscow, Russia
Published in Journal of paediatrics and child health (01-10-2022)“…Aim Coeliac disease (CD) is a chronic digestive disorder which presents in diverse ways and is under‐diagnosed. The purpose of this study was to provide…”
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